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Marine Collagen: Promising Biomaterial in Delivery of Therapeutics for Cancer Therapy

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Marine Biomaterials

Abstract

Collagens are high-molecular-weight complex dominant proteins present in all living organisms. Various organisms have been exploited to extract collagen of different types, through different extraction methodologies. Marine organisms are excellent alternative sources of huge amounts of collagen. Marine vertebrates, including whale, fishes, seals, and sea otters, are significant sources of marine collagen. Moreover, marine invertebrates such as jellyfish, marine sponges, cuttlefish, and octopus are also considerable sources of marine collagen with significant clinical values. Marine collagen is a promising tool for wide-ranging clinical applications including as a drug delivery system for cancer and other diseases.

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References

  • Acerbi I et al (2015) Human breast cancer invasion and aggression correlates with ECM stiffening and immune cell infiltration. Integr Biol 7(10):1120–1134

    Article  CAS  Google Scholar 

  • Addad S et al (2011) Isolation, characterization and biological evaluation of jellyfish collagen for use in biomedical applications. Mar Drugs 9(6):967–983

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Afik R et al (2016) Tumor macrophages are pivotal constructors of tumor collagenous matrix. J Exp Med 213(11):2315–2331

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Alves AL et al (2017) Cosmetic potential of marine fish skin collagen. Cosmetics 4(4):39

    Article  CAS  Google Scholar 

  • Amenta PS et al (2005) Proteoglycan-collagen XV in human tissues is seen linking banded collagen fibers subjacent to the basement membrane. J Histochem Cytochem 53(2):165–176

    Article  CAS  PubMed  Google Scholar 

  • Ansorge HL et al (2009) Type XIV collagen regulates fibrillogenesis: premature collagen fibril growth and tissue dysfunction in null mice. J Biol Chem 284(13):8427–8438

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Aouacheria A et al (2006) Insights into early extracellular matrix evolution: spongin short chain collagen-related proteins are homologous to basement membrane type IV collagens and form a novel family widely distributed in invertebrates. Mol Biol Evol 23(12):2288–2302

    Article  CAS  PubMed  Google Scholar 

  • Avila Rodríguez MI, Barroso LGR, Sánchez ML (2018) Collagen: a review on its sources and potential cosmetic applications. J Cosmet Dermatol 17(1):20–26

    Article  PubMed  Google Scholar 

  • Ayalew L et al (2017) Conjugation of paclitaxel to hybrid peptide carrier and biological evaluation in jurkat and A549 cancer cell lines. ACS Med Chem Lett 8(8):814–819

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bächinger HP et al (2010) Collagen formation and structure. In: Comprehensive natural products II: chemistry and biology. Elsevier, Amsterdam, pp 469–530

    Chapter  Google Scholar 

  • Bama P et al (2010) Extraction of collagen from cat fish (Tachysurus maculatus) by pepsin digestion and preparation and characterization of collagen chitosan sheet. Int J Pharm Pharm Sci 2(4):133–137

    CAS  Google Scholar 

  • Barrington K, Chopin T, Robinson S (2009) Integrated multi-trophic aquaculture (IMTA) in marine temperate waters. Integrated mariculture: a global review. In: FAO fisheries and aquaculture technical paper, vol 529. FAO, Rome, pp 7–46

    Google Scholar 

  • Barros AA et al (2015) Water and carbon dioxide: green solvents for the extraction of collagen/gelatin from marine sponges. ACS Sustain Chem Eng 3(2):254–260

    Article  CAS  Google Scholar 

  • Barzideh Z et al (2014) Isolation and characterisation of collagen from the ribbon jellyfish (C hrysaora sp.). Int J Food Sci Technol 49(6):1490–1499

    Article  CAS  Google Scholar 

  • Bauer R et al (2011) Inhibition of collagen XVI expression reduces glioma cell invasiveness. Cell Physiol Biochem 27(3–4):217–226

    Article  CAS  PubMed  Google Scholar 

  • Benedetto CD et al (2014) Production, characterization and biocompatibility of marine collagen matrices from an alternative and sustainable source: the sea urchin Paracentrotus lividus. Mar Drugs 12(9):4912–4933

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Berchtold S et al (2015) Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma. Cancer Lett 356(2):721–732

    Article  CAS  PubMed  Google Scholar 

  • Berillis P (2015) Marine collagen: extraction and applications. In: Madhukar S (ed) Research trends in biochemistry, molecular biology and microbiology, pp 1–13

    Google Scholar 

  • Bermueller C et al (2013) Marine collagen scaffolds for nasal cartilage repair: prevention of nasal septal perforations in a new orthotopic rat model using tissue engineering techniques. Tissue Eng A 19(19–20):2201–2214

    Article  CAS  Google Scholar 

  • Bishop PN (2010) Molecular composition of the vitreous and aging changes. In: Dartt DA (ed) Encyclopedia of the eye. Academic Press, Oxford, pp 37–43

