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Functional Dendritic Coatings for Biomedical Implants

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Emerging Trends in Nanomedicine

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Abstract

Dendrimers are class of highly branched nanostructures, consisting of a central core, a branched dendritic interior, and an exterior surface possessing multiple functional groups. Their well-defined compact size and shape, multivalent nature, and a high degree of molecular uniformity make them preferred choice of candidates for various biomedical and engineering applications. Dendrimers are utilized for biomedical implant coatings, solubility enhancement, drug-delivery systems, chemical sensors, medical diagnostics, catalysts, separation agents, high-performance polymers, building blocks of supermolecules and, etc. The unique property of dendritic macromolecules, in combination with the other characteristics, have shown significant potential as functional coatings for biomedical implants. These have been utilized in the form of (1) composite, (2) soft coating materials, and (3) template for fabricating biomedical implants. The dendrimer incorporated with implant have offered multifunctional roles including drug loading, antibacterial film, passivating layer, biocompatibility, and osseointegration, etc. This chapter discusses the current state-of-art on various applications of dendrimer for design and development of biomedical implants, wherein the main focus is on properties of dendrimer and their functional advantages. The strategies for fabricating the dendritic soft coating on various types of biomedical implant substrates and the development of dendritic nanocomposites, for their use as biomedical implants, will also be highlighted.

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Authors and Affiliations

  1. School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India

    Jobin Thomas & Sangeeta Yadav

  2. Centre for Nanobiotechnology, Vellore Institute of Technology, Vellore, Tamil Nadu, India

    Jitendra Satija

  3. Department of Agriculture and Environmental Sciences, National Institute of Food Technology Entrepreneurship and Management, Sonepat, Haryana, India

    Shekhar Agnihotri

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  1. Nanomaterials and Toxicology Lab, Division of Biological and Life Sciences, School of Arts and Sciences, Central Campus, Ahmedabad University, Ahmedabad, Gujarat, India

    Sanjay Singh

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Thomas, J., Yadav, S., Satija, J., Agnihotri, S. (2021). Functional Dendritic Coatings for Biomedical Implants. In: Singh, S. (eds) Emerging Trends in Nanomedicine. Springer, Singapore. https://doi.org/10.1007/978-981-15-9920-0_6

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