Abstract
Along with the development of science and technology, there are more and more detecting methods in clinic. Microfluidic chip is one of them. Microfluidic chip, a technique to control tiny amounts of liquid, has fast development in the past two or three decades. It has already been applied to detect nucleic acid, proteins, cell culture, cell selection and drug screening, and so on. It provides us an accurate, high throughput, and easy integrated platform for biomarker detection and research.
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References
Manz A, Graber N, Widmer HM. Miniaturized total chemical analysis systems: a novel concept for chemical sensing. Sensors Actuators B Chem. 1990;1:244–8.
Burns MA, Johnson BN, Brahmasandra SN, et al. An integrated nanoliter DNA analysis device. Science. 1998;282:484–7.
Alam MK, Koomson E, Zou H, et al. Recent advances in microfluidic technology for manipulation and analysis of biological cells (2007–2017). Anal Chim Acta. 2018;31:29–65.
Sackmann EK, Fulton AL, Beebe DJ. The present and future role of microfluidics in biomedical research. Nature. 2014;507:181–9.
Dincer C, Bruch R, Kling A, et al. Multiplexed point-of-care testing—xPOCT. Trends Biotechnol. 2017;35:728–42.
Eletxigerra U, Martinez-Perdiguero J, Merino S. Disposable microfluidic immuno-biochip for rapid electrochemical detection of tumor necrosis factor alpha biomarker. Sensors Actuators B Chem. 2015;221:1406–11.
Gao R, Ko J, Cha K, et al. Fast and sensitive detection of an anthrax biomarker using SERS-based solenoid microfluidic sensor. Biosens Bioelectron. 2015;72:230–6.
Zhao Z, Yang Y, Zeng Y, et al. A microfluidic ExoSearch chip for multiplexed exosome detection towards blood-based ovarian cancer diagnosis. Lab Chip. 2016;16:489–96.
Sonker M, Sahore V, Woolley AT. Recent advances in microfluidic sample preparation and separation techniques for molecular biomarker analysis: a critical review. Anal Chim Acta. 2017;986:1–11.
Shameli SM, Ren CL. Microfluidic two-dimensional separation of proteins combining temperature gradient focusing and sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Anal Chem. 2015;87:3593–7.
Wu R, Seah YP, Wang Z. Microfluidic chip for stacking, separation and extraction of multiple DNA fragments. J Chromatogr A. 2016;1437:219–25.
Salafi T, Zeming KK, Zhang Y. Advancements in microfluidics for nanoparticle separation. Lab Chip. 2016;17:11–33.
Liao Z, Wang J, Zhang P, et al. Recent advances in microfluidic chip integrated electronic biosensors for multiplexed detection. Biosens Bioelectron. 2018;121:272–80.
Liao Z, Zhang Y, Li Y, et al. Microfluidic chip coupled with optical biosensors for simultaneous detection of multiple analytes: a review. Biosens Bioelectron. 2019;126:697–706.
Cooper MA. Optical biosensors: where next and how soon? Drug Discov Today. 2006;11:1061–7.
Li H, Fang X, Cao H, et al. Paper-based fluorescence resonance energy transfer assay for directly detecting nucleic acids and proteins. Biosens Bioelectron. 2016;80:79–83.
Chen P, Chung MT, McHugh W, et al. Multiplex serum cytokine immunoassay using nanoplasmonic biosensor microarrays. ACS Nano. 2015;9:4173–81.
Barani A, Paktinat H, Janmaleki M, et al. Microfluidic integrated acoustic waving for manipulation of cells and molecules. Biosens Bioelectron. 2016;85:714–25.
Hoffman AS. Hydrogels for biomedical applications. Adv Drug Deliv Rev. 2012;64:18–23.
Cheng S-Y, Heilman S, Wasserman M, et al. A hydrogel-based microfluidic device for the studies of directed cell migration. Lab Chip. 2007;7:763–9.
Martinez AW, Phillips ST, Butte MJ, et al. Patterned paper as a platform for inexpensive, low-volume, portable bioassays. Angew Chem Int Ed Engl. 2007;46:1318–20.
Ren KN, Zhou JH, Wu HK. Materials for microfluidic chip fabrication. Acc Chem Res. 2013;46(11):2396–406.