    Chapter  Google Scholar 

  • Borza D-B et al (2001) The NC1 domain of collagen IV encodes a novel network composed of the α1, α2, α5, and α6 chains in smooth muscle basement membranes. J Biol Chem 276(30):28532–28540

    Article  CAS  PubMed  Google Scholar 

  • Brotz L, Pauly D (2012) Jellyfish populations in the Mediterranean Sea. Acta Adriat 53(2):213–232

    Google Scholar 

  • Bruckner P (2010) Suprastructures of extracellular matrices: paradigms of functions controlled by aggregates rather than molecules. Cell Tissue Res 339(1):7–18

    Article  CAS  PubMed  Google Scholar 

  • Calejo M, Morais Z, Fernandes A (2009) Isolation and biochemical characterisation of a novel collagen from Catostylus tagi. J Biomater Sci Polym Ed 20(14):2073–2087

    Article  CAS  PubMed  Google Scholar 

  • Calejo MT, Almeida AJ, Fernandes AI (2012) Exploring a new jellyfish collagen in the production of microparticles for protein delivery. J Microencapsul 29(6):520–531

    Article  CAS  PubMed  Google Scholar 

  • Canty EG et al (2004) Coalignment of plasma membrane channels and protrusions (fibripositors) specifies the parallelism of tendon. J Cell Biol 165(4):553–563

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cao H et al (2015) Fish collagen-based scaffold containing PLGA microspheres for controlled growth factor delivery in skin tissue engineering. Colloids Surf B: Biointerfaces 136:1098–1106

    Article  CAS  PubMed  Google Scholar 

  • Chen B et al (2007) Homogeneous osteogenesis and bone regeneration by demineralized bone matrix loading with collagen-targeting bone morphogenetic protein-2. Biomaterials 28(6):1027–1035

    Article  CAS  PubMed  Google Scholar 

  • Chen S-Y, Lin J-S, Yang B-C (2014) Modulation of tumor cell stiffness and migration by type IV collagen through direct activation of integrin signaling pathway. Arch Biochem Biophys 555:1–8

    Article  PubMed  CAS  Google Scholar 

  • Cheng X et al (2017) Isolation, characterization and evaluation of collagen from jellyfish Rhopilema esculentum Kishinouye for use in hemostatic applications. PLoS One 12(1):e0169731

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chi C-F et al (2014) Antioxidant and functional properties of collagen hydrolysates from Spanish mackerel skin as influenced by average molecular weight. Molecules 19(8):11211–11230

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Cohen AH (2012) Collagen type III glomerulopathies. Adv Chronic Kidney Dis 19(2):101–106

    Article  PubMed  Google Scholar 

  • Condon RH et al (2013) Recurrent jellyfish blooms are a consequence of global oscillations. Proc Natl Acad Sci 110(3):1000–1005

    Article  CAS  PubMed  Google Scholar 

  • Connes R, Diaz J, Paris J (1972) Seasonal variation and cellular population of sponge Superities massa Nardo. In: Cytological and histological study. 3rd Series Bulletin of the Natural History Museum, vol 84. Natural History Museum, Paris, pp 1013–1038

    Google Scholar 

  • Coppola D et al (2020) Marine collagen from alternative and sustainable sources: extraction, processing and applications. Mar Drugs 18(4):214

    Article  CAS  PubMed Central  Google Scholar 

  • Cui X et al (2018) Hacking macrophage-associated immunosuppression for regulating glioblastoma angiogenesis. Biomaterials 161:164–178

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Diehl-Seifert B et al (1985) Attachment of sponge cells to collagen substrata: effect of a collagen assembly factor. J Cell Sci 79(1):271–285

    Article  CAS  PubMed  Google Scholar 

  • Discher DE et al (2017) Matrix mechanosensing: from scaling concepts in ‘omics data to mechanisms in the nucleus, regeneration, and cancer. Annu Rev Biophys 46:295–315

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Egerbacher M, Weber H, Hauer S (2000) Bones in the heart skeleton of the otter (Lutra lutra). J Anat 196(Pt 3):485–491

    Article  PubMed  PubMed Central  Google Scholar 

  • Ehrlich H, Worch H (2007) Collagen: a huge matrix in glass sponge flexible spicules of the meter-long Hyalonema sieboldi. In: Handbook of biomineralization: biological aspects and structure formation. Wiley-VCH, Weinheim, pp 22–41

    Chapter  Google Scholar 

  • Esbona K et al (2016) COX-2 modulates mammary tumor progression in response to collagen density. Breast Cancer Res 18(1):35

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Falkenhaug T (2014) Review of jellyfish blooms in the Mediterranean and Black Sea. Taylor & Francis, New York, NY

