Skip to main content
SpringerLink
Log in

Interplay Between microRNAs and Other Cerebrovascular Diseases

  • Chapter
  • First Online:
IschemiRs: MicroRNAs in Ischemic Stroke

  • 227 Accesses

Abstract

Cerebrovascular disorders constitute the world’s leading cause of morbidity and mortality. The role of miRNAs in initiating and advancing cerebrovascular diseases has recently become an important focus of attention. Through this chapter, we provide a brief overview of the ever-expanding role of miRNAs as a diagnostic and therapeutic tool for cerebrovascular diseases.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Broderick JP, Brott TG, Duldner JE, Tomsick T, Huster G (1993) Volume of intracerebral hemorrhage. A powerful and easy-to-use predictor of 30-day mortality. Stroke 24(7):987–993

    Article  CAS  PubMed  Google Scholar 

  2. Zheng HW, Wang YL, Lin JX, Li N, Zhao XQ, Liu GF, Liu LP, Jiao Y, Gu WK, Wang DZ, Wang YJ (2012) Circulating MicroRNAs as potential risk biomarkers for hematoma enlargement after intracerebral hemorrhage. CNS Neurosci Ther 18(12):1003–1011

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Wijdicks EF, Sheth KN, Carter BS, Greer DM, Kasner SE, Kimberly WT, Schwab S, Smith EE, Tamargo RJ, Wintermark M, American Heart Association Stroke Council (2014) Recommendations for the management of cerebral and cerebellar infarction with swelling: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 45(4):1222–1238

    Article  PubMed  Google Scholar 

  4. Zhu Y, Wang JL, He ZY, Jin F, Tang L (2015) Association of altered serum microRNAs with perihematomal edema after acute intracerebral hemorrhage. PLoS One 10(7):e0133783

    Article  PubMed  PubMed Central  Google Scholar 

  5. Wang MD, Wang Y, Xia YP, Dai JW, Gao L, Wang SQ, Wang HJ, Mao L, Li M, Yu SM, Tu Y, He QW, Zhang GP, Wang L, Xu GZ, Xu HB, Zhu LQ, Hu B (2016) High serum MiR-130a levels are associated with severe perihematomal edema and predict adverse outcome in acute ICH. Mol Neurobiol 53(2):1310–1321

    Article  CAS  PubMed  Google Scholar 

  6. Wang Z, Lu G, Sze J, Liu Y, Lin S, Yao H, Zhang J, Xie D, Liu Q, Kung HF, Lin MC, Poon WS (2018) Plasma miR-124 is a promising candidate biomarker for human intracerebral hemorrhage stroke. Mol Neurobiol 55(7):5879–5888

    Article  CAS  PubMed  Google Scholar 

  7. Shao Z, Tu S, Shao A (2019) Pathophysiological mechanisms and potential therapeutic targets in intracerebral hemorrhage. Front Pharmacol 10:1079

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Li H, Wu J, Shen H, Yao X, Liu C, Pianta S, Han J, Borlongan CV, Chen G (2018) Autophagy in hemorrhagic stroke: mechanisms and clinical implications. Prog Neurobiol 163–164:79–97

    Article  PubMed  Google Scholar 

  9. Yang Z, Zhong L, Xian R, Yuan B (2015) MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage. Mol Immunol 65(2):267–276

    Article  CAS  PubMed  Google Scholar 

  10. Fang H, Wang PF, Zhou Y, Wang YC, Yang QW (2013) Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury. J Neuroinflammation 10:27

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Chiang EY, Yu X, Grogan JL (2011) Immune complex-mediated cell activation from systemic lupus erythematosus and rheumatoid arthritis patients elaborate different requirements for IRAK1/4 kinase activity across human cell types. J Immunol 186:1279–1288

    Article  CAS  PubMed  Google Scholar 

  12. Yuan B, Shen H, Lin L, Su T, Zhong L, Yang Z (2015) MicroRNA367 negatively regulates the inflammatory response of microglia by targeting IRAK4 in intracerebral hemorrhage. J Neuroinflammation 12:206

    Article  PubMed  PubMed Central  Google Scholar 

  13. Iwuchukwu I, Nguyen D, Sulaiman W (2016) MicroRNA profile in cerebrospinal fluid and plasma of patients with spontaneous intracerebral hemorrhage. CNS Neurosci Ther 22(12):1015–1018

    Article  PubMed  PubMed Central  Google Scholar 

  14. Yu A, Zhang T, Duan H, Pan Y, Zhang X, Yang G, Wang J, Deng Y, Yang Z (2017) MiR-124 contributes to M2 polarization of microglia and confers brain inflammatory protection via the C/EBP-α pathway in intracerebral hemorrhage. Immunol Lett 182:1–11

    Article  CAS  PubMed  Google Scholar 

  15. Zhang Y, Han B, He Y, Li D, Ma X, Liu Q, Hao J (2017) MicroRNA-132 attenuates neurobehavioral and neuropathological changes associated with intracerebral hemorrhage in mice. Neurochem Int 107:182–190

