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LDL and HDL Oxidative Modification and Atherosclerosis

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Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1276))

Abstract

Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) are two kinds of common lipoproteins in plasma. The level of LDL cholesterol in plasma is positively correlated with atherosclerosis (AS), which is related to the complex macromolecular components, especially the easy oxygenation of protein and lipid components. However, the plasma HDL cholesterol level is negatively correlated with AS, but the results of recent studies show that the oxidative modified HDL in pathological state will not reduce and may aggravate the occurrence and development of AS. Therefore, the oxidative modification of lipoproteins is closely related to vascular homeostasis, which has become a hot research area for a long time.

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Further Reading

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  7. Shao B, Tang C, Heinecke JW et al (2010) Oxidation of apolipoprotein AI by myeloperoxidase impairs the initial interactions with ABCAl required for signaling and cholesterol export. J Lipid Res 51(7):1849–1858

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Matsuo Y, Oberbach A, Till H et al (2013) Impaired HDL function inobese adolescents: impact of lifestyle intervention and bariatric surgery. Obesity (Silver Spring) 21(12):687–695

    Article  CAS  Google Scholar 

  9. Henning MF, Herlax V, Bakas L (2011) Contribution of the Cterminalend of apolipoprotein Al to neutralization of lipopolysaccharide endotoxic effect. Innate Immunity 17(3):327–337

    Article  CAS  PubMed  Google Scholar 

  10. Brown BE, Nobecourt E, Zeng J et al (2013) Apolipoprotein AI glycationby glucose and reactive aldehydes alters phospholipid affinity but notcholesterol export from lipidladen macrophages. PLoS One 8(5):65430

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Authors and Affiliations

  1. Institute of Atherosclerosis, Shandong First Medical University, Taian, China

    Shucun Qin

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  1. Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, NY, USA

    Xian-Cheng Jiang

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Qin, S. (2020). LDL and HDL Oxidative Modification and Atherosclerosis. In: Jiang, XC. (eds) Lipid Transfer in Lipoprotein Metabolism and Cardiovascular Disease. Advances in Experimental Medicine and Biology, vol 1276. Springer, Singapore. https://doi.org/10.1007/978-981-15-6082-8_10

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