Ruiz SA, Chen CS. Microcontact printing: a tool to pattern. Soft Matter. 2007;3:168–77.
Salafi T, Zeming KK, Zhang Y. Advancements in microfluidics for nanoparticle separation. Lab Chip. 2017;17:11–33.
Becker H, Gärtner C. Polymer microfabrication methods for microfluidic analytical applications. Electrophoresis. 2000;21:12–26.
Xia Y, Mrksich M, Kim E, et al. Microcontact printing of octadecylsiloxane on the surface of silicon dioxide and its application in microfabrication. J Am Chem Soc. 1995;117:9576–7.
Sim JY, Choi JH, Lim JM, et al. Microfluidic molding of photonic microparticles with engraved elastomeric membranes. Small. 2014;10:3979–85.
Huang GY, Zhou LH, Zhang QC, et al. Microfluidic hydrogels for tissue engineering. Biofabrication. 2011;3:012001.
Ullah F, Othman MBH, Javed F, et al. Classification, processing and application of hydrogels: a review. Mater Sci Eng C Mater Biol Appl. 2015;57:414–33.
Carrilho E, Martinez AW, Whitesides GM. Understanding wax printing: a simple micropatterning process for paper-based microfluidics. Anal Chem. 2009;81:7091–5.
Bruzewicz DA, Reches M, Whitesides GM. Low-cost printing of poly (dimethylsiloxane) barriers to define microchannels in paper. Anal Chem. 2008;80:3387–92.
Abe K, Suzuki K, Citterio D. Inkjet-printed microfluidic multianalyte chemical sensing paper. Anal Chem. 2008;80:6928–34.
Yu J, Wang S, Ge L, et al. A novel chemiluminescence paper microfluidic biosensor based on enzymatic reaction for uric acid determination. Biosens Bioelectron. 2011;26:3284–9.
Delaney JL, Hogan CF, Tian J, et al. Electrogenerated chemiluminescence detection in paper-based microfluidic sensors. Anal Chem. 2011;83:1300–6.
Teh S-Y, Lin R, Hung L-H, et al. Droplet microfluidics. Lab Chip. 2008;8:198–220.
Huang H, Densmore D. Integration of microfluidics into the synthetic biology design flow. Lab Chip. 2014;14:3459–74.
Samiei E, Tabrizian M, Hoorfar M. A review of digital microfluidics as portable platforms for lab-on a-chip applications. Lab Chip. 2016;16:2376–96.
Sista RS, Eckhardt AE, Srinivasan V, et al. Heterogeneous immunoassays using magnetic beads on a digital microfluidic platform. Lab Chip. 2008;8:2188–96.
Wu J, He ZY, Chen QS, Lin JM. Biochemical analysis on microfluidic chips. Trends Anal Chem. 2016;80:213–31.
Guo WP, Shang YX, Pan LT, et al. Analysis of glycosylation hemoglobin by microfluidic chip-capillary electrophoresis. Shenzhen J Integ Trad Chin West Med. 2018;28:1–3.
Redman EA, Ramos-Payan M, Mellors JS, et al. Analysis of hemoglobin Glycation using microfluidic CE-MS: a rapid, mass spectrometry compatible method for assessing diabetes management. Anal Chem. 2016;88:5324–30.
Moschou D, Vourdas N, Kokkoris G, et al. All-plastic, low-power, disposable, continuous-flow PCR chip with integrated microheaters for rapid DNA amplification. Sensors Actuators B Chem. 2014;199:470–8.
Strohmeier O, Laßmann S, Riedel B, et al. Multiplex genotyping of KRAS point mutations in tumor cell DNA by allele-specific real-time PCR on a centrifugal microfluidic disk segment. Microchim Acta. 2013;181:1681–8.
Gan W, Gu Y, Han J, et al. Chitosan-modified filter paper for nucleic acid extraction and “in situ PCR” on a thermoplastic microchip. Anal Chem. 2017;89:3568–75.
Lund HL, Hughesman CB, Fakhfakh K, et al. Initial diagnosis of ALK-positive non-small-cell lung cancer based on analysis of ALK status utilizing droplet digital PCR. Anal Chem. 2016;88:4879–85.
