Skip to main content
SpringerLink
Log in

A Review on Ethnomedicinal, Phytochemistry and Pharmacological Activities of Rumex hastatus D. Don

  • Chapter
  • First Online:
Edible Plants in Health and Diseases

  • 582 Accesses

Abstract

This book chapter summarizes selected scientific evidence on phytochemistry and pharmacological potential of Rumex hastatus. This herb is a bushy shrub and is an annual, biennial and perennial herb. The edible parts of the plant are young leaves and shoots (Padulosi 1999) belonging to the family Polygonaceae, and it is commonly known as khatimal. R. hastatus is commonly found in northern Pakistan, southwest of China and northeast Afghanistan. In India, it is widely distributed in western Himalayas, Himachal Pradesh, Jammu and Kashmir and Uttaranchal. It has been reported to possess a wide range of traditional medicinal uses including in asthma, cancer, rheumatism, diuretic, diarrhoea, dysentery, toothache, gum healing, jaundice, hepatitis, cough, fever, piles, carminative, purgative, fungal infection, lungs, bleeding and as a flavouring agent. Preliminary phytochemical screening showed that this plant is rich in various chemical constituents which are medicinally important such as flavonoids, anthraquinones, cardiac glycosides, alkaloids, terpenoids, tannins, saponins, phenolic compounds and coumarins. It has anti-nociceptive, antipyretic, anti-inflammatory, hepatic protective, anticholinesterase, antioxidant, antiradical, cytotoxic, anti-tumour, and angiogenic potential. The objective of the present current chapter is to collect all the relevant research articles which give information regarding traditional uses, phytochemistry and therapeutic potential of R. hastatus. R. hastatus has potential for curing various diseases and has been well studied for its phytochemical properties. However, further scientific studies are needed to explore mechanisms of actions, adverse effects of the extracts, toxicity and the therapeutic effect of major secondary metabolites.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

A. flavus :

Aspergillus flavus

A. fumigatus :

Aspergillus fumigatus

A. niger :

Aspergillus Niger

ABTS:

2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)

AChE:

Acetyl cholinesterase

AD:

Alzheimer’s disease

AIDS:

Autoimmuno deficiency disease

BChE:

Butyrylcholinesterase

ca.:

Circa (approx.)

CAM:

Chorioallantoic membrane assay

Cox-2:

Cyclooxygenase-2

DNA:

Deoxyribonucleic acid

DPPH:

Diphenyl-1-picrylhydrazyl

E. coli :

Escherichia coli

EtOH:

Ethanol

F. solani :

Fusarium solani

FID-MS:

Flame ionization detector with mass spectrometer

H2O2:

Hydrogen peroxide

HDL:

High-density lipoproteins

IUCN:

International Union for Conservation Research

LC50:

Lethal concentration

LDL:

Low-density lipoproteins

MeOH:

Methanol

NSAIDs:

Non-steroidal anti-inflammatory drugs

PFAF:

Plants for a future

PHCs:

Primary health Centre

R. hastatus :

Rumex hastatus

STD:

Sexually transmitted disease

TC:

Total cholesterol

TLC:

Thin layer chromatography

TNF:

Tumour necrosis factor

Tsp:

Teaspoon

UPLC-DAD:

Ultra-performance liquid chromatography method with diode array detection

References

  • Aarsland D et al (2008) Dementia in Parkinson’s disease. Curr Opin Neurol 21(6):676–682

    Article  PubMed  Google Scholar 

  • Abbasi, A. M., et al. (2010). “Herbal medicines used to cure various ailments by the inhabitants of Abbottabad district, north west Frontier Province, Pakistan”

    Google Scholar 

  • Abbasi, A. M., et al. (2011). Medicinal plant biodiversity of lesser Himalayas-Pakistan., Springer Science & Business Media

    Google Scholar 

  • Abbasi AM et al (2013) Botanical ethnoveterinary therapies in three districts of the lesser Himalayas of Pakistan. J Ethnobiol Ethnomed 9(1):84

    Article  PubMed  PubMed Central  Google Scholar 

  • Abdul M et al (2009) Biological evaluation of wild thyme (Thymus serpyllum). Pharm Biol 47(7):628–633

    Article  Google Scholar 

  • Adachi JA et al (2001) Enteroaggregative Escherichia coli as a major etiologic agent in traveler’s diarrhea in 3 regions of the world. Clin Infect Dis 32(12):1706–1709

    Article  CAS  PubMed  Google Scholar 

  • Afzal S et al (2014) Total phenolic content, in vitro radical scavenging and antimicrobial activities of whole plant Rumex hastatus. Sci Int 26(2):102–107

    Google Scholar 

  • Ahmad SS (2007) Medicinal wild plants from Lahore-Islamabad motorway (M-2). Pak J Bot 39(2):355

    Google Scholar 

  • Ahmad I, Aqil F (2007) In vitro efficacy of bioactive extracts of 15 medicinal plants against ESβL-producing multidrug-resistant enteric bacteria. Microbiol Res 162(3):264–275

    Article  PubMed  Google Scholar 

  • Ahmad S et al (2015) Antioxidant and anticholinesterase investigations of Rumex hastatus D. Don: potential effectiveness in oxidative stress and neurological disorders. Biol Res 48(1):20

    Article  PubMed  PubMed Central  Google Scholar 

  • Ahmad S et al (2016a) Antitumor and anti-angiogenic potentials of isolated crude saponins and various fractions of Rumex hastatus D. Don. Biol Res 49(1):18

