Abstract
Estrogen, a steroidal hormone has extensive biological activities and the effect is pleiotropic, affecting multiple systems in the body. Estrogens, the primary female sex hormones function to regulate the reproductive system by binding to specific receptors, the estrogen receptors (ERs). These ERs in turn control the expression of various genes by activating various transcriptional processes or signaling pathways. Given the importance of the role of estrogen in human physiology, they are also found to be involved in the development or control of several diseases which include but not limited to cancer, neurological disorders, obesity, gastrointestinal disorders, osteoporosis, cardiovascular diseases, inflammatory disease, etc. With support from many sophisticated studies, we provide insights on the importance of estrogen in human diseases. We reviewed here the role and the mechanisms of estrogen and its receptors that play a role in the development of severity in several diseases.
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This study was supported by the grants from the National Cancer Institute of the National Institutes of Health under award numbers SC1CA193758 and U54CA118638, and by the Department of Defense under award number W81XWH1810429.
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Singh, S.K., Singh, R. (2021). Estrogen Signaling Based Current and Potential Therapies Against Obesity and Related Diseases. In: Kumar, S., Gupta, S. (eds) Obesity and Cancer. Springer, Singapore. https://doi.org/10.1007/978-981-16-1846-8_15
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