    Book  Google Scholar 

  • Felician FF et al (2018) Collagen from marine biological sources and medical applications. Chem Biodivers 15(5):e1700557

    Article  PubMed  CAS  Google Scholar 

  • Ferrario C et al (2017) Marine-derived collagen biomaterials from echinoderm connective tissues. Mar Environ Res 128:46–57

    Article  CAS  PubMed  Google Scholar 

  • Ferreira AM et al (2012) Collagen for bone tissue regeneration. Acta Biomater 8(9):3191–3200

    Article  CAS  PubMed  Google Scholar 

  • Fosgerau K, Hoffmann T (2015) Peptide therapeutics: current status and future directions. Drug Discov Today 20(1):122–128

    Article  CAS  PubMed  Google Scholar 

  • Franzke CW, Bruckner P, Bruckner-Tuderman L (2005) Collagenous transmembrane proteins: recent insights into biology and pathology. J Biol Chem 280(6):4005–4008

    Article  CAS  PubMed  Google Scholar 

  • García-Mendoza MG et al (2016) Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment. Breast Cancer Res 18(1):49

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Garrone R, Huc A, Junqua S (1975) Fine structure and physicochemical studies on the collagen of the marine sponge Chondrosia reniformis Nardo. J Ultrastruct Res 52(2):261–275

    Article  CAS  PubMed  Google Scholar 

  • Gautieri A et al (2017) Advanced glycation end-products: mechanics of aged collagen from molecule to tissue. Matrix Biol 59:95–108

    Article  CAS  PubMed  Google Scholar 

  • Girotti MR et al (2011) SPARC promotes cathepsin B-mediated melanoma invasiveness through a collagen I/α2β1 integrin axis. J Investig Dermatol 131(12):2438–2447

    Article  CAS  PubMed  Google Scholar 

  • Goh KL, Holmes DF (2017) Collagenous extracellular matrix biomaterials for tissue engineering: lessons from the common sea urchin tissue. Int J Mol Sci 18(5):901

    Article  PubMed Central  CAS  Google Scholar 

  • Guo H, Hong Z, Yi R (2015) Core-shell collagen peptide chelated calcium/calcium alginate nanoparticles from fish scales for calcium supplementation. J Food Sci 80(7):N1595–N1601

    Article  CAS  PubMed  Google Scholar 

  • Han S-H et al (2011) Effect of collagen and collagen peptides from bluefin tuna abdominal skin on cancer cells. Health 3(3):4

    Article  CAS  Google Scholar 

  • Hayashido Y et al (2014) Overexpression of integrin αv facilitates proliferation and invasion of oral squamous cell carcinoma cells via MEK/ERK signaling pathway that is activated by interaction of integrin αvβ8 with type I collagen. Int J Oncol 45(5):1875–1882

    Article  CAS  PubMed  Google Scholar 

  • Heinemann S et al (2007) Ultrastructural studies on the collagen of the marine sponge Chondrosia reniformis Nardo. Biomacromolecules 8(11):3452–3457

    Article  CAS  PubMed  Google Scholar 

  • Hernandez-Izquierdo V, Krochta J (2008) Thermoplastic processing of proteins for film formation—a review. J Food Sci 73(2):R30–R39

    Article  CAS  PubMed  Google Scholar 

  • Hodgson L, Henderson AJ, Dong C (2003) Melanoma cell migration to type IV collagen requires activation of NF-κ B. Oncogene 22(1):98–108

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Holmes DF, Kadler KE (2006) The 10+4 microfibril structure of thin cartilage fibrils. Proc Natl Acad Sci U S A 103(46):17249–17254

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hsieh Y-HP (2005) Use of jellyfish collagen (type II) in the treatment of rheumatoid arthritis. Google Patents

    Google Scholar 

  • Hurskainen M et al (2010) Recombinant human collagen XV regulates cell adhesion and migration. J Biol Chem 285(8):5258–5265

    Article  CAS  PubMed  Google Scholar 

  • Ibbetson SJ et al (2013) Mechanotransduction pathways promoting tumor progression are activated in invasive human squamous cell carcinoma. Am J Pathol 183(3):930–937

    Article  CAS  PubMed  Google Scholar 

  • Ishikawa H et al (1999) Immunohistological distributions of fibronectin, tenascin, type I, III and IV collagens, and laminin during tooth development and degeneration in fetuses of minke whale, Balaenoptera acutorostrata. J Vet Med Sci 61(3):227–232

    Article  CAS  PubMed  Google Scholar 

  • Jeevithan E et al (2015) Purification, characterization and antioxidant properties of low molecular weight collagenous polypeptide (37 kDa) prepared from whale shark cartilage (Rhincodon typus). J Food Sci Technol 52(10):6312–6322

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jia Y et al (2012) Biochemical properties of skin collagens isolated from black carp (Mylopharyngodon piceus). Food Sci Biotechnol 21(6):1585–1592