    Article  PubMed  PubMed Central  Google Scholar 

  • Ahmad S et al (2016b) Evaluation of Rumex hastatus D. Don for cytotoxic potential against HeLa and NIH/3 T3 cell lines: chemical characterization of chloroform fraction and identification of bioactive compounds. BMC Complement Alternat Med 16(1):308

    Article  Google Scholar 

  • Ahmad S et al (2019) Nutritional and medicinal aspects of Rumex hastatus D. Don along with in vitro anti-diabetic activity. Int J Food Prop 22(1):1733–1748

    Article  CAS  Google Scholar 

  • Akhtar N, Mirza B (2018) Phytochemical analysis and comprehensive evaluation of antimicrobial and antioxidant properties of 61 medicinal plant species. Arab J Chem 11(8):1223–1235

    Article  CAS  Google Scholar 

  • Alberto J et al (2016) Some traditional medicinal plants of north region from Puebla, Mexico: uses and potential pharmacological activity of Rumex spp. Nat Prod Chem Res 4(223):2

    Google Scholar 

  • Ali H, Qaiser M (2009) The ethnobotany of Chitral valley, Pakistan with particular reference to medicinal plants. Pak J Bot 41(4):2009–2041

    Google Scholar 

  • Alwashli A et al (2012) Analgesic and anti-inflammatory activities of Boswellia elongata Balf Methanolic extracts, as endemic plants in Yemen. J Biol Active Prod Nat 2(2):90–98

    Google Scholar 

  • Andleeb S et al (2018) Biological activities and secondary metabolite screening of rumex hastatus extract through Fourier transform infrared and Raman spectroscopy. Infect Disord Drug Targets 18(2):164–176

    Article  CAS  PubMed  Google Scholar 

  • Anjen L et al (2003) 1a. Shrub, rarely a subshrub. Flora China 5:277–350

    Google Scholar 

  • Artis D, Spits H (2015) The biology of innate lymphoid cells. Nature 517(7534):293–301

    Article  CAS  Google Scholar 

  • Ashraf A et al (2015) Antioxidant, antimicrobial, antitumor, and cytotoxic activities of an important medicinal plant (Euphorbia royleana) from Pakistan. J Food Drug Anal 23(1):109–115

    Article  PubMed  Google Scholar 

  • Ashton C, J. (2012) Synthetic cannabinoids as drugs of abuse. Curr Drug Abuse Rev 5(2):158–168

    Article  CAS  PubMed  Google Scholar 

  • Atanasov AG et al (2015) Discovery and resupply of pharmacologically active plant-derived natural products: a review. Biotechnol Adv 33(8):1582–1614

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Avato P et al (2006) Antimicrobial activity of saponins from Medicago sp.: structure-activity relationship. Phytother Res 20(6):454–457

    Article  CAS  PubMed  Google Scholar 

  • Aziz MA et al (2018) Traditional uses of medicinal plants used by indigenous communities for veterinary practices at Bajaur agency, Pakistan. J Ethnobiol Ethnomed 14(1):11

    Article  PubMed  PubMed Central  Google Scholar 

  • Babu B et al (2001) Antioxidant and hepatoprotective effect of Acanthus ilicifolius. Fitoterapia 72(3):272–277

    Article  CAS  PubMed  Google Scholar 

  • Babulka P (2004) Les rumex, de l’ethnobotanique à la phytothérapie moderne (Rumex spp.). Phytothérapie 2(5):153–156

    Article  Google Scholar 

  • Baldioli M et al (1996) Antioxidant activity of tocopherols and phenolic compounds of virgin olive oil. J Am Oil Chem Soc 73(11):1589–1593

    Article  CAS  Google Scholar 

  • Bamiro F et al (1995) Comparative elemental contents (Cu, Ca, Zn, K, Mg, Ni, Fe and Cd) of seven various edible tubers in Nigeria. Pak J Sci Ind Res 38:316–318

    CAS  Google Scholar 

  • Bartha SG et al (2015) Ethnoveterinary practices of Covasna County, Transylvania, Romania. J Ethnobiol Ethnomed 11(1):35

    Article  PubMed  PubMed Central  Google Scholar 

  • Bektas N et al (2015) The role of muscarinic receptors in pain modulation. World J Pharmaceut Med Res 1(1):40–49

    Google Scholar 

  • Bhatia H et al (2018) Traditionally used wild edible plants of district Udhampur, J&K, India. J Ethnobiol Ethnomed 14(1):73

    Article  PubMed  PubMed Central  Google Scholar 

  • Bhatt V, Negi G (2006) Ethnomedicinal plant resources of Jaunsari tribe of Garhwal Himalaya, Uttaranchal. Indian J Tradit Knowl 5(3):331–335

    Google Scholar 

  • Bisht AS, Sharma DK (2014) Plants utilization by the communities of Bharsar and adjoining area of Pauri Garhwal District, Uttarakhand, India. Biodiversitas J Biol Diversity 15(1):94–100

    Google Scholar 

  • Borrego-Soto G et al (2015) Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer. Genet Mol Biol 38(4):420–432

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bouldin AS et al (1999) Pharmacy and herbal medicine in the US. Soc Sci Med 49(2):279–289

    Article  CAS  PubMed  Google Scholar 

  • Bourbonnas-Spear N et al (2005) Plant use by the Q’eqchi’Maya of Belize in ethnopsychiatry and neurological pathology. Econ Bot 59(4):326–336

    Article  Google Scholar 

  • Bown D (1995) The Royal Horticultural Society encyclopedia of herbs and their uses. Dorling Kindersley Limited

    Google Scholar 

  • Burkard G, Lehrl S (1991) Verhältnis von Demenzen vom Multiinfarkt-und vom Alzheimertyp in ärztlichen Praxen. Münch Med Wschr1 33(Suppl 1):38–43

