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Translational Studies of Nanofibers-Based Scaffold for Skin and Bone Tissue Regeneration

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Emerging Trends in Nanomedicine

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Abstract

The area regenerative medicine targets to recreate, repair or replace the damaged body part into functional human tissue. Tissue engineering is a part of regenerative medicine that utilizes the principles and methods of engineering for the development of biological substitutes that can restore or improve the function of damaged tissues. It involves scaffolds combined with cells, growth factors or suitable biochemical signals promoting the growth and regeneration of damaged tissues and organs. Scaffolds are three-dimensional structure that mimics the native extracellular matrix (ECM) properties and provides structural support to the cells to regenerate. Several approaches have been developed for the fabrication of natural or synthetic polymer-based 3D scaffolds. Among them, nanofibers have been evaluated as promising tissue engineering scaffolds since they mimic the nanoscale properties of the native extracellular matrix and has high surface area to volume ratio. These features favors cell adhesion, proliferation, and differentiation which are highly desired for tissue engineering applications. This chapter summarizes the nanofibers’ innovative approaches used to mimic ECM properties and their potential applications for the skin and bone tissue engineering. Also, the successful translational studies of nanofibers for in vivo skin and bone regeneration have been elaborated in detail.

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Acknowledgement

Authors acknowledge financial support from SERB [EEQ/2017/000836], DST, Govt. of India; Nanomission [SR/NM/NB-1079/2017 (G)], DST, Govt. of India; CSIR JRF for the present work.

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Authors and Affiliations

  1. Biomaterials & Biomimetics Laboratory, School of Life Sciences, Central University of Gujarat, Gandhinagar, India

    Unnati Modi, Dhaval Kedaria, Bindiya Dhimmar & Rajesh Vasita

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  1. Unnati Modi
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  2. Dhaval Kedaria
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  3. Bindiya Dhimmar
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  4. Rajesh Vasita
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  1. Nanomaterials and Toxicology Lab, Division of Biological and Life Sciences, School of Arts and Sciences, Central Campus, Ahmedabad University, Ahmedabad, Gujarat, India

    Sanjay Singh

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Modi, U., Kedaria, D., Dhimmar, B., Vasita, R. (2021). Translational Studies of Nanofibers-Based Scaffold for Skin and Bone Tissue Regeneration. In: Singh, S. (eds) Emerging Trends in Nanomedicine. Springer, Singapore. https://doi.org/10.1007/978-981-15-9920-0_5

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