Abstract
Celecoxib is a COX-2 inhibitor used for anti-inflammatory activity and to reduce the oral side effects, it is formulated in topical gel form. The method used for the development of the emulsomes was emulsion solvent diffusion method. The formulated celecoxib emulsomes were optimized, and the optimized celecoxib emulsomes were converted into topical gel. The physicochemical properties like SEM, DSC, FT-IR, results indicate that there is no chemical interaction between the drug and polymer. The zeta potential, particle size, entrapment efficiency of the optimized emulsomes were found to be 119.3252 nm and –16.3 mV. Optimized X1 gel by physical examination appears to be homogenous, with pH 7 ± 0.2 and viscosity 8,640cps, and with 98.3% of drug content. The cumulative percentage of drug release was found both between the in-vivo and ex-vivo levels and ex-vivo skin permeation studies found that the release was 95% for 4 h. The gels that were prepared were subjected to pharmacokinetic and pharmacodynamic studies. The in-vivo pharmacokinetic and dynamic results showed that the emulsomal gel has shown effective inhibition of inflammation. The significant activity (p < 0.05) was exhibited by Celecoxib-loaded emulsomal gel when it is compared to the marketed formulation (Voveran Emulgel).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Flückiger FA, Hanbury D (1996) Pharmacographia: a history of the principal drugs of vegetable origin. Macmillan and Co., London, UK
Barthe GA, Jourdan PS, McIntosh CA, Mansell RL (1988) Radioimmunoassay for the quantitative determination of celecoxib and analysis of its distribution in Citrus sinensis. Phytochemistry 27:249–254
Kokkalou E, Kapetanidis I (1988) Flavonoids of the arial parts of Acinossuaveolens. Pharm Acta Helv 636:170–173
Kawaguchi K, Kikuchi S, Takayanagi K, Yoshikawa T, Kumazawa Y (1999) Colony stimulating factor inducing activity of celecoxib. Planta Med 65:365–366
Cao M, Ren L, Chen G (2017) Formulation optimization and ex vivo and in vivo evaluation of celecoxibmicroemulsion-based gel for transdermal delivery. AAPS PharmSciTech 18:60–71
Bettini R, Catellani PL, Santi P, Massimo G, Peppas NA, Colombo P (2001) Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on release rate. J Contr Release Off J Contr Release Soc 70(3):383–391
Blanco-García E, Otero-Espinar FJ, Blanco-Méndez J, Leiro-Vidal JM, Luzardo-Álvarez A (2016) Development and characterization of anti-inflammatory activity of Curcumin-loaded biodegradable microspheres with potential use in intestinal inflammatory disorders. Int J Pharm 518(1):86–104
Tuncay M, Calis S, Kas HS (2000) M 2010: In vitro and in vivo evaluation of diclofenac sodium loaded albumin microspheres. J Microencapsul 17:145–155
Blanco-García E, Otero-EspinarFJ, Blanco-Méndez J, Leiro-Vidal JM, Luzardo-Álvarez A (2016) Development and characterization of anti-inflammatory activity of Curcumin-loaded biodegradable microspheres with potential use in intestinal inflammatory disorders. Int J Pharm 518(1):86–104
Dr PBS, Mohite SK (2016) Formulation design & development of artesunate nanosponge. Eur J Pharm Med Res 3(5):206–211
Khalid. A. Anasari, Pradeep .R. Valli (2011S) fransciscotrota, Roberta cavalla Cyclodextrin based emulsomes for delivery of resebertol: invitro characterization, stability, cytotoxicityand permeation study .AAPS Pharmasci Tech 12:279–286
Swarupa Arvapally, Harini M, Harshita G, Arun Kumar A (2017) Formulation and invitro evaluation of glipizide emulsomes. AJPTR 7(3):341–361
Koçkaya EA, Selmanoğlu G, Kısmet K, Akay MT (2010) Pathological and biochemical effects of therapeutic and supratherapeutic doses of celecoxib in Wistar albino male rats. Drug and ChemToxicol. 33:410–414
Sudharshini S, Stephen Rathina Raj B, Prasantha Kumar Choudary (2010) Quantitative analysis of flutamide in bulk drug and its pharamaceutical dosage formby by using HPLC
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2021 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this paper
Cite this paper
Muzib, Y.I., Sujitha, Y.S., Ambedkar, Y.R. (2021). Celecoxib Topical Nanoemulgel: Formulation, Ex-Vivo, Pharmacodynamic, and Pharmacokinetic Studies. In: Jyothi, S., Mamatha, D.M., Zhang, YD., Raju, K.S. (eds) Proceedings of the 2nd International Conference on Computational and Bio Engineering . Lecture Notes in Networks and Systems, vol 215. Springer, Singapore. https://doi.org/10.1007/978-981-16-1941-0_30
Download citation
DOI: https://doi.org/10.1007/978-981-16-1941-0_30
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-16-1940-3
Online ISBN: 978-981-16-1941-0
eBook Packages: Intelligent Technologies and RoboticsIntelligent Technologies and Robotics (R0)