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Epigenetic Regulator Enzymes and Their Implications in Distinct Malignancies

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Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy

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Abstract

Histone protein modifications and DNA methylation come within the confines of epigenetic modifications (Jarmasz et al. 2019; Tolsma and Hansen 2019). These modifications being dynamic are perfectly tuned by the functionally antagonistic enzymes (Allis et al. 2007; Kang et al. 2017; Tian et al. 2013; Yang and Seto 2007). Histone proteins unlike DNA undergo a variety of post-translational modifications. While histone proteins undergo acetylation (Eberharter and Becker 2002), phosphorylation (Rossetto et al. 2012), methylation (Luo 2018), SUMOylation (Flotho and Melchior 2013), ubiquitination (Cao and Yan 2012), biotinylation and ADP-ribosylation (Palazzo et al. 2019), DNA undergoes only one epigenetic modification, that is methylation (Jarmasz et al. 2019).

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  1. Division of Basic Sciences and Humanities, Faculty of Agriculture, Wadura Sopore, SKUAST-Kashmir, India

    Shabir Ahmad Ganai

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Ganai, S.A. (2020). Epigenetic Regulator Enzymes and Their Implications in Distinct Malignancies. In: Histone Deacetylase Inhibitors in Combinatorial Anticancer Therapy. Springer, Singapore. https://doi.org/10.1007/978-981-15-8179-3_2

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