    Google Scholar 

  • Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407(6801):249–257

    Article  CAS  PubMed  Google Scholar 

  • Castellsague J et al (2012) Safety of non-steroidal anti-inflammatory drugs (SOS) project individual NSAIDs and upper gastrointestinal complications: a systematic review and metaanalysis of observational studies (the SOS project). Drug Saf 35(12):1127

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Coats JR (1994) Risks from natural versus synthetic insecticides. Annu Rev. Entomol 39(1):489–515

    Article  CAS  PubMed  Google Scholar 

  • Coburn B (1984) Some native medicinal plants of the western Gurung. Kailash 1(1–2):55–88

    Google Scholar 

  • Cushnie TT, Lamb AJ (2005) Antimicrobial activity of flavonoids. Int J Antimicrob Agents 26(5):343–356

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Da Rocha AB et al (2001) Natural products in anticancer therapy. Curr Opin Pharmacol 1(4):364–369

    Article  PubMed  Google Scholar 

  • Das A et al (2002) A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba: anticholinesterase and cognitive enhancing activities. Pharmacol Biochem Behav 73(4):893–900

    Article  CAS  PubMed  Google Scholar 

  • Decker EA et al (2005) Measuring antioxidant effectiveness in food. J Agric Food Chem 53(10):4303–4310

    Article  CAS  PubMed  Google Scholar 

  • Deshpande S et al (2003) Antiulcer activity of Tephrosia purpurea in rats. Indian J Pharmacol 35(3):168–172

    Google Scholar 

  • Disler M et al (2014) Ethnoveterinary herbal remedies used by farmers in four north-eastern Swiss cantons (St. Gallen, Thurgau, Appenzell Innerrhoden and Appenzell Ausserrhoden). J Ethnobiol Ethnomed 10(1):32

    Article  PubMed  PubMed Central  Google Scholar 

  • Dutt HC et al (2015) Oral traditional knowledge on medicinal plants in jeopardy among Gaddi shepherds in hills of northwestern Himalaya, J&K, India. J Ethnopharmacol 168:337–348

    Article  PubMed  Google Scholar 

  • Fang J-Y et al (2001) Capsaicin and nonivamide as novel skin permeation enhancers for indomethacin. Eur J Pharm Sci 12(3):195–203

    Article  CAS  PubMed  Google Scholar 

  • Farnsworth NR (1988) Screening plants for new medicines. Biodiversity 15(3):81–99

    Google Scholar 

  • Fatima N et al (2009) Biological activities of Rumex dentatus L: evaluation of methanol and hexane extracts. Afr J Biotechnol 8(24):6945–6951

    Google Scholar 

  • Firestone GL, Sundar SN (2009) Anticancer activities of artemisinin and its bioactive derivatives. Expert Rev. Mol Med 11:e32

    Article  PubMed  Google Scholar 

  • Flescher E (2005) Jasmonates—a new family of anti-cancer agents. Anti-Cancer Drugs 16(9):911–916

    Article  CAS  PubMed  Google Scholar 

  • Folkman J (1992) The role of angiogenesis in tumor growth. Semin Cancer Biol 3(2):65–71

    CAS  PubMed  Google Scholar 

  • Ghane SG et al (2010) Indigofera glandulosa Wendl.(Barbada) a potential source of nutritious food: underutilized and neglected legume in India. Genet Resour Crop Evol 57(1):147–153

    Article  Google Scholar 

  • Ghosh S, Suryawanshi S (2001) Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats. Indian J Exp Biol 39(8):748–759

    CAS  PubMed  Google Scholar 

  • Gorsi MS, Miraj S (2002) Ethenomedicinal survey of plants of Khanabad village and its allied areas, District Gilgit. Asian J Plant Sci 1(5):604–615

    Article  Google Scholar 

  • Ha BG et al (2014) Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. Biofactors 40(4):436–447

    Article  CAS  PubMed  Google Scholar 

  • Hameed I, Dastagir G (2009) Nutritional analyses of Rumex hastatus D. Don, Rumex dentatus Linn and Rumex nepalensis Spreng. Afr J Biotechnol 8(17):4131–4133

    CAS  Google Scholar 

  • Hameed I et al (2008) Nutritional and elemental analyses of some selected medicinal plants of the family Polygonaceae. Pak J Bot 40(6):2493–2502

    CAS  Google Scholar 

  • Hameed I et al (2010) Anatomical studies of some medicinal plants of family Polygonaceae. Pak J Bot 42(5):2975–2983

    Google Scholar 

  • Haq F et al (2011) Traditional uses of medicinal plants of Nandiar Khuwarr catchment (District Battagram), Pakistan. Pak J Med Plant Res 5(1):39–48

    Google Scholar 

  • Haque N et al (2000) Evaluation of antitumor activity of some medicinal plants of Bangladesh by potato disk bioassay. Fitoterapia 71(5):547–552

    Article  CAS  PubMed  Google Scholar 

  • Heinrich M et al (2005) Spasmolytic and antidiarrhoeal properties of the Yucatec Mayan medicinal plant Casimiroa tetrameria. J Pharm Pharmacol 57(9):1081–1085

    Article  CAS  PubMed  Google Scholar 

  • Hernández-Pérez M, Rabanal RM (2002) Evaluation of the antiinflammatory and analgesic activity of Sideritis canariensis var. pannosa in mice. J Ethnopharmacol 81(1):43–47

    Article  PubMed  Google Scholar 

  • Hoge CW et al (1998) Trends in antibiotic resistance among diarrheal pathogens isolated in Thailand over 15 years. Clin Infect Dis 26(2):341–345