    Article  CAS  Google Scholar 

  • Kadler KE et al (2007) Collagens at a glance. J Cell Sci 120(Pt 12):1955–1958

    Article  CAS  PubMed  Google Scholar 

  • Kadler KE, Hill A, Canty-Laird EG (2008) Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators. Curr Opin Cell Biol 20(5):495–501

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kalamajski S, Oldberg A (2010) The role of small leucine-rich proteoglycans in collagen fibrillogenesis. Matrix Biol 29(4):248–253

    Article  CAS  PubMed  Google Scholar 

  • Karsdal M (2019) Biochemistry of collagens, laminins and elastin: structure, function and biomarkers. Academic Press, New York, NY

    Google Scholar 

  • Kassner A et al (2003) Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils. Matrix Biol 22(2):131–143

    Article  CAS  PubMed  Google Scholar 

  • Kaur J, Reinhardt DP (2015) Chapter 3 - Extracellular matrix (ECM) molecules. In: Vishwakarma A et al (eds) Stem cell biology and tissue engineering in dental sciences. Academic Press, Boston, MA, pp 25–45

    Chapter  Google Scholar 

  • Khong NM et al (2016) Nutritional composition and total collagen content of three commercially important edible jellyfish. Food Chem 196:953–960

    Article  CAS  PubMed  Google Scholar 

  • Khong NM et al (2018) Improved collagen extraction from jellyfish (Acromitus hardenbergi) with increased physical-induced solubilization processes. Food Chem 251:41–50

    Article  CAS  PubMed  Google Scholar 

  • Khoshnoodi J et al (2006) Molecular recognition in the assembly of collagens: terminal noncollagenous domains are key recognition modules in the formation of triple helical protomers. J Biol Chem 281(50):38117–38121

    Article  CAS  PubMed  Google Scholar 

  • Kimura S, Ohno Y (1987) Fish type I collagen: tissue-specific existence of two molecular forms, (α1) 2α2 and α1α2α3, in alaska pollack. Compar Biochem Physiol Part B Compar Biochem 88(2):409–413

    Article  Google Scholar 

  • Kimura S, Miura S, Park YH (1983) Collagen as the major edible component of jellyfish (Stomolophus nomural). J Food Sci 48(6):1758–1760

    Article  CAS  Google Scholar 

  • Kimura S et al (1993) Molecular characterization of fibrillar collagen from the body wall of starfish Asterias amurensis. Compar Biochem Physiol Part B Compar Biochem 104(4):663–668

    Article  Google Scholar 

  • KoÅ‚odziejska I, Sikorski ZE, Niecikowska C (1999) Parameters affecting the isolation of collagen from squid (Illex argentinus) skins. Food Chem 66(2):153–157

    Article  Google Scholar 

  • Kozlowska J et al (2015) Northern pike (Esox lucius) collagen: extraction, characterization and potential application. Int J Biol Macromol 81:220–227

    Article  CAS  PubMed  Google Scholar 

  • Lambshead PJD, Schalk PH (2001) Invertebrates, marine, overview. In: Levin SA (ed) Encyclopedia of biodiversity, 2nd edn. Academic Press, Waltham, MA, pp 379–391

    Chapter  Google Scholar 

  • Langasco R et al (2017) Natural collagenic skeleton of marine sponges in pharmaceutics: innovative biomaterial for topical drug delivery. Mater Sci Eng C 70:710–720

    Article  CAS  Google Scholar 

  • Li X et al (2013) Promotion of neuronal differentiation of neural progenitor cells by using EGFR antibody functionalized collagen scaffolds for spinal cord injury repair. Biomaterials 34(21):5107–5116

    Article  CAS  PubMed  Google Scholar 

  • Liang J et al (2010) Marine collagen peptides prepared from chum salmon (Oncorhynchus keta) skin extend the life span and inhibit spontaneous tumor incidence in Sprague-Dawley Rats. J Med Food 13(4):757–770

    Article  CAS  PubMed  Google Scholar 

  • Liang H et al (2015) A collagen-binding EGFR single-chain Fv antibody fragment for the targeted cancer therapy. J Control Release 209:101–109

    Article  CAS  PubMed  Google Scholar 

  • Lim Y-S et al (2019) Marine collagen as a promising biomaterial for biomedical applications. Mar Drugs 17(8):467

    Article  CAS  PubMed Central  Google Scholar 

  • Lin H et al (2006) The effect of collagen-targeting platelet-derived growth factor on cellularization and vascularization of collagen scaffolds. Biomaterials 27(33):5708–5714

    Article  CAS  PubMed  Google Scholar 

  • Luca S et al (2020) Marine collagen and its derivatives: versatile and sustainable bio-resources for healthcare. Mater Sci Eng C 113:110963

    Article  CAS  Google Scholar 

  • Ma P-F et al (2017) Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice. J Hepatol 67(4):770–779

