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An Introduction to Respiratory Diseases and an Emerging Need for Efficient Drug Delivery Systems

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Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases

Abstract

Respiratory diseases, both acute or chronic and infectious or non-infectious, affect millions of people worldwide. The leading causes of morbidity and mortality due to respiratory diseases like asthma, chronic obstructive pulmonary diseases, interstitial lung diseases, cystic fibrosis (CF), respiratory infections and lung cancers impose enormous socio-economic burdens. Despite the significant improvement in understanding the mechanisms of these disease processes, only a few effective therapies have been developed, and most of the treatments reduce the symptoms but do not prevent the disease. There is a need for the development of efficacious respiratory drugs as well as the drug delivery system to reduce health care burdens and improve patient outcomes. Pulmonary drug delivery has not been fully explored, considering the increasing complexity of respiratory diseases, which demands an emerging need for suitable, effective and patient-complaint pharmaceuticals. In this chapter, we provide an overview of the burden of respiratory diseases, current treatments and limitations; a brief outline of chronic lung diseases and their pathogenic mechanisms; and the need for the development of novel and effective pulmonary drug delivery systems.

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Authors and Affiliations

  1. Intensive Care Unit, John Hunter Hospital, Newcastle, NSW, Australia

    Krishna Sunkara

  2. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, Sydney, NSW, Australia

    Meenu Mehta, Shakti D. Shukla & Kamal Dua

  3. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India

    Saurabh Satija & Parvarish Sharma

  4. School of Bioengeering and Biosciences, Lovely Professional University, Phagwara, Punjab, India

    Daljeet Singh Dhanjal

  5. School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS, Australia

    Madhur Shastri

  6. Departamento de Química Orgánica, Facultad de Química y de Farmacia, Pontificia Universidad Católica deChile, Santiago, Chile

    Flavia C. Zacconi

  7. Institute for Biological and Medical Engineering, Schools of Engineering, Medicine and Biological Sciences, Pontificia Universidad Católica de Chile, Santiago, Chile

    Flavia C. Zacconi

  8. School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India

    Kamal Dua

  9. Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden

    Venkata Sita Rama Raju Allam

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  1. Krishna Sunkara
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  9. Kamal Dua
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  10. Venkata Sita Rama Raju Allam
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Corresponding authors

Correspondence to Krishna Sunkara or Venkata Sita Rama Raju Allam .

Editor information

Editors and Affiliations

  1. Department of Life Sciences, International Medical University, Kuala Lumpur, Malaysia

    Dinesh Kumar Chellappan

  2. Regulatory Affairs Coordinator, Bioproperties Pty Ltd, Glenorie, NSW, Australia

    Kavita Pabreja

  3. School of Pharmacy, Al-Karim University, Katihar, Bihar, India

    Md. Faiyazuddin

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© 2022 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

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Sunkara, K. et al. (2022). An Introduction to Respiratory Diseases and an Emerging Need for Efficient Drug Delivery Systems. In: Chellappan, D.K., Pabreja, K., Faiyazuddin, M. (eds) Advanced Drug Delivery Strategies for Targeting Chronic Inflammatory Lung Diseases . Springer, Singapore. https://doi.org/10.1007/978-981-16-4392-7_1

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