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The Epidemiology and Pathogenesis of Sarcoma

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Sarcoma

Abstract

Sarcomas are a group of rare malignant neoplasms of mesenchymal origin which may occur in skeletal and extraskeletal tissue, including muscles, tendons, fat, synovium, fibrous tissue, blood vessels and the peripheral nervous system [1, 2]. Tumours of soft tissue and bone are characterised by a high degree of morphological, molecular and clinical heterogeneity. Sarcomas are classified by the World Health Organization (WHO) according to histological features into over 100 types, of which at least 70% are soft tissue sarcomas [2, 3]. The classification system for sarcomas is an evolving process, reflecting the advent of novel molecular, cytogenetic and immunohistochemical techniques which facilitate the identification of groups of sarcoma cells expressing tumour-specific markers [4]. These techniques play a pivotal role in the refinement of sarcoma diagnosis, which is currently based on tumour morphology, immunohistochemistry and clinic-pathological correlation [2].

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Authors and Affiliations

  1. Department of Surgery, University of Melbourne, Melbourne, VIC, Australia

    Wassif Kabir & Peter F. M. Choong

  2. Department of Orthopaedics, St. Vincent’s Hospital Melbourne, Melbourne, VIC, Australia

    Peter F. M. Choong

  3. Bone and Soft Tissue Tumour Service, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia

    Peter F. M. Choong

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Correspondence to Peter F. M. Choong .

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  1. St. Vincent’s Hospital Melbourne, Peter MacCallum Cancer Centre and University of Melbourne Department of Surgery, Victoria, VIC, Australia

    Peter F. M. Choong

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Kabir, W., Choong, P.F.M. (2021). The Epidemiology and Pathogenesis of Sarcoma. In: Choong, P.F.M. (eds) Sarcoma . Springer, Singapore. https://doi.org/10.1007/978-981-15-9414-4_2

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