    Article  CAS  PubMed  Google Scholar 

  • Madsen DH et al (2011) The non-phagocytic route of collagen uptake a distinct degradation pathway. J Biol Chem 286(30):26996–27010

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Madsen DH et al (2013) M2-like macrophages are responsible for collagen degradation through a mannose receptor–mediated pathway. J Cell Biol 202(6):951–966

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Madsen DH et al (2017) Tumor-associated macrophages derived from circulating inflammatory monocytes degrade collagen through cellular uptake. Cell Rep 21(13):3662–3671

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mammoto T et al (2013) Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression. Am J Pathol 183(4):1293–1305

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Merquiol L et al (2019) Biotechnological applications of scyphomedusae. Mar Drugs 17(11):604

    Article  CAS  PubMed Central  Google Scholar 

  • Miroshnikova Y et al (2017) α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. Mol Biol Cell 28(22):2958–2977

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Miura S, Kimura S (1985) Jellyfish mesogloea collagen. Characterization of molecules as alpha 1 alpha 2 alpha 3 heterotrimers. J Biol Chem 260(28):15352–15356

    Article  CAS  PubMed  Google Scholar 

  • Miyashita T et al (2019) Spatiotemporal characteristics of fibroblasts-dependent cancer cell invasion. J Cancer Res Clin Oncol 145(2):373–381

    Article  CAS  PubMed  Google Scholar 

  • Gordon MK, Hahn RA (2010) Collagens. Cell Tissue Res 339:247–257

    Article  CAS  PubMed  Google Scholar 

  • Muliaditan T et al (2018) Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis. Nat Commun 9(1):1–15

    Article  CAS  Google Scholar 

  • Muyonga J, Cole C, Duodu K (2004) Characterisation of acid soluble collagen from skins of young and adult Nile perch (Lates niloticus). Food Chem 85(1):81–89

    Article  CAS  Google Scholar 

  • Nagai T (2004) Collagen from diamondback squid (Thysanoteuthis rhombus) outer skin. Z Naturforsch C 59(3–4):271–275

    Article  CAS  PubMed  Google Scholar 

  • Nagai T, Suzuki N (2000) Isolation of collagen from fish waste material—skin, bone and fins. Food Chem 68(3):277–281

    Article  CAS  Google Scholar 

  • Nagai T, Suzuki N (2002) Preparation and partial characterization of collagen from paper nautilus (Argonauta argo, Linnaeus) outer skin. Food Chem 76(2):149–153

    Article  CAS  Google Scholar 

  • Nagai T et al (1999) Collagen of edible jellyfish exumbrella. J Sci Food Agric 79(6):855–858

    Article  CAS  Google Scholar 

  • Nagai T et al (2000) Isolation and characterization of collagen from rhizostomous jellyfish (Rhopilema asamushi). Food Chem 70(2):205–208

    Article  CAS  Google Scholar 

  • Nagai T et al (2001) Isolation and characterisation of collagen from the outer skin waste material of cuttlefish (Sepia lycidas). Food Chem 72(4):425–429

    Article  CAS  Google Scholar 

  • Nagai T et al (2002a) Collagen of octopus Callistoctopus arakawai arm. Int J Food Sci Technol 37(3):285–289

    Article  CAS  Google Scholar 

  • Nagai T, Araki Y, Suzuki N (2002b) Collagen of the skin of ocellate puffer fish (Takifugu rubripes). Food Chem 78(2):173–177

    Article  CAS  Google Scholar 

  • Nagai T, Izumi M, Ishii M (2004) Fish scale collagen. Preparation and partial characterization. Int J Food Sci Technol 39(3):239–244

    Article  CAS  Google Scholar 

  • Nagai T, Suzuki N, Nagashima T (2008) Collagen from common minke whale (Balaenoptera acutorostrata) unesu. Food Chem 111(2):296–301

    Article  CAS  PubMed  Google Scholar 

  • Nicklas M et al (2009a) Enteric coating derived from marine sponge collagen. Drug Dev Ind Pharm 35(11):1384–1388

    Article  CAS  PubMed  Google Scholar 

  • Nicklas M et al (2009b) Preparation and characterization of marine sponge collagen nanoparticles and employment for the transdermal delivery of 17β-estradiol-hemihydrate. Drug Dev Ind Pharm 35(9):1035–1042

    Article  CAS  PubMed  Google Scholar 

  • Nomura Y et al (1996) Preparation and some properties of type I collagen from fish scales. Biosci Biotechnol Biochem 60(12):2092–2094

    Article  CAS  PubMed  Google Scholar 

  • O’Brien J et al (2010) Alternatively activated macrophages and collagen remodeling characterize the postpartum involuting mammary gland across species. Am J Pathol 176(3):1241–1255

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Öhlund D et al (2013) Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop. BMC Cancer 13(1):154