Ramirez JD, Herrera G, Hernandez C, et al. Evaluation of the analytical and diagnostic performance of a digital droplet polymerase chain reaction (ddPCR) assay to detect Trypanosoma cruzi DNA in blood samples. PLoS Negl Trop Dis. 2018;12:e0007063.
Orsini P, Impera L, Parciante E, et al. Droplet digital PCR for the quantification of Alu methylation status in hematological malignancies. Diagn Pathol. 2018;13:98.
Fang X, Chen H, Yu S, et al. Predicting viruses accurately by a multiplex microfluidic loop-mediated isothermal amplification chip. Anal Chem. 2011;83:690–5.
Fang X, Chen H, Xu L, et al. A portable and integrated nucleic acid amplification microfluidic chip for identifying bacteria. Lab Chip. 2012;12:1495–9.
Yuan D, Kong J, Li X, et al. Colorimetric LAMP microfluidic chip for detecting three allergens: peanut, sesame and soybean. Sci Rep. 2018;8:8682.
Wu L, Garrido-Maestu A, Guerreiro JRL, et al. Amplification-free SERS analysis of DNA mutation in cancer cells with single-base sensitivity. Nanoscale. 2019;11:7781–9.
Cao G, Kong J, Xing Z, et al. Rapid detection of CALR type 1 and type 2 mutations using PNA-LNA clamping loop-mediated isothermal amplification on a CD-like microfluidic chip. Anal Chim Acta. 2018;1024:123–35.
Ng JK, Liu WT. Miniaturized platforms for the detection of single-nucleotide polymorphisms. Anal Bioanal Chem. 2006;386:427–34.
Wei CW, Cheng JY, Huang CT, et al. Using a microfluidic device for 1 microl DNA microarray hybridization in 500 s. Nucleic Acids Res. 2005;33:e78.
Zhang L, Cai Q, Wiederkehr RS, et al. Multiplex SNP genotyping in whole blood using an integrated microfluidic lab-on-a-chip. Lab Chip. 2016;16:4012–9.
Kukhtin AC, Sebastian T, Golova J, et al. Lab-on-a-film disposable for genotyping multidrug-resistant Mycobacterium tuberculosis from sputum extracts. Lab Chip. 2019;19:1217–25.
Jung YK, Kim J, Mathies RA. Microfluidic hydrogel arrays for direct genotyping of clinical samples. Biosens Bioelectron. 2016;79:371–8.
Zhi X, Deng M, Yang H, et al. A novel HBV genotypes detecting system combined with microfluidic chip, loop-mediated isothermal amplification and GMR sensors. Biosens Bioelectron. 2014;54:372–7.
Bageritz J, Raddi G. Single-cell RNA sequencing with drop-seq. Methods Mol Biol. 2019;1979:73–85.
Maino N, Hauling T, Cappi G, et al. A microfluidic platform towards automated multiplexed in situ sequencing. Sci Rep. 2019;9:3542.
Kong SL, Li H, Tai JA, et al. Concurrent single-cell RNA and targeted DNA sequencing on an automated platform for comeasurement of genomic and transcriptomic signatures. Clin Chem. 2019;65:272–81.
Wang X, Yi L, Roper MG. Microfluidic device for the measurement of amino acid secretion dynamics from murine and human islets of langerhans. Anal Chem. 2016;88:3369–75.
Batalla P, Martin A, Lopez MA, et al. Enzyme-based microfluidic chip coupled to graphene electrodes for the detection of D-amino acid enantiomer-biomarkers. Anal Chem. 2015;87:5074–8.
Lee J, Soper SA, Murray KK. Microfluidic chips for mass spectrometry-based proteomics. J Mass Spectrom. 2009;44:579–93.
Pedde RD, Li H, Borchers CH, et al. Microfluidic-mass spectrometry interfaces for translational proteomics. Trends Biotechnol. 2017;35:954–70.
Feng X, Liu BF, Li J, et al. Advances in coupling microfluidic chips to mass spectrometry. Mass Spectrom Rev. 2015;34:535–57.
Charmet J, Arosio P, Knowles TPJ. Microfluidics for protein biophysics. J Mol Biol. 2018;430:565–80.
Chin CD, Linder V, Sia SK. Commercialization of microfluidic point-of-care diagnostic devices. Lab Chip. 2012;12:2118–34.