    Article  CAS  PubMed  Google Scholar 

  16. Chen Q, Xu J, Li L, Li H, Mao S, Zhang F, Zen K, Zhang CY, Zhang Q (2014) MicroRNA-23a/b and microRNA-27a/b suppress Apaf-1 protein and alleviate hypoxia-induced neuronal apoptosis. Cell Death Dis 5:e1132

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Xu W, Li F, Liu Z, Xu Z, Sun B, Cao J, Liu Y (2017) MicroRNA-27b inhibition promotes Nrf2/ARE pathway activation and alleviates intracerebral hemorrhage-induced brain injury. Oncotarget 8(41):70669–70684

    Article  PubMed  PubMed Central  Google Scholar 

  18. Xi T, Jin F, Zhu Y, Wang J, Tang L, Wang Y, Liebeskind DS, He Z (2017) MicroRNA-126-3p attenuates blood-brain barrier disruption, cerebral edema and neuronal injury following intracerebral hemorrhage by regulating PIK3R2 and Akt. Biochem Biophys Res Commun 494(1–2):144–151

    Article  CAS  PubMed  Google Scholar 

  19. Guo Q, Su H, He JB, Li HQ, Sha JJ (2018) MiR-590-5p alleviates intracerebral hemorrhage-induced brain injury through targeting Peli1 gene expression. Biochem Biophys Res Commun 504(1):61–67

    Article  CAS  PubMed  Google Scholar 

  20. Huang XP, Peng JH, Pang JW, Tian XC, Li XS, Wu Y, Li Y, Jiang Y, Sun XC (2017) Peli1 contributions in microglial activation, neuroinflammatory responses and neurological deficits following experimental subarachnoid hemorrhage. Front Mol Neurosci 10:398

    Article  PubMed  PubMed Central  Google Scholar 

  21. Xi T, Jin F, Zhu Y, Wang J, Tang L, Wang Y, Liebeskind DS, Scalzo F, He Z (2018) miR-27a-3p protects against blood-brain barrier disruption and brain injury after intracerebral hemorrhage by targeting endothelial aquaporin-11. J Biol Chem 293(52):20041–20050

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Yang Z, Jiang X, Zhang J, Huang X, Zhang X, Wang J, Shi H, Yu A (2018) Let-7a promotes microglia M2 polarization by targeting CKIP-1 following ICH. Immunol Lett 202:1–7

    Article  CAS  PubMed  Google Scholar 

  23. Lu X, Zhang HY, He ZY (2020) MicroRNA-181c provides neuroprotection in an intracerebral hemorrhage model. Neural Regen Res 15(7):1274–1282

    Article  PubMed  PubMed Central  Google Scholar 

  24. Lai NS, Zhang JQ, Qin FY, Sheng B, Fang XG, Li ZB (2017) Serum microRNAs are non-invasive biomarkers for the presence and progression of subarachnoid haemorrhage. Biosci Rep 37(1):BSR20160480

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Stylli SS, Adamides AA, Koldej RM, Luwor RB, Ritchie DS, Ziogas J, Kaye AH (2017) miRNA expression profiling of cerebrospinal fluid in patients with aneurysmal subarachnoid hemorrhage. J Neurosurg 126(4):1131–1139

    Article  CAS  PubMed  Google Scholar 

  26. Lu G, Wong MS, Xiong MZQ, Leung CK, Su XW, Zhou JY, Poon WS, Zheng VZY, Chan WY, Wong GKC (2017) Circulating microRNAs in delayed cerebral infarction after aneurysmal subarachnoid hemorrhage. J Am Heart Assoc 6(4):e005363

    Article  PubMed  PubMed Central  Google Scholar 

  27. Bache S, Rasmussen R, Rossing M, Laigaard FP, Nielsen FC, Møller K (2017) MicroRNA changes in cerebrospinal fluid after subarachnoid hemorrhage. Stroke 48(9):2391–2398

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Lopes KP, Vinasco-Sandoval T, Vialle RA, Paschoal FM Jr, Bastos VAPA, Bor-Seng-Shu E, Teixeira MJ, Yamada ES, Pinto P, Vidal AF, Ribeiro-Dos-Santos A, Moreira F, Santos S, Paschoal EHA, Ribeiro-Dos-Santos  (2018) Global miRNA expression profile reveals novel molecular players in aneurysmal subarachnoid haemorrhage. Sci Rep 8(1):8786

    Article  PubMed  PubMed Central  Google Scholar 

  29. Pulcrano-Nicolas AS, Proust C, Clarençon F, Jacquens A, Perret C, Roux M, Shotar E, Thibord F, Puybasset L, Garnier S, Degos V, Trégouët DA (2018) Whole-blood miRNA sequencing profiling for vasospasm in patients with aneurysmal subarachnoid hemorrhage. Stroke 49(9):2220–2223