    Article  CAS  PubMed  Google Scholar 

  • Holman R, Turner R (1991) Oral agents and insulin in the treatment of NIDDM. Textbook of diabetes. Blackwell, Oxford, vol 9, p 467

    Google Scholar 

  • Hucho T, Levine JD (2007) Signaling pathways in sensitization: toward a nociceptor cell biology. Neuron 55(3):365–376

    Article  CAS  PubMed  Google Scholar 

  • Hussain F et al (2006) Ethnobotanical profile of plants of Shawar Valley, District Swat, Pakistan. Int J Biol Biotechnol 3(2):301–307

    Google Scholar 

  • Hussain A et al (2007) Cytotoxic and antitumor potential of Fagonia cretica L. Turk J Biol 31(1):19–24

    Google Scholar 

  • Hussain F et al (2010) Antibacterial, antifungal and insecticidal activities of some selected medicinal plants of Polygonaceae. Afr J Biotechnol 9(31):5032–5036

    Google Scholar 

  • Hussain SA et al (2015) Potential herbs and herbal nutraceuticals: food applications and their interactions with food components. Crit Rev Food Sci Nutr 55(1):94–122

    Article  CAS  PubMed  Google Scholar 

  • Inayatullah S et al (2012) Bioprospecting traditional Pakistani medicinal plants for potent antioxidants. Food Chem 132(1):222–229

    Article  CAS  PubMed  Google Scholar 

  • Ijaz F et al (2016) Investigation of traditional medicinal floral knowledge of Sarban Hills, Abbottabad, KP, Pakistan. J Ethnopharmacol 179:208–233

    Article  PubMed  Google Scholar 

  • Isailovic N et al (2015) Interleukin-17 and innate immunity in infections and chronic inflammation. J Autoimmun 60:1–11

    Article  CAS  PubMed  Google Scholar 

  • Islam M et al (2006) Weeds and medicinal plants of Shawar valley, District Swat. Pak J Weed Sci Res 12(1–2):83–88

    Google Scholar 

  • Islam M et al (2010) In vitro evaluation of Croton bonplandianum Baill. As potential antitumor properties using Agrobacterium tumefaciens. J Agric Technol 6(1):79–86

    Google Scholar 

  • Jan G et al (2011) Indigenous medicinal plants used by local people of Shahi, lower Dir (Khyber Pakhtunkhwa), southern Himalayan regions of Pakistan. Int J Biol Biotechnol 8(2):345–353

    Google Scholar 

  • Johns T, Eyzaguirre PB (2006) Linking biodiversity, diet and health in policy and practice. Proc Nutr Soc 65(2):182–189

    Article  PubMed  Google Scholar 

  • Jordan MA, Wilson L (2004) Microtubules as a target for anticancer drugs. Nat Rev. Cancer 4(4):253–265

    Article  CAS  PubMed  Google Scholar 

  • Julius D, Basbaum AI (2001) Molecular mechanisms of nociception. Nature 413(6852):203–210

    Article  CAS  PubMed  Google Scholar 

  • Kähkönen MP et al (1999) Antioxidant activity of plant extracts containing phenolic compounds. J Agric Food Chem 47(10):3954–3962

    Article  PubMed  Google Scholar 

  • Kamal Z et al (2015) Ex vivo antibacterial, phytotoxic and cytotoxic, potential in the crude natural phytoconstituents of Rumex hastatus D. Don. Pak J Bot 47(SI):293–299

    CAS  Google Scholar 

  • Kameswrarao B, et al (1997) Herbal medicine. In The management by indigenous resources, pp 375–377

    Google Scholar 

  • Kanowski S et al (1996) Proof of efficacy of the ginkgo biloba special extract EGb 761 in outpatients suffering from mild to moderate primary degenerative dementia of the Alzheimer type or multi-infarct dementia. Pharmacopsychiatry 29(02):47–56

    Article  CAS  PubMed  Google Scholar 

  • Khalifa A (2004) Herbs: nature’s pharmacy. Casablanca, Arab Cultural Center

    Google Scholar 

  • Khan M et al (2009) Medicinal plants of Sewa river catchment area in the Northwest Himalaya and its implication for conservation. Ethnobot Leafl 2009(9):5

    Google Scholar 

  • Kimura M, Yamada H (1984) Interaction in the antibacterial activity of flavonoids from Sophora japonica L. to Propionibacterium. Yakugaku Zasshi 104(4):340–346

    Article  CAS  PubMed  Google Scholar 

  • Kinghorn AD et al (2011) The relevance of higher plants in lead compound discovery programs. J Nat Prod 74(6):1539–1555

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Komiya T et al (1999) Phytol induces programmed cell death in human lymphoid leukemia molt 4B cells. Int J Mol Med 4(4):377–457

    CAS  PubMed  Google Scholar 

  • Krenn L, Paper D (2009) Inhibition of angiogenesis and inflammation by an extract of red clover (Trifolium pratense L.). Phytomedicine 16(12):1083–1088

    Article  CAS  PubMed  Google Scholar 

  • Krishnaiah D et al (2007) Phytochemical antioxidants for health and medicine a move towards nature. Biotechnol Mol Biol Rev 2(4):97–104

    Google Scholar 

  • Kuete V et al (2013) Cytotoxicity, mode of action and antibacterial activities of selected Saudi Arabian medicinal plants. BMC Complement Altern Med 13(1):354

    Article  PubMed  PubMed Central  Google Scholar 

  • Kumar GPS et al (2006) Anti-diabetic activity of fruits of Terminalia chebula on streptozotocin induced diabetic rats. J Health Sci 52(3):283–291