Fan R, Vermesh O, Srivastava A, et al. Integrated barcode chips for rapid, multiplexed analysis of proteins in microliter quantities of blood. Nat Biotechnol. 2008;26:1373–8.
Zhou Q, Lin Y, Zhang K, et al. Reduced graphene oxide/BiFeO3 nanohybrids-based signal-on photoelectrochemical sensing system for prostate-specific antigen detection coupling with magnetic microfluidic device. Biosens Bioelectron. 2018;101:146–52.
Ulum MF, Maylina L, Noviana D, et al. EDTA-treated cotton-thread microfluidic device used for one-step whole blood plasma separation and assay. Lab Chip. 2016;16:1492–504.
Cheow LF, Viswanathan R, Chin CS, et al. Multiplexed analysis of protein-ligand interactions by fluorescence anisotropy in a microfluidic platform. Anal Chem. 2014;86:9901–8.
Liu WW, Zhu Y, Fang Q. Femtomole-scale high-throughput screening of protein ligands with droplet-based thermal shift assay. Anal Chem. 2017;89:6678–85.
Choi JW, Kang DK, Park H, et al. High-throughput analysis of protein-protein interactions in picoliter-volume droplets using fluorescence polarization. Anal Chem. 2012;84:3849–54.
Srisa-Art M, Kang DK, Hong J, et al. Analysis of protein-protein interactions by using droplet-based microfluidics. Chembiochem. 2009;10:1605–11.
Yang M, Nelson R, Ros A. Toward analysis of proteins in single cells: a quantitative approach employing isobaric tags with MALDI mass spectrometry realized with a microfluidic platform. Anal Chem. 2016;88:6672–9.
Dietze C, Hackl C, Gerhardt R, et al. Chip-based electrochromatography coupled to ESI-MS detection. Electrophoresis. 2016;37:1345–52.
Kuster SK, Pabst M, Zenobi R, et al. Screening for protein phosphorylation using nanoscale reactions on microdroplet arrays. Angew Chem Int Ed Engl. 2015;54:1671–5.
Choi K, Boyacı E, Kim J, et al. A digital microfluidic interface between solid-phase microextraction and liquid chromatography–mass spectrometry. J Chromatogr A. 2016;1444:1–7.
Shih SC, Yang H, Jebrail MJ, et al. Dried blood spot analysis by digital microfluidics coupled to nanoelectrospray ionization mass spectrometry. Anal Chem. 2012;84:3731–8.
Jebrail MJ, Yang H, Mudrik JM, et al. A digital microfluidic method for dried blood spot analysis. Lab Chip. 2011;11:3218–24.
Ng AH, Uddayasankar U, Wheeler AR. Immunoassays in microfluidic systems. Anal Bioanal Chem. 2010;397:991–1007.
Henares TG, Mizutani F, Hisamoto H. Current development in microfluidic immunosensing chip. Anal Chim Acta. 2008;611:17–30.
Barbosa AI, Reis NM. A critical insight into the development pipeline of microfluidic immunoassay devices for the sensitive quantitation of protein biomarkers at the point of care. Analyst. 2017;142:858–82.
Gonzalez A, Gaines M, Gallegos LY, et al. Enzyme-linked immunosorbent assays (ELISA) based on thread, paper, and fabric. Electrophoresis. 2018;39:476–84.
Tang M, Wang G, Kong SK, et al. A review of biomedical centrifugal microfluidic platforms. Micromachines (Basel). 2016;7:26.
Preechakasedkit P, Siangproh W, Khongchareonporn N, et al. Development of an automated wax-printed paper-based lateral flow device for alpha-fetoprotein enzyme-linked immunosorbent assay. Biosens Bioelectron. 2018;102:27–32.
Yamada K, Henares TG, Suzuki K, et al. Paper-based inkjet-printed microfluidic analytical devices. Angew Chem Int Ed. 2015;54:5294–310.
Machado JMD, Soares RRG, Chu V, et al. Multiplexed capillary microfluidic immunoassay with smartphone data acquisition for parallel mycotoxin detection. Biosens Bioelectron. 2018;99:40–6.
Cui X, Liu Y, Hu D, et al. A fluorescent microbead-based microfluidic immunoassay chip for immune cell cytokine secretion quantification. Lab Chip. 2018;18:522–31.
Ng AH, Fobel R, Fobel C, et al. A digital microfluidic system for serological immunoassays in remote settings. Science translational medicine. Sci Transl Med. 2018;10:eaar6076.
Chin CD, Laksanasopin T, Cheung YK, et al. Microfluidics-based diagnostics of infectious diseases in the developing world. Nat Med. 2011;17:1015–9.
Yap LW, Chen H, Gao Y, et al. Bifunctional plasmonic-magnetic particles for an enhanced microfluidic SERS immunoassay. Nanoscale. 2017;9:7822–9.
Li W, Khan M, Mao S, et al. Advances in tumor-endothelial cells co-culture and interaction on microfluidics. J Pharm Anal. 2018;8:210–8.
Lee S, Kim H, Lee W, et al. Microfluidic-based cell handling devices for biochemical applications. J Micromech Microeng. 2018;28:123001.
Shen Y, Yalikun Y, Tanaka Y. Recent advances in microfluidic cell sorting systems. Sensors Actuators B Chem. 2019;282:268–81.
Jackson JM, Witek MA, Kamande JW, et al. Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells. Chem Soc Rev. 2017;46:4245–80.
van Duinen V, Trietsch SJ, Joore J, et al. Microfluidic 3D cell culture: from tools to tissue models. Curr Opin Biotechnol. 2015;35:118–26.
Zhao SP, Ma Y, Lou Q, et al. Three-dimensional cell culture and drug testing in a microfluidic sidewall-attached droplet array. Anal Chem. 2017;89:10153–7.
Liu Q, Wu C, Cai H, et al. Cell-based biosensors and their application in biomedicine. Chem Rev. 2014;114:6423–61.
Halldorsson S, Lucumi E, Gomez-Sjoberg R, et al. Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices. Biosens Bioelectron. 2015;63:218–31.
Rothbauer M, Zirath H, Ertl P. Recent advances in microfluidic technologies for cell-to-cell interaction studies. Lab Chip. 2018;18:249–70.
Businaro L, De Ninno A, Schiavoni G, et al. Cross talk between cancer and immune cells: exploring complex dynamics in a microfluidic environment. Lab Chip. 2013;13:229–39.
Charwat V, Rothbauer M, Tedde SF, et al. Monitoring dynamic interactions of tumor cells with tissue and immune cells in a lab-on-a-chip. Anal Chem. 2013;85:11471–8.
Zervantonakis IK, Hughes-Alford SK, Charest JL, et al. Three-dimensional microfluidic model for tumor cell intravasation and endothelial barrier function. Proc Natl Acad Sci. 2012;109:13515–20.
Choi Y, Hyun E, Seo J, et al. A microengineered pathophysiological model of early-stage breast cancer. Lab Chip. 2015;15:3350–7.
Zare RN, Kim S. Microfluidic platforms for single-cell analysis. Annu Rev Biomed Eng. 2010;12:187–201.
Wu H, Chen X, Gao X, et al. High-throughput generation of durable droplet arrays for single-cell encapsulation, culture, and monitoring. Anal Chem. 2018;90:4303–9.
Chen P, Yan S, Wang J, et al. Dynamic microfluidic cytometry for single-cell cellomics: high-throughput probing single-cell-resolution signaling. Anal Chem. 2019;91:1619–26.
Kim SC, Clark IC, Shahi P, et al. Single-cell RT-PCR in microfluidic droplets with integrated chemical lysis. Anal Chem. 2018;90:1273–9.
Damiati S, Kompella UB, Damiati SA, et al. Microfluidic devices for drug delivery systems and drug screening. Genes (Basel). 2018;9:103.
Rezvantalab S, Keshavarz Moraveji M. Microfluidic assisted synthesis of PLGA drug delivery systems. RSC Adv. 2019;9:2055–72.
Tran TH, Nguyen CT, Kim DP, et al. Microfluidic approach for highly efficient synthesis of heparin-based bioconjugates for drug delivery. Lab Chip. 2012;12:589–94.
Shembekar N, Chaipan C, Utharala R, et al. Droplet-based microfluidics in drug discovery, transcriptomics and high-throughput molecular genetics. Lab Chip. 2016;16:1314–31.
