Abstract
The genetically encoded biosensors, which could transform the input of specific metabolic concentrations into output of gene expression levels, have been developed by hacking the sensing and regulatory systems of the cell such as allosteric transcription factors (aTFs) and riboswitches. In this chapter, we first introduce the classification and functional mechanism of genetically encoded biosensor. Furthermore, the applications of biosensor in the development of microbial cell factories including high-throughput screening and dynamic metabolic engineering are reviewed. Finally, the future perspectives on biosensors and their applications are discussed.
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Wu, Y., Du, G., Chen, J., Liu, L. (2020). Genetically Encoded Biosensors and Their Applications in the Development of Microbial Cell Factories. In: Singh, V., Singh, A., Bhargava, P., Joshi, M., Joshi, C. (eds) Engineering of Microbial Biosynthetic Pathways. Springer, Singapore. https://doi.org/10.1007/978-981-15-2604-6_4
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