Skip to main content

Modelling the Effects of Stigma on Leprosy

  • Conference paper
  • First Online:
Mathematical Analysis and Applications in Modeling (ICMAAM 2018)

Abstract

The World Health Organization’s leprosy-elimination campaign has significantly reduced global leprosy prevalence, but approximately 214,000 new cases of leprosy are reported each year. An ancient and neglected affliction, leprosy is also one of the most heavily stigmatised diseases of all time. We developed a mathematical model to examine the effects of stigma on sustaining disease transmission, using low and high degrees of stigma, as well as in its absence. Our results show that stigma does indeed play a central role in the long-term sustainability of leprosy. We also examined sensitivity of the outcome to all parameters and showed that the effects of stigma could increase the number of infected individuals by a factor of 80. Therefore both targeted education and shifts in cultural attitudes towards leprosy will be necessary for the eventual eradication of the disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Blok, D., de Vlas, S., Fischer, E., Richardus, J.: Mathematical modelling of leprosy and its control. Adv. Parasitol. 87, 33–51 (2014)

    Article  Google Scholar 

  2. Blower, S., Dowlatabadi, H.: Sensitivity and unvertainty analysis of complex models. Int. Stat. Rev. 62, 229–243 (1994)

    Article  Google Scholar 

  3. Cross, H., Choudhary, R.: STEP: an intervention to address the issue of stigma related to leprosy in Southern Nepal. Lepr. Rev. 76, 316–324 (2005)

    Google Scholar 

  4. Dara, S., Gadde, R.: Epidemiology, prognosis, and prevention of leprosy worldwide. R. Curr. Trop. Med. Rep. (2016)

    Google Scholar 

  5. Fischer, E., Vlas, D., Meima, A., Habbema, D., Richardus, J.: Different mechanisms for heterogeneity in leprosy susceptibility can explain disease clustering within households. PLoS ONE 5 (2012)

    Article  Google Scholar 

  6. Kealey, A., Smith?, R.: Neglected tropical diseases: infection, modelling and control. J. Health Care Poor Underserved 21, 53–69 (2010)

    Google Scholar 

  7. Kumaresan, J., Maganu, E.: Socio-cultural dimensions of leprosy in North-Western Botswana. Soc. Sci. Med. 39, 537–541 (1994)

    Article  Google Scholar 

  8. Lechat, M., Misson, C., Lambert, A.: Simulation of vaccination and resistance in leprosy using an epidemiometric model. Int. J. Lepr. 53, 461–467 (1985)

    Google Scholar 

  9. Link, B.G., Phelan, J.C.: Conceptualizing stigma. Annu. Rev. Sociol. 27, 363–385 (2001)

    Article  Google Scholar 

  10. Lockwood, D., Suneetha, S.: Leprosy: too complex a disease for a simple elimination paradigm. Bull. World Health Organ. 83, 230–235 (2005)

    Google Scholar 

  11. Lustosa, A., Nogueira, L., Pedrosa, J., Teles, J., Campelo, V.: The impact of leprosy on health-related quality of life. Revista da Sociedade Brasileira de Medicina Tropical 44, 621–626 (2011)

    Article  Google Scholar 

  12. Meima, A., Gupte, M., Oortmarssen, G.V., Habbema, J.: Simlep: a simulation model for leprosy transmission and control. Int. J. Lepr. Other Mycobact. Dis. 67, 215–236 (1999)

    Google Scholar 

  13. Merle, C., Cunha, S., Rodrigues, L.: BCG vaccination and leprosy protection: review of current evidence and status of BCG in leprosy control. Expert. Rev. Vaccines 9, 209–222 (2012)

    Article  Google Scholar 

  14. Mg, W.: Stigma and the social burden of neglected tropical diseases. PLoS Negl. Trop. Dis. 2, e237 (2008)

    Article  Google Scholar 

  15. Mushuyabasa, S., Bhunu, C.: Modelling the effects of chemotheraphy and relapse on the transmission dynamics of leprosy. Math. Sci. 6, 12 (2012)

    Article  Google Scholar 

  16. Rafferty, J.: Curing the stigma of leprosy. Lepr. Rev. 76(2), 119–126 (2005)

    Google Scholar 

  17. Richardus, J., Habbema, J.: The impact of leprosy control on the transmission of M. leprae: is elimination being attained? Lepr. Rev. 78(4), 330–337 (2007)

    Google Scholar 

  18. Rodrigues, L., Lockwood, D.: Leprosy now: epidemiology, progress and research gaps. Lancet Infect. Dis. 11(6), 464–470 (2011)

    Article  Google Scholar 

  19. Sengupta, S., Banks, B., Jonas, D., Miles, M.S., Smith, G.C.: HIV interventions to reduce HIV/AIDS stigma: a systematic review. AIDS Behav. 15, 1075–1087 (2011)

    Article  Google Scholar 

  20. Smith, W., Anderson, A., Withington, S., Van Brakel, W., Croft, R., Nicholls, P., Richardus, J.: Steroid prophylaxis for prevention of nerve function impairment in leprosy: randomised placebo controlled trial (tripod 1). Br. Med. J., 328 (2004)

    Google Scholar 

  21. Suzuki, K., Akama, T., Kawashima, A., Yoshihara, A., Yotstu, R., Ishii, N.: Current status of leprosy: epidemiology, basic science and clinical perspectives. Adv. Exp. Med. Biol. 582, 22–33 (2012)

    Google Scholar 

  22. Tsutsumi, A., Izutsu, T., Islam, M.D.A., Amed, J.U., Nakahara, S., Takagi, F., Wakai, S.: Depressive status of leprosy patients in Bangladesh: association with self-perception of stigma. Lepr. Rev., 57–66 (2004)

    Google Scholar 

  23. van Brakel, W.H., Sihombing, B., Djarir, H., Beise, K., Kusumawardhani, L., Yulihane, R., Kurniasari, I., Kasim, M., Kesumaningsih, K.I., Wilder-Smith, A.: Disability in people affected by leprosy: the role of impairment, activity, social participation, stigma and discrimination. Glob. Health Action 5, 18394 (2012)

    Article  Google Scholar 

  24. Weiss, M., Ramakrishna, J., Somma, D.: Health-related stigma: rethinking concepts and interventions. Pyschology Health Med. 11(3), 277–287 (2006)

    Article  Google Scholar 

  25. World Bank: Crude birth rate for developing countries in Middle East and North Africa (2016)

    Google Scholar 

  26. Yang, L.H., Kleinman, A., Link, B.G., Phelan, J.C., Lee, S., Good, B.: Culture and stigma: adding moral experience to stigma theory. Soc. Sci. Med. 64, 1524–1535 (2007)

    Article  Google Scholar 

Download references

Acknowledgements

The authors are grