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An Integrated System for Unbiased Parkinson’s Disease Detection from Handwritten Drawings

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Advances in Intelligent Systems and Computing

Part of the book series: Smart Innovation, Systems and Technologies ((SIST,volume 268))

Abstract

Current Parkinson’s disease (PD) diagnosis relies on a series of hospital-based clinical examinations. To enable early PD detection at home, recognition from hand-written drawings is one way for automated PD detection system. However, existing methods have two main problems i.e., biasedness and lack of generalization in independent testing. The biasedness problem is due to two factors. The first factor is subject overlap between training and testing datasets caused by conventional validation methods. The second factor is imbalanced classes. In this paper, to avoid biasedness in the constructed models we utilize a balanced handwritten images. To avoid biasedness due to subject overlap, we use a more robust cross validation scheme i.e., leave one subject drawings out. In order to develop a decision support system to generalize to unseen data, we use several feature driven systems, and integrate F-score based feature selection model with those systems. Experimental results show that integration of F-score based model with Gaussian Naive Bayes model is a good candidate for PD detection based on hand-written drawings. It yields PD detection accuracy of 71.21% on main dataset and 63.04% on another dataset during independent testing.

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References

  1. Ali, L., Zhu, C., Zhou, M., Liu, Y.: Early diagnosis of Parkinson’s disease from multiple voice recordings by simultaneous sample and feature selection. Expert Syst. Appl. 138, 22–28 (2019)

    Article  Google Scholar 

  2. Van Den Eeden, S.K., Tanner, C.M., Bernstein, A.L., Fross, R.D., Leimpeter, A., Bloch, D.A., Nelson, L.M.: Incidence of Parkinson’s disease: variation by age, gender, and race/ethnicity. Am. J. Epidemiol. 157(11), 1015–1022 (2003)

    Article  Google Scholar 

  3. Pereira, C.R., Pereira, D.R., Silva, Francisco, A., Joo, P., Masieiro, S.A.T., Weber, C.H., Joo P.P.: A new computer vision-based approach to aid the diagnosis of Parkinson’s disease. Comput. Methods Progr. Biomed. 136, 79–88 (2016)

    Google Scholar 

  4. Drotr, P., Mekyska, J., Rektorov, I., Masarov, L., Smkal, Z., Faundez-Zanuy, M.: Evaluation of handwriting kinematics and pressure for differential diagnosis of Parkinson’s disease. Artif. Intell. Med. 67, 39–46 (2016)

    Google Scholar 

  5. Pereira, C.R., Pereira, D.R., Silva, F.A., Masieiro, J.P., Weber S.A.T., Hook, C., Papa, J.P.: A step towards the automated diagnosis of parkinson’s disease: Analyzing handwriting movements. In: IEEE 28th International Symposium on Computer-based Medical Systems, pp. 171–176 (2015)

    Google Scholar 

  6. Pereira, C.R., Pereira, D.R., Silva, F.A., Masieiro, J.P., Weber, S.A.T., Hook, C., Papa, J.P.: HandPD Dataset (2016). http://wwwp.fc.unesp.br/~papa/pub/datasets/Handpd/, Accessed: 15-Jan-2019

  7. Ali, L., Zhu, C., Golilarz, N.A., Javeed, A., Zhou, M., Liu, Y.: Reliable Parkinson’s disease detection by analyzing handwritten drawings: construction of an unbiased cascaded learning system based on feature selection and adaptive boosting model. IEEE Access 7, 116480–116489 (2019)

    Article  Google Scholar 

  8. Chen, Y.-W., Lin, C.-J.: Combining SVMs with various feature selection strategies. In: Feature Extraction, pp. 315–324 (2006)

    Google Scholar 

  9. Song, Q.J., Jiang, H.Y., Liu, J.: Feature selection based on FDA and F-score for multi-class classification. Expert Syst. Appl. 81, 22–27 (2017)

    Article  Google Scholar 

  10. Ali, L., Zhu, C., Zhang, Z., Liu, Y.: Automated detection of Parkinson’s disease based on multiple types of sustained phonations using linear discriminant analysis and genetically optimized neural network. IEEE J. Transl. Eng. Health Med. 7, 1–10 (2019)

    Article  Google Scholar 

  11. Kapanova, K.G., Dimov, I., Sellier, J.M.: A genetic approach to automatic neural network architecture optimization. Neural Comput. Appl. 29(5), 1481–1492 (2018)

    Article  Google Scholar 

  12. Tsanas, A., Little, M.A., McSharry, P.E., Spielman, J., Ramig, L.O.: Novel speech signal processing algorithms for high-accuracy classification of Parkinson’s disease. IEEE Trans. Biomed. Eng. 59(5), 1264–1271 (2012)

    Article  Google Scholar 

  13. Little, M.A., McSharry, P.E., Hunter, E.J., Spielman, J., Ramig, L.O., et al.: Suitability of dysphonia measurements for telemonitoring of Parkinson’s disease. IEEE Trans. Biomed. Eng. 56(4), 1015–1022 (2009)

    Article  Google Scholar 

  14. Zuo, W.-L., Wang, Z.-Y., Liu, T., Chen, H.-L.: Effective detection of Parkinson’s disease using an adaptive fuzzy k-nearest neighbor approach. Biomed. Signal Process. Control 8(4), 364–373 (2013)

    Article  Google Scholar 

  15. Kebin, W., Zhang, D., Guangming, L., Guo, Z.: Learning acoustic features to detect Parkinson’s disease. Neurocomputing 318, 102–108 (2018)

    Article  Google Scholar 

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Ali, L., Zhu, C., Zhao, H., Zhang, Z., Liu, Y. (2022). An Integrated System for Unbiased Parkinson’s Disease Detection from Handwritten Drawings. In: Zhang, JF., Chen, CM., Chu, SC., Kountchev, R. (eds) Advances in Intelligent Systems and Computing. Smart Innovation, Systems and Technologies, vol 268. Springer, Singapore. https://doi.org/10.1007/978-981-16-8048-9_1

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