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Oliveira-Ferrer L et al (2014) c-FOS suppresses ovarian cancer progression by changing adhesion. Br J Cancer 110(3):753–763

    Article  CAS  PubMed  Google Scholar 

  • Olsen BR (1997) Collagen IX. Int J Biochem Cell Biol 29(4):555–558

    Article  CAS  PubMed  Google Scholar 

  • Omori M, Nakano E (2001) Jellyfish fisheries in Southeast Asia. Hydrobiologia 451(1–3):19–26

    Article  Google Scholar 

  • Omura Y, Urano N, Kimura S (1996) Occurrence of fibrillar collagen with structure of (α1) 2α2 in the test of sea urchin Asthenosoma ijimai. Comp Biochem Physiol B: Biochem Mol Biol 115(1):63–68

    Article  Google Scholar 

  • Pallela R, Bojja S, Janapala VR (2011) Biochemical and biophysical characterization of collagens of marine sponge, Ircinia fusca (Porifera: Demospongiae: Irciniidae). Int J Biol Macromol 49(1):85–92

    Article  CAS  PubMed  Google Scholar 

  • Paradiso F et al (2019) Marine collagen substrates for 2D and 3D ovarian cancer cell systems. Front Bioeng Biotechnol 7:343

    Article  PubMed  PubMed Central  Google Scholar 

  • Plumb DA et al (2007) Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens. J Biol Chem 282(17):12791–12795

    Article  CAS  PubMed  Google Scholar 

  • Pozzolini M et al (2012) Molecular characterization of a nonfibrillar collagen from the marine sponge Chondrosia reniformis Nardo 1847 and positive effects of soluble silicates on its expression. Mar Biotechnol 14(3):281–293

    Article  CAS  Google Scholar 

  • Purcell JE, Uye S-I, Lo W-T (2007) Anthropogenic causes of jellyfish blooms and their direct consequences for humans: a review. Mar Ecol Prog Ser 350:153–174

    Article  Google Scholar 

  • Raftery RM et al (2016) Multifunctional biomaterials from the sea: assessing the effects of chitosan incorporation into collagen scaffolds on mechanical and biological functionality. Acta Biomater 43:160–169

    Article  CAS  PubMed  Google Scholar 

  • Rahman MA (2019) Collagen of extracellular matrix from marine invertebrates and its medical applications. Mar Drugs 17(2):118

    Article  CAS  PubMed Central  Google Scholar 

  • Rastian Z et al (2018) Type I collagen from Jellyfish Catostylus mosaicus for biomaterial applications. ACS Biomater Sci Eng 4(6):2115–2125

    Article  CAS  PubMed  Google Scholar 

  • Ratzinger S et al (2011) Induction of type XVI collagen expression facilitates proliferation of oral cancer cells. Matrix Biol 30(2):118–125

    Article  CAS  PubMed  Google Scholar 

  • Regenstein J, Zhou P (2007) Collagen and gelatin from marine by-products. In: Maximising the value of marine by-products. Elsevier, Amsterdam, pp 279–303

    Chapter  Google Scholar 

  • Ricard-Blum S (2011) The collagen family. Cold Spring Harb Perspect Biol 3(1):a004978

    Article  PubMed  PubMed Central  Google Scholar 

  • Ricard-Blum S, Dublet B, Van der Rest M (2000) Unconventional collagens: types VI, VII, VIII, IX, X, XII, XIV, XVI, and XIX. Oxford University Press, Oxford

    Google Scholar 

  • Rygiel TP et al (2011) Tumor-expressed collagens can modulate immune cell function through the inhibitory collagen receptor LAIR-1. Mol Immunol 49(1–2):402–406

    Article  CAS  PubMed  Google Scholar 

  • Sadowska M, KoÅ‚odziejska I, Niecikowska C (2003) Isolation of collagen from the skins of Baltic cod (Gadus morhua). Food Chem 81(2):257–262

    Article  CAS  Google Scholar 

  • Saito M et al (2001) Complete primary structure of rainbow trout type I collagen consisting of α1 (I) α2 (I) α3 (I) heterotrimers. Eur J Biochem 268(10):2817–2827

    Article  CAS  PubMed  Google Scholar 

  • Salvatore L et al (2020) Marine collagen and its derivatives: versatile and sustainable bio-resources for healthcare. Mater Sci Eng C 113:110963

    Article  CAS  Google Scholar 

  • Scarpellini A et al (2014) Syndecan-4 knockout leads to reduced extracellular transglutaminase-2 and protects against tubulointerstitial fibrosis. J Am Soc Nephrol 25(5):1013–1027

    Article  CAS  PubMed  Google Scholar 

  • Shaw LM, Olsen BR (1991) FACIT collagens: diverse molecular bridges in extracellular matrices. Trends Biochem Sci 16(5):191–194

