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An Overview of Non-coding RNAs and Cardiovascular System

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Non-coding RNAs in Cardiovascular Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1229))

Abstract

Cardiovascular disease management and timely diagnosis remain a major dilemma. Delineating molecular mechanisms of cardiovascular diseases is opening horizon in the field of molecular medicines and in the development of early diagnostic markers. Non-coding RNAs are the highly functional and vibrant nucleic acids and are known to be involved in the regulation of endothelial cells, vascular and smooth muscles cells, cardiac metabolism, ischemia, inflammation and many processes in cardiovascular system. This chapter is comprehensively focusing on the overview of the non-coding RNAs including their discovery, generation, classification and functional regulation. In addition, overview regarding different non-coding RNAs as long non-coding, siRNAs and miRNAs involvement in the cardiovascular diseases is also addressed. Detailed functional analysis of this vast group of highly regulatory molecules will be promising for shaping future drug discoveries.

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Acknowledgments

Higher Education Commission of Pakistan Grant to Murtaza I (6165/Federal/NRPU/R&D/HEC/2016) and the URF, QAU funds to Murtaza I.

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The authors declare no competing financial interests.

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  1. Department of Biochemistry, Signal Transduction Laboratory, Faculty of Biological Sciences, Quaid-i-Azam University Islamabad, Islamabad, Pakistan

    Iram Mushtaq, Ayesha Ishtiaq, Tahir Ali, Muhammad Ishtiaq Jan & Iram Murtaza

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  1. Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China

    Junjie Xiao

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Mushtaq, I., Ishtiaq, A., Ali, T., Jan, M.I., Murtaza, I. (2020). An Overview of Non-coding RNAs and Cardiovascular System. In: Xiao, J. (eds) Non-coding RNAs in Cardiovascular Diseases. Advances in Experimental Medicine and Biology, vol 1229. Springer, Singapore. https://doi.org/10.1007/978-981-15-1671-9_1

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