    Article  Google Scholar 

  • Kumar H et al (2012) The role of free radicals in the aging brain and Parkinson’s disease: convergence and parallelism. Int J Mol Sci 13(8):10478–10504

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kumari S et al (2013) An ethnobotanical survey of medicinal plants used by Gujjar Community of Trikuta Hills in Jammu and Kashmir, India. J Med Plant Res 7(28):2111–2121

    Article  Google Scholar 

  • LaPoint J et al (2011) Severe toxicity following synthetic cannabinoid ingestion. Clin Toxicol 49(8):760–764

    Article  CAS  Google Scholar 

  • Le Bars PL et al (1997) A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. JAMA 278(16):1327–1332

    Article  PubMed  Google Scholar 

  • Lewin GR et al (2004) A plethora of painful molecules. Curr Opin Neurobiol 14(4):443–449

    Article  CAS  PubMed  Google Scholar 

  • Liang HX et al (2010) Bioactive compounds from Rumex plants. Phytochem Lett 3(4):181–184

    Article  CAS  Google Scholar 

  • List P (2010) The plant list, Version

    Google Scholar 

  • List P (2013) The Plantlist working list of all plant species, version 1.1 September 2013, [cited 2015 Jan 26]

    Google Scholar 

  • Liu J-Y et al (2006) The protective effects of Hibiscus sabdariffa extract on CCl4-induced liver fibrosis in rats. Food Chem Toxicol 44(3):336–343

    Article  CAS  PubMed  Google Scholar 

  • Loizzo MR et al (2008) Natural products and their derivatives as cholinesterase inhibitors in the treatment of neurodegenerative disorders: an update. Curr Med Chem 15(12):1209–1228

    Article  CAS  PubMed  Google Scholar 

  • Magbagbeola J et al (2010) Neglected and underutilized species (NUS): a panacea for community focused development to poverty alleviation/poverty reduction in Nigeria. J Econ Int Finan 2(10):208–211

    Google Scholar 

  • Maiti A et al (2007) In vivo evaluation of antidiarrhoeal activity of the seed of Swietenia macrophylla king (Meliaceae). Trop J Pharm Res 6(2):711–716

    Article  Google Scholar 

  • Mal B (2007) Neglected and underutilized crop genetic resources for sustainable agriculture. Indian J Plant Genet Resour 20(1):1–14

    Google Scholar 

  • Manan Z et al (2007) Diversity of medicinal plants in Wari subdivision District Upper Dir, Pakistan. Pak J Plant Sci (Pakistan) 13(1):19–26

    Google Scholar 

  • Manandhar NP (1995) A survey of medicinal plants of Jajarkot District, Nepal. J Ethnopharmacol 48(1):1–6

    Article  CAS  PubMed  Google Scholar 

  • Manandhar NP (2002) Plants and people of Nepal. Timber Press, Portland

    Google Scholar 

  • Mani M et al (2010) Anti-diarrhoeal activity of methanolic extract of root bark of Ailanthus altissima Swingle (family: Simaroubaceae) on experimental animals. Int J Pharm Sci Res 1:197–202

    Google Scholar 

  • Mclaughlin JL et al (1998) The use of biological assays to evaluate botanicals. Drug Inf J 32(2):513–524

    Article  Google Scholar 

  • Mehendale HM (2005) Tissue repair: an important determinant of final outcome of toxicant-induced injury. Toxicol Pathol 33(1):41–51

    Article  CAS  PubMed  Google Scholar 

  • Mehendale S et al (2008) Fatty acids, antioxidants, and oxidative stress in pre-eclampsia. Int J Gynecol Obstet 100(3):234–238

    Article  CAS  Google Scholar 

  • Mellitus D (2005) Diagnosis and classification of diabetes mellitus. Diabetes Care 28(S37):S5–S10

    Google Scholar 

  • Mishra AP et al (2018) Bioactive compounds and health benefits of edible Rumex species-a review. Cell Mol Biol 64(8):27–34

    Article  Google Scholar 

  • MiuRA T et al (2002) Isoflavone aglycon produced by culture of soybean extracts with basidiomycetes and its anti-angiogenic activity. Biosci Biotechnol Biochem 66(12):2626–2631

    Article  CAS  PubMed  Google Scholar 

  • Mohamed AF et al (2015) Patient benefit-risk tradeoffs for radioactive iodine-refractory differentiated thyroid cancer treatments. J Thyroid Res 2015:438235

    Article  PubMed  PubMed Central  Google Scholar 

  • Mohammed A et al (2009) Preliminary anti-diarrhoeal activity of hydromethanolic extract of aerial part of Indigofera pulchra in rodents. Asian J Med Sci 1(2):22–25

    Google Scholar 

  • Montgomery SL, Bowers WJ (2012) Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system. J Neuroimmune Pharmacol 7(1):42–59

    Article  PubMed  Google Scholar 

  • Mukherjee PK et al (2007) In vitro acetylcholinesterase inhibitory activity of the essential oil from Acorus calamus and its main constituents. Planta Med 73(3):283

    Article  CAS  PubMed  Google Scholar 

  • Murad W et al (2011) Indigenous knowledge and folk use of medicinal plants by the tribal communities of Hazar Nao Forest, Malakand District, North Pakistan. J Med Plant Res 5(7):1072–1086

    Google Scholar 

  • Nadkarni K, Nadkarni AK (1976) Indian Materia Medica, vol 1. Popular Prakashan Pvt. Ltd., Bombay, p 799