    Article  CAS  PubMed  Google Scholar 

  • Shen Y et al (2012) Fibrillar type I collagen matrices enhance metastasis/invasion of ovarian epithelial cancer via β1 integrin and PTEN signals. Int J Gynecol Cancer 22(8):1316

    Article  PubMed  Google Scholar 

  • Shoulders MD, Raines RT (2009) Collagen structure and stability. Annu Rev Biochem 78:929–958

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Silva TH et al (2014) Marine origin collagens and its potential applications. Mar Drugs 12(12):5881–5901

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Silva JC et al (2016) Extraction of collagen/gelatin from the marine demosponge Chondrosia reniformis (Nardo, 1847) using water acidified with carbon dioxide–process optimization. Ind Eng Chem Res 55(25):6922–6930

    Article  CAS  Google Scholar 

  • Spivey KA et al (2012) A role for collagen XXIII in cancer cell adhesion, anchorage-independence and metastasis. Oncogene 31(18):2362–2372

    Article  CAS  PubMed  Google Scholar 

  • Sprague L et al (2014) Dendritic cells: in vitro culture in two-and three-dimensional collagen systems and expression of collagen receptors in tumors and atherosclerotic microenvironments. Exp Cell Res 323(1):7–27

    Article  CAS  PubMed  Google Scholar 

  • Staser K, Yang F-C, Clapp DW (2012) Pathogenesis of plexiform neurofibroma: tumor-stromal/hematopoietic interactions in tumor progression. Ann Rev Pathol Mechan Dis 7:469–495

    Article  CAS  Google Scholar 

  • Sun L et al (2017) Characterization of acid-and pepsin-soluble collagen extracted from the skin of Nile tilapia (Oreochromis niloticus). Int J Biol Macromol 99:8–14

    Article  CAS  PubMed  Google Scholar 

  • Sundaramoorthy M et al (2002) Crystal structure of NC1 domains. Structural basis for type IV collagen assembly in basement membranes. J Biol Chem 277(34):31142–31153

    Article  CAS  PubMed  Google Scholar 

  • Swatschek D et al (2002a) Microparticles derived from marine sponge collagen (SCMPs): preparation, characterization and suitability for dermal delivery of all-trans retinol. Eur J Pharm Biopharm 54(2):125–133

    Article  CAS  PubMed  Google Scholar 

  • Swatschek D et al (2002b) Marine sponge collagen: isolation, characterization and effects on the skin parameters surface-pH, moisture and sebum. Eur J Pharm Biopharm 53(1):107–113

    Article  CAS  PubMed  Google Scholar 

  • Tan Y, Chang SK (2018) Isolation and characterization of collagen extracted from channel catfish (Ictalurus punctatus) skin. Food Chem 242:147–155

    Article  CAS  PubMed  Google Scholar 

  • Than ME et al (2002) The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link. Proc Natl Acad Sci U S A 99(10):6607–6612

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tiwari G et al (2012) Drug delivery systems: an updated review. International journal of pharmaceutical investigation 2(1):2

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tjin G et al (2017) Lysyl oxidases regulate fibrillar collagen remodelling in idiopathic pulmonary fibrosis. Dis Model Mech 10(11):1301–1312

    Article  PubMed  PubMed Central  Google Scholar 

  • Tziveleka L-A et al (2017) Collagen from the marine sponges Axinella cannabina and Suberites carnosus: isolation and morphological, biochemical, and biophysical characterization. Mar Drugs 15(6):152

    Article  PubMed Central  CAS  Google Scholar 

  • Vanacore RM et al (2005) Identification of S-hydroxylysyl-methionine as the covalent cross-link of the noncollagenous (NC1) hexamer of the alpha1alpha1alpha2 collagen IV network: a role for the post-translational modification of lysine 211 to hydroxylysine 211 in hexamer assembly. J Biol Chem 280(32):29300–29310

    Article  CAS  PubMed  Google Scholar 

  • Vaniotis G et al (2018) Collagen IV-conveyed signals can regulate chemokine production and promote liver metastasis. Oncogene 37(28):3790–3805

    Article  CAS  PubMed  Google Scholar 

  • Veeruraj A et al (2012) Isolation and characterization of drug delivering potential of type-I collagen from eel fish Evenchelys macrura. J Mater Sci Mater Med 23(7):1729–1738

    Article  CAS  PubMed  Google Scholar 

  • Vigneswari S et al (2016) Biomacromolecule immobilization: grafting of fish-scale collagen peptides onto aminolyzed P (3HB-co-4HB) scaffolds as a potential wound dressing. Biomed Mater 11(5):055009

    Article  CAS  PubMed  Google Scholar 

  • Vlieghe P et al (2010) Synthetic therapeutic peptides: science and market. Drug Discov Today 15(1–2):40–56

