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HDL and microRNAs

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HDL Metabolism and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1377))

Abstract

In previous chapters, we know that high-density lipoproteins (HDLs) could act at multiple cell lines and then trigger intracellular molecular pathway to prevent several metabolic diseases. Besides the classic genes regulating cholesterol efflux and reverse cholesterol transport (RCT), microRNAs (miRNAs) could also affect HDLs biogenesis, metabolism, and functions. This chapter summarizes the miRNAs, which regulate HDLs functions in table. In addition, HDLs are good vectors for miRNAs. They could carry miRNAs in circulation and take them into several cells such as macrophages and endothelial cells. Complete understanding of the miRNAs associated with HDL regulation would give us broader insights to prevent and treat metabolic diseases.

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Author information

Authors and Affiliations

  1. Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Key Laboratory of Molecular Cardiovascular Science, Ministry of Education, Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing, China

    Hongtu Cui

  2. School of Bioscience and Technology, Weifang Medical University, Weifang, Shandong, China

    Kaixuan Lv & Nana Yang

Authors
  1. Hongtu Cui
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  2. Kaixuan Lv
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  3. Nana Yang
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Corresponding author

Correspondence to Nana Yang .

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Editors and Affiliations

  1. Institute of Cardiovascular Sciences, Peking University, Beijing, China

    Lemin Zheng

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Cui, H., Lv, K., Yang, N. (2022). HDL and microRNAs. In: Zheng, L. (eds) HDL Metabolism and Diseases. Advances in Experimental Medicine and Biology, vol 1377. Springer, Singapore. https://doi.org/10.1007/978-981-19-1592-5_12

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