    Google Scholar 

  • Navajas-Pérez R et al (2005) The evolution of reproductive systems and sex-determining mechanisms within Rumex (Polygonaceae) inferred from nuclear and chloroplastidial sequence data. Mol Biol Evol 22(9):1929–1939

    Article  PubMed  Google Scholar 

  • Nickel FT et al (2012) Mechanisms of neuropathic pain. Eur Neuropsychopharmacol 22(2):81–91

    Article  CAS  PubMed  Google Scholar 

  • Ofman JJ et al (2002) A metaanalysis of severe upper gastrointestinal complications of nonsteroidal antiinflammatory drugs. J Rheumatol 29(4):804–812

    CAS  PubMed  Google Scholar 

  • Ogram A et al (1987) The extraction and purification of microbial DNA from sediments. J Microbiol Methods 7(2–3):57–66

    Article  CAS  Google Scholar 

  • Oke J, Hamburger M (2002) Screening of some Nigerian medicinal plants for antioxidant activity using 2, 2, diphenyl-picrylhydrazyl radical. Afr J Biomed Res 5(1–2):77–79

    Google Scholar 

  • Öztürk M et al (2011) In vitro antioxidant, anticholinesterase and antimicrobial activity studies on three Agaricus species with fatty acid compositions and iron contents: a comparative study on the three most edible mushrooms. Food Chem Toxicol 49(6):1353–1360

    Article  PubMed  Google Scholar 

  • Padulosi S, Eyzaquirre P, Hodgkin T (1999) Challenges and strategies in promoting conservation and use of neglected and underutilized crop species. In Perspectives on new crops and new uses, pp 140–145

    Google Scholar 

  • Pande P et al (2007) Ethno veterinary plants of Uttaranchal—a review. IJTK 6(3):444–458

    Google Scholar 

  • Pastor C et al (1995) Liver injury during sepsis. J Crit Care 10(4):183–197

    Article  CAS  PubMed  Google Scholar 

  • Paul P, Chowdhury M (2019) Diversity of members of Polygonaceae from West Bengal, India. Plant Arch 19(2):157–164

    Google Scholar 

  • Pedraza-Alva G et al (2015) Negative regulation of the inflammasome: keeping inflammation under control. Immunol Rev 265(1):231–257

    Article  CAS  PubMed  Google Scholar 

  • Pohle P (1990) Useful plants of Manang district: a contribution to the ethnobotany of the Nepal Himalaya. Nepal Research Centre, Nepal

    Google Scholar 

  • Pope LE et al (2001) Treatment of hyperproliferative skin disorders with C18 to C20 aliphatic alcohols. Google Patents

    Google Scholar 

  • Qaiser M (2001) Polygonaceae in Flora of Pakistan. No. 205, Karachi

    Google Scholar 

  • Rahman IU et al (2016) A novel survey of the ethno medicinal knowledge of dental problems in Manoor Valley (Northern Himalaya), Pakistan. J Ethnopharmacol 194:877–894

    Article  PubMed  Google Scholar 

  • Rao BK et al (2001) Antihyperglycemic activity of Momordica cymbalaria in alloxan diabetic rats. J Ethnopharmacol 78(1):67–71

    Article  CAS  PubMed  Google Scholar 

  • Ruberto G, Baratta MT (2000) Antioxidant activity of selected essential oil components in two lipid model systems. Food Chem 69(2):167–174

    Article  CAS  Google Scholar 

  • Ruch RJ et al (1989) Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea. Carcinogenesis 10(6):1003–1008

    Article  CAS  PubMed  Google Scholar 

  • Sahreen S et al (2010) Evaluation of antioxidant activities of various solvent extracts of Carissa opaca fruits. Food Chem 122(4):1205–1211

    Article  CAS  Google Scholar 

  • Sahreen S et al (2011) Phenolic compounds and antioxidant activities of Rumex hastatus D. Don. Leaves. J Med Plant Res 5(13):2755–2765

    CAS  Google Scholar 

  • Sahreen S et al (2013) Ameliorating effect of various fractions of Rumex hastatus roots against hepato-and testicular toxicity caused by CCl 4. Oxid Med Cell Longev 2013:325406

    Article  PubMed  PubMed Central  Google Scholar 

  • Sahreen S et al (2014) Comprehensive assessment of phenolics and antiradical potential of Rumex hastatus D. Don. roots. BMC Complement Altern Med 14(1):47

    Article  PubMed  PubMed Central  Google Scholar 

  • Sahreen S et al (2015) Evaluation of phytochemical content, antimicrobial, cytotoxic and antitumor activities of extract from Rumex hastatus D. Don roots. BMC Complement Altern Med 15(1):211

    Article  PubMed  PubMed Central  Google Scholar 

  • Sahreen S et al (2017) Evaluation of Rumex hastatus leaves against hepatic fibrosis: a rat model. BMC Complement Altern Med 17(1):435

    Article  PubMed  PubMed Central  Google Scholar 

  • Salvador JA et al (2013) Anticancer steroids: linking natural and semi-synthetic compounds. Nat Prod Rep 30(2):324–374

    Article  CAS  PubMed  Google Scholar 

  • Schlachterman A et al (2008) Combined resveratrol, quercetin, and catechin treatment reduces breast tumor growth in a nude mouse model. Transl Oncol 1(1):19

    Article  PubMed  PubMed Central  Google Scholar 

  • Scholz J, Woolf CJ (2002) Can we conquer pain? Nat Neurosci 5(11):1062–1067

    Article  CAS  PubMed  Google Scholar 

  • Seidemann J (2005) World spice plants: economic usage, botany, taxonomy. Springer Science & Business Media