    Article  CAS  PubMed  Google Scholar 

  • Wakabayashi K et al (2016) Differences in the biochemical compositions of two dietary jellyfish species and their effects on the growth and survival of I bacus novemdentatus phyllosomas. Aquac Nutr 22(1):25–33

    Article  CAS  Google Scholar 

  • Wang L et al (2008) Isolation and characterisation of collagens from the skin, scale and bone of deep-sea redfish (Sebastes mentella). Food Chem 108(2):616–623

    Article  CAS  PubMed  Google Scholar 

  • Wang W et al (2010) Development of an injectable chitosan/marine collagen composite gel. Biomed Mater 5(6):065009

    Article  PubMed  CAS  Google Scholar 

  • Ward AG, Courts A (1977) Science and technology of gelatin. Academic Press, London

    Google Scholar 

  • Wenstrup RJ et al (2004) Type V collagen controls the initiation of collagen fibril assembly. J Biol Chem 279(51):53331–53337

    Article  CAS  PubMed  Google Scholar 

  • Widdowson JP et al (2018) In vivo comparison of jellyfish and bovine collagen sponges as prototype medical devices. J Biomed Mater Res Part B Appl Biomater 106(4):1524–1533

    Article  CAS  Google Scholar 

  • Wilkie I (2005) Mutable collagenous tissue: overview and biotechnological perspective. In: Echinodermata. Springer, New York, NY, pp 221–250

    Chapter  Google Scholar 

  • Wu JJ et al (2010) Type III collagen, a fibril network modifier in articular cartilage. J Biol Chem 285(24):18537–18544

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xu S et al (2019) The role of collagen in cancer: from bench to bedside. J Transl Med 17(1):309

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yamada S et al (2014) Potency of fish collagen as a scaffold for regenerative medicine. Biomed Res Int 2014:302932

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Yamauchi M et al (2018) The fibrotic tumor stroma. J Clin Invest 128(1):16–25

    Article  PubMed  PubMed Central  Google Scholar 

  • Yasunaga M et al (2011) Cancer-stroma targeting therapy by cytotoxic immunoconjugate bound to the collagen 4 network in the tumor tissue. Bioconjug Chem 22(9):1776–1783

    Article  CAS  PubMed  Google Scholar 

  • Young EG, Lorimer J (1960) The acid-soluble collagen of cod skin. Arch Biochem Biophys 88(2):373–381

    Article  CAS  PubMed  Google Scholar 

  • Yu F et al (2018) Optimization of extraction conditions and characterization of pepsin-solubilised collagen from skin of giant croaker (Nibea japonica). Mar Drugs 16(1):29

    Article  PubMed Central  CAS  Google Scholar 

  • Zeng S-K et al (2009) Isolation and characterisation of acid-solubilised collagen from the skin of Nile tilapia (Oreochromis niloticus). Food Chem 116(4):879–883

    Article  CAS  Google Scholar 

  • Zhang G et al (2005) Development of tendon structure and function: regulation of collagen fibrillogenesis. J Musculoskelet Neuronal Interact 5(1):5–21

    CAS  PubMed  Google Scholar 

  • Zhang Q et al (2016) Comparison of collagen and gelatin extracted from the skins of Nile tilapia (Oreochromis niloticus) and channel catfish (Ictalurus punctatus). Food Biosci 13:41–48

    Article  CAS  Google Scholar 

  • Zhang Y, Liu Q, Rempel C (2018a) Processing and characteristics of canola protein-based biodegradable packaging: a review. Crit Rev Food Sci Nutr 58(3):475–485

    CAS  PubMed  Google Scholar 

  • Zhang H et al (2018b) Membrane associated collagen XIII promotes cancer metastasis and enhances anoikis resistance. Breast Cancer Res 20(1):116

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Authors and Affiliations

  1. College of Animal Science and Technology, Southwest University, Chongqing, China

    Md Kaisar Ali

  2. Advanced Materials and Bioengineering Research (AMBER), Dublin, Ireland

    Sajjad Husain Mir

  3. School of Chemistry, Trinity College Dublin, University of Dublin, Dublin, Ireland

    Sajjad Husain Mir

  4. Department of Food Science and Technology, Sam Higginbottom University of Agriculture Technology and Sciences, Allahabad, Uttar Pradesh, India

    Rozeena Parvez

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  1. Md Kaisar Ali
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  2. Sajjad Husain Mir
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  3. Rozeena Parvez
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  1. Department of Health and Family Welfare, Directorate of Health Services, Kolkata, West Bengal, India

    Sougata Jana

  2. Department of Chemistry, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India

    Subrata Jana

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Ali, M.K., Mir, S.H., Parvez, R. (2022). Marine Collagen: Promising Biomaterial in Delivery of Therapeutics for Cancer Therapy. In: Jana, S., Jana, S. (eds) Marine Biomaterials . Springer, Singapore. https://doi.org/10.1007/978-981-16-4787-1_8

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