Pessi J, Santos HA, Miroshnyk I, et al. Microfluidics-assisted engineering of polymeric microcapsules with high encapsulation efficiency for protein drug delivery. Int J Pharm. 2014;472:82–7.
Riahi R, Tamayol A, Shaegh SAM, et al. Microfluidics for advanced drug delivery systems. Curr Opin Chem Eng. 2015;7:101–12.
Balbino TA, Aoki NT, Gasperini AAM, et al. Continuous flow production of cationic liposomes at high lipid concentration in microfluidic devices for gene delivery applications. Chem Eng J. 2013;226:423–33.
Schneider G. Automating drug discovery. Nat Rev Drug Discov. 2018;17:97–113.
Skardal A, Shupe T, Atala A. Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling. Drug Discov Today. 2016;21:1399–411.
Dong R, Liu Y, Mou L, et al. Microfluidics-based biomaterials and biodevices. Adv Mater. 2018;31:e1805033.
Wang YI, Abaci HE, Shuler ML. Microfluidic blood–brain barrier model provides in vivo-like barrier properties for drug permeability screening. Biotechnol Bioeng. 2017;114:184–94.
Eduati F, Utharala R, Madhavan D, et al. A microfluidics platform for combinatorial drug screening on cancer biopsies. Nat Commun. 2018;9:2434.
Miller EM, Wheeler AR. A digital microfluidic approach to homogeneous enzyme assays. Anal Chem. 2008;80:1614–9.
Mross S, Pierrat S, Zimmermann T, et al. Microfluidic enzymatic biosensing systems: a review. Biosens Bioelectron. 2015;70:376–91.
Asanomi Y, Yamaguchi H, Miyazaki M, et al. Enzyme-immobilized microfluidic process reactors. Molecules. 2011;16:6041–59.
Urban PL, Goodall DM, Bruce NC. Enzymatic microreactors in chemical analysis and kinetic studies. Biotechnol Adv. 2006;24:42–57.
Colin PY, Zinchenko A, Hollfelder F. Enzyme engineering in biomimetic compartments. Curr Opin Struct Biol. 2015;33:42–51.
Xu Y, Lee JH, Li Z, et al. A droplet microfluidic platform for efficient enzymatic chromatin digestion enables robust determination of nucleosome positioning. Lab Chip. 2018;18:2583–92.
Moazami E, Perry JM, Soffer G, et al. Integration of world-to-chip interfaces with digital microfluidics for bacterial transformation and enzymatic assays. Anal Chem. 2019;91:5159–68.
Zhu Z, Yang CJ. Hydrogel droplet microfluidics for high-throughput single molecule/cell analysis. Acc Chem Res. 2017;50:22–31.
Kang D-K, Monsur Ali M, Zhang K, et al. Droplet microfluidics for single-molecule and single-cell analysis in cancer research, diagnosis and therapy. TrAC Trends Anal Chem. 2014;58:145–53.
Ven K, Vanspauwen B, Perez-Ruiz E, et al. Target confinement in small reaction volumes using microfluidic technologies: a smart approach for single-entity detection and analysis. ACS Sens. 2018;3:264–84.
Joensson HN, Andersson Svahn H. Droplet microfluidics—a tool for single-cell analysis. Angew Chem Int Ed Engl. 2012;51:12176–92.
Leng X, Zhang W, Wang C, et al. Agarose droplet microfluidics for highly parallel and efficient single molecule emulsion PCR. Lab Chip. 2010;10:2841–3.
Zhang H, Jenkins G, Zou Y, et al. Massively parallel single-molecule and single-cell emulsion reverse transcription polymerase chain reaction using agarose droplet microfluidics. Anal Chem. 2012;84:3599–606.
Li X, Zhang D, Zhang H, et al. Microwell array method for rapid generation of uniform agarose droplets and beads for single molecule analysis. Anal Chem. 2018;90:2570–7.
Duan BK, Cavanagh PE, Li X, et al. Ultrasensitive single-molecule enzyme detection and analysis using a polymer microarray. Anal Chem. 2018;90:3091–8.
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Fang, X. (2021). Microfluidic Chip. In: Pan, S., Tang, J. (eds) Clinical Molecular Diagnostics. Springer, Singapore. https://doi.org/10.1007/978-981-16-1037-0_26
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