    Article  CAS  PubMed  Google Scholar 

  30. Zhao H, Li Y, Chen L, Shen C, Xiao Z, Xu R, Wang J, Luo Y (2019) HucMSCs-derived miR-206-knockdown exosomes contribute to neuroprotection in subarachnoid hemorrhage induced early brain injury by targeting BDNF. Neuroscience 417:11–23

    Article  CAS  PubMed  Google Scholar 

  31. Qin X, Akter F, Qin L, Xie Q, Liao X, Liu R, Wu X, Cheng N, Shao L, Xiong X, Liu R, Wan Q, Wu S (2019) MicroRNA-26b/PTEN signaling pathway mediates glycine-induced neuroprotection in SAH injury. Neurochem Res 44(11):2658–2669

    Article  CAS  PubMed  Google Scholar 

  32. Su XW, Chan AH, Lu G, Lin M, Sze J, Zhou JY, Poon WS, Liu Q, Zheng VZ, Wong GK (2015) Circulating microRNA 132-3p and 324-3p profiles in patients after acute aneurysmal subarachnoid hemorrhage. PLoS One 10(12):e0144724

    Article  PubMed  PubMed Central  Google Scholar 

  33. Powers CJ, Dickerson R, Zhang SW, Rink C, Roy S, Sen CK (2016) Human cerebrospinal fluid microRNA: temporal changes following subarachnoid hemorrhage. Physiol Genomics 48(5):361–366

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Ouyang Y, Li D, Wang H, Wan Z, Luo Q, Zhong Y, Yin M, Qing Z, Li Z, Bao B, Chen Z, Yin X, Zhu LQ (2019) MiR-21-5p/dual-specificity phosphatase 8 signalling mediates the anti-inflammatory effect of haem oxygenase-1 in aged intracerebral haemorrhage rats. Aging Cell 18(6):e13022

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Shang Y, Dai S, Chen X, Wen W, Liu X (2019) MicroRNA-93 regulates the neurological function, cerebral edema and neuronal apoptosis of rats with intracerebral hemorrhage through TLR4/NF-κB signaling pathway. Cell Cycle 18(22):3160–3176

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Hu L, Zhang H, Wang B, Ao Q, Shi J, He Z (2019) MicroRNA-23b alleviates neuroinflammation and brain injury in intracerebral hemorrhage by targeting inositol polyphosphate multikinase. Int Immunopharmacol 76:105887

    Article  CAS  PubMed  Google Scholar 

  37. Li HT, Wang J, Li SF, Cheng L, Tang WZ, Feng YG (2018) Upregulation of microRNA-24 causes vasospasm following subarachnoid hemorrhage by suppressing the expression of endothelial nitric oxide synthase. Mol Med Rep 18(1):1181–1187

    CAS  PubMed  Google Scholar 

  38. Sheng B, Lai NS, Yao Y, Dong J, Li ZB, Zhao XT, Liu JQ, Li XQ, Fang XG (2018) Early serum miR-1297 is an indicator of poor neurological outcome in patients with aSAH. Biosci Rep 38(6):BSR20180646

    Article  PubMed  PubMed Central  Google Scholar 

  39. Liao B, Zhou MX, Zhou FK, Luo XM, Zhong SX, Zhou YF, Qin YS, Li PP, Qin C (2019) Exosome-derived MiRNAs as biomarkers of the development and progression of intracranial aneurysms. J Atheroscler Thromb. https://doi.org/10.5551/jat.51102

  40. Fan W, Liu Y, Li C, Qu X, Zheng G, Zhang Q, Pan Z, Wang Y, Rong J (2020) microRNA-331-3p maintains the contractile type of vascular smooth muscle cells by regulating TNF-α and CD14 in intracranial aneurysm. Neuropharmacology 164:107858

    Article  PubMed  Google Scholar 

  41. Gao G, Zhang Y, Chao Y, Niu C, Fu X, Wei J (2019) miR-4735-3p regulates phenotypic modulation of vascular smooth muscle cells by targeting HIF-1-mediated autophagy in intracranial aneurysm. J Cell Biochem 120(12):19432–19441

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Biotechnology, National Institute of Technology Calicut, Calicut, India

    Rajanikant G. K. & Gokul Surendran

  2. NeuroDiderot, Inserm, Université de Paris, Paris, France

    Pierre Gressens & Cindy Bokobza

  3. Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition INSERM 1172, Lille, France

    Sreekala S. Nampoothiri

Authors
  1. Rajanikant G. K.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Pierre Gressens
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sreekala S. Nampoothiri
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gokul Surendran
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Cindy Bokobza
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

G. K., R., Gressens, P., Nampoothiri, S.S., Surendran, G., Bokobza, C. (2020). Interplay Between microRNAs and Other Cerebrovascular Diseases. In: IschemiRs: MicroRNAs in Ischemic Stroke. Springer, Singapore. https://doi.org/10.1007/978-981-15-4798-0_8

Download citation

Publish with us

Policies and ethics

Search

Navigation