    Google Scholar 

  • Sen S et al (2010) Analgesic and anti-inflammatory herbs: a potential source of modern medicine. Int J Pharm Sci Res 1(11):32

    Google Scholar 

  • Sengupta A, Ghosh M (2012) Comparison of native and capric acid-enriched mustard oil effects on oxidative stress and antioxidant protection in rats. Br J Nutr 107(6):845–849

    Article  CAS  PubMed  Google Scholar 

  • Shafiq N et al (2017) Chemical and biological analysis of the extract from the plant Rumex hastatus for its secondary metabolites. Res J Life Sci Bioinf Pharm Chem Sci 3:40–44

    Google Scholar 

  • Shah S et al (2015) Phytochemicals, in vitro antioxidant, total phenolic contents and phytotoxic activity of Cornus macrophylla Wall bark collected from the North-West of Pakistan. Pak J Pharm Sci 28(1):23–28

    CAS  PubMed  Google Scholar 

  • Shaheen H et al (2012) Indigenous plant resources and their utilization practices in village populations of Kashmir Himalayas. Pak J Bot 44(2):739–745

    Google Scholar 

  • Shahidi F et al (1992) Phenolic antioxidants. Crit Rev Food Sci Nutr 32(1):67–103

    Article  CAS  PubMed  Google Scholar 

  • Shakuntala BP et al (2011) Evaluation of antidiarrhoeal activity of extract from roots of Rumex hastatus (family: Polygonaceae) on experimental animals. J Appl Pharm Sci 1(6):182–185

    Google Scholar 

  • Shaphiullah M et al (2003) Antidiarrheal activity of the methanol extract of Ludwigia hyssopifolia Linn. Pak J Pharm Sci 16(1):7–11

    PubMed  Google Scholar 

  • Sharma R et al (2018) Comprehensive metabolomics study of traditionally important Rumex species found in Western Himalayan region. Nat Prod Commun 13(2):1934578X1801300219

    CAS  Google Scholar 

  • Shedayi AA et al (2014) Traditional medicinal uses of plants in Gilgit-Baltistan, Pakistan. J Med Plant Res 8(30):992–1004

    Article  Google Scholar 

  • Sher H et al (2015) Indigenous knowledge of folk medicines among tribal minorities in Khyber Pakhtunkhwa, northwestern Pakistan. J Ethnopharmacol 166:157–167

    Article  PubMed  Google Scholar 

  • Shinwari ZK, Gilani SS (2003) Sustainable harvest of medicinal plants at Bulashbar Nullah, Astore (northern Pakistan). J Ethnopharmacol 84(2–3):289–298

    Article  PubMed  Google Scholar 

  • Singh P, Attri BL (2014) Survey on traditional uses of medicinal plants of Bageshwar Valley (Kumaun Himalaya) of Uttarakhand, India. Int J Conserv Sci 5(2):223–234

    Google Scholar 

  • Singh KJ, Thakur AK (2014) Medicinal plants of the Shimla hills, Himachal Pradesh: a survey. Int J Herb Med 2(2):118–127

    Google Scholar 

  • Singh MP et al (2002) Plant biodiversity and taxonomy. Daya Books

    Google Scholar 

  • Singh S et al (2013a) Antinociceptive, antiinflammatory and antipyretic activities of Rumex hastatus D. don stem and roots. Der Pharmacia Sinica 4(3):95–102

    Google Scholar 

  • Singh S et al (2013b) Pharmacognostical standardization of the roots of Rumex hastatus D. Don Asian J Pharm Clin Res 6:126–128

    Google Scholar 

  • Singh S et al (2013c) A review on Cassia species: pharmacological, traditional and medicinal aspects in various countries. Am J Phytomedicine and Clin Ther 1(3):291–312

    Google Scholar 

  • Singh J et al (2014) Wild vegetable plants used by tribal people of Kinnaur district, Himachal Pradesh, India. Int J Usuf Mngt 15(2):47–56

    Google Scholar 

  • Sinha RK, Sinha S (2001) Ethnobiology: role of indigenous and ethnic societies in biodiversity conservation, human health protection and sustainable development. Surabhi Publications

    Google Scholar 

  • Small GW et al (1997) Diagnosis and treatment of Alzheimer disease and related disorders: consensus statement of the American Association for Geriatric Psychiatry, the Alzheimer’s Association, and the American Geriatrics Society. JAMA 278(16):1363–1371

    Article  CAS  PubMed  Google Scholar 

  • Srivastava JP et al (1996) Medicinal plants: an expanding role in development. The World Bank

    Google Scholar 

  • Stamatis H et al (1999) Studies on the enzymatic synthesis of lipophilic derivatives of natural antioxidants. J Am Oil Chem Soc 76(12):1505

    Article  CAS  Google Scholar 

  • Steinberg GM et al (1975) Hydrophobic binding site in acetylcholinesterase. J Med Chem 18(11):1056–1061

    Article  CAS  Google Scholar 

  • Stevenson D, Hurst R (2007) Polyphenolic phytochemicals—just antioxidants or much more? Cell Mol Life Sci 64(22):2900–2916

    Article  CAS  PubMed  Google Scholar 

  • Sultana S et al (2017) Chemical constituents from the aerial parts of Rumex hastatus D. Don. J Pharm Biol Sci 5(5):179–187

    Google Scholar 

  • Tariq A et al (2014) Ethnoveterinary study of medicinal plants in a tribal society of Sulaiman range. Sci World J 2014:10

    Article  Google Scholar 

  • Taylor R et al (1996) Antiviral activities of medicinal plants of southern Nepal. J Ethnopharmacol 53(2):105–110

    Article  Google Scholar 

  • Uddin K et al (2014) Taxonomy and traditional medicine practices of Polygonaceae (smartweed) family at Rajshahi, Bangladesh. Int J Adv Res 2(11):459–469

    Google Scholar 

  • Uniyal SK et al (2006) Traditional use of medicinal plants among the tribal communities of Chhota Bhangal, Western Himalaya. J Ethnobiol Ethnomed 2(1):14

    Article  PubMed  PubMed Central  Google Scholar 

  • Ullah A, Rashid A (2007) Valley, Hindukush range, Pakistan. Pak J Weed Sci Res 13(1–2):27–32

    Google Scholar 

  • Ullah R et al (2010) Traditional uses of medicinal plants in Darra Adam Khel NWFP Pakistan. J Med Plant Res 4(17):1815–1821

    Google Scholar 

  • Ullah A et al (2014) Medicinal plants used in the isolated region of Bumburet, Kalash Valley, District Chitral, Pakistan. Pak J Weed Sci Res 20(3):359–373

    Google Scholar 

  • Uniyal B, Shiva V (2005) Traditional knowledge on medicinal plants among rural women of the Garhwal Himalaya, Uttaranchal. Indian J Tradit Knowl 4(3):259–266

    Google Scholar 

  • Valko M et al (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160(1):1–40

    Article  CAS  PubMed  Google Scholar 

  • Vasas A et al (2015) The genus Rumex: review of traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 175:198–228

    Article  CAS  PubMed  Google Scholar 

  • Vats V et al (2004) Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats. J Ethnopharmacol 90(1):155–160

    Article  CAS  PubMed  Google Scholar 

  • Verma KK (2019) Protective effect of Rumex hastatus leaves extract against hepatic and cognitive decline in animal models of liver cirrhosis

    Google Scholar 

  • Vermani K, Garg S (2002) Herbal medicines for sexually transmitted diseases and AIDS. J Ethnopharmacol 80(1):49–66

    Article  PubMed  Google Scholar 

  • Vignali DA, Kuchroo VK (2012) IL-12 family cytokines: immunological playmakers. Nat Immunol 13(8):722

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vogl CR et al (2016) Local knowledge held by farmers in eastern Tyrol (Austria) about the use of plants to maintain and improve animal health and welfare. J Ethnobiol Ethnomed 12(1):40

    Article  PubMed  PubMed Central  Google Scholar 

  • Wallis, T. E. (1997). Delhi, CBS publishers

    Google Scholar 

  • Wang S et al (2004) Angiogenesis and anti-angiogenesis activity of Chinese medicinal herbal extracts. Life Sci 74(20):2467–2478

    Article  CAS  PubMed  Google Scholar 

  • Xi M et al (2008) Antioxidant and antiglycation properties of total saponins extracted from traditional Chinese medicine used to treat diabetes mellitus. Phytother Res 22(2):228–237

    Article  CAS  PubMed  Google Scholar 

  • Yaniv Z, Bachrach U (2005) Handbook of medicinal plants. CRC Press, Boca Raton

    Book  Google Scholar 

  • Yi B-H, Kim D-H (1982) Antioxidant activity of maltol, kojic acid, levulinic acid, furfural, 5-hydroxymethyl furfural, and pyrazine. Korean J Food Sci Technol 14(3):265–270

    CAS  Google Scholar 

  • Yu W et al (2009) Anticancer actions of natural and synthetic vitamin E forms: RRR-α-tocopherol blocks the anticancer actions of γ-tocopherol. Mol Nutr Food Res 53(12):1573–1581

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zabta K et al (2003) Medicinal plants and other useful plants of District Swat, Pakistan. Al Aziz Press, Peshawar, p 79

    Google Scholar 

  • Zelová H, Hošek J (2013) TNF-α signalling and inflammation: interactions between old acquaintances. Inflamm Res 62(7):641–651

    Article  PubMed  Google Scholar 

  • Zendehdel, M., et al. (2011). “Evaluation of pharmacological mechanisms of antinociceptive effect of Teucrium polium on visceral pain in mice”

    Google Scholar 

  • Zhang LS et al (2009) Hastatusides a and B: two new phenolic glucosides from Rumex hastatus. Helv Chim Acta 92(4):774–778

    Article  CAS  Google Scholar 

  • Zhang Y et al (2014) Diversity of wetland plants used traditionally in China: a literature review. J Ethnobiol Ethnomed 10(1):72

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

Author Contributions: All authors had equally contributed to writing of this book chapter.

Conflict of Interest: There is no competing interests.

Author information

Authors and Affiliations

  1. Pharmacognosy and Phytochemistry, School of Applied Sciences and Technology, Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir, India

    Iflah Hassan,  Insha Mushtaq, Weekar Younus Raja & Zulfiqar Ali Bhat

Authors
  1. Iflah Hassan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Insha Mushtaq
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Weekar Younus Raja
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zulfiqar Ali Bhat
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Pharmaceutical Sciences School of Applied Science & Technology, University of Kashmir, Srinagar, Jammu and Kashmir, India

    Mubashir Hussain Masoodi

  2. Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

    Muneeb U Rehman

Rights and permissions

Reprints and permissions

Copyright information

© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Hassan, I., Insha Mushtaq, Raja, W.Y., Bhat, Z.A. (2022). A Review on Ethnomedicinal, Phytochemistry and Pharmacological Activities of Rumex hastatus D. Don. In: Masoodi, M.H., Rehman, M.U. (eds) Edible Plants in Health and Diseases . Springer, Singapore. https://doi.org/10.1007/978-981-16-4959-2_6

Download citation

Publish with us

Policies and ethics

Search

Navigation