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Risk Factors for AKI Development in Acute Decompensated Heart Failure

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Acute Kidney Injury and Regenerative Medicine

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Abstract

Despite the advances in management, acute decompensated heart failure (ADHF) continues to be associated with poor clinical outcomes. Renal dysfunction, especially acute kidney injury (AKI), is one of the strongest predictors of adverse outcomes in ADHF. The association between the heart and the kidney in patients with ADHF is complex, and a complete understanding of this bidirectional interaction has not been elucidated. There are two big issues in this field. First is that many different definitions for renal dysfunction have been used conventionally. This would create different interpretations of renal failure in ADHF. Another problem is that the timing of WRF/AKI onset during hospitalization varies. To reconsider the future direction of AKI, this review focused on the current perspectives on AKI in ADHF patients.

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Acknowledgments

Funding: NJ received honoraria from Chugai Pharmaceutical and Kyowa Hakko Kirin.

Conflicts of interest: The authors have no potential conflict of interest to disclose.

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Authors and Affiliations

  1. Division of Nephrology, Toho University Ohashi Medical Center, Tokyo, Japan

    Nobuhiko Joki, Yuri Tanaka, Toshihide Hayashi & Hiroki Hase

  2. Division of Nephrology, Toho University Sakura Medical Center, Chiba, Japan

    Yasushi Ohashi

  3. Division of Nephrology, Toho University Omori Medical Center, Tokyo, Japan

    Ken Sakai

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  1. Nobuhiko Joki
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  2. Yasushi Ohashi
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  4. Toshihide Hayashi
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Editors and Affiliations

  1. Department of Endocrinology, Metabolism, and Nephrology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan

    Yoshio Terada

  2. Department of Nephrology and Laboratory Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

    Takashi Wada

  3. Department of Acute Medicine, The University of Tokyo, Tokyo, Japan

    Kent Doi

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Joki, N., Ohashi, Y., Tanaka, Y., Hayashi, T., Sakai, K., Hase, H. (2020). Risk Factors for AKI Development in Acute Decompensated Heart Failure. In: Terada, Y., Wada, T., Doi, K. (eds) Acute Kidney Injury and Regenerative Medicine . Springer, Singapore. https://doi.org/10.1007/978-981-15-1108-0_6

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