Pharmacokinetic and Pharmacodynamic Studies on Celecoxib Loaded Nanosponges Gel for Topical Delivery

Abstract

The present work objective is to formulate topical gel loaded with celecoxib nanosponges to enhance solubility and to reduce the side effects related to oral administration. Nanosponges loaded with celecoxib drug were formulated by using the emulsion solvent diffusion method. Nanosponges were subjected to various physicochemical parameters. The optimized formula of celecoxib nanosponges was loaded into gel base. The ex vivo drug release was studied by using modified Franz diffusion. Further they were subjected to pharmacokinetic and pharmacodynamic activity. The developed optimized celecoxib loaded nanosponges were analyzed by using SEM, FT-IR, DSC studies which shows that the prepared nanosponges reveals no chemical incompatibility between the polymer and drug. The size of the particle, zeta potential, and entrapment efficiency of the optimized nanosponges were found to be 240.9 nm and −1.8 mV and 98% respectively. Optimized formulation X1 of gel appears homogenous, showing pH 7 ± 0.2, viscosity 8640cps, drug content 96.4% and ex vivo skin permeation studies found to be 95% for 4 h. Pharmacokinetic and pharmacodynamic results show that the celecoxib loaded nanosponges gel is more effective compared to marketed formulation. Celecoxib loaded nanosponges gel shows significant activity (p < 0.05) compared to the Marketed formulation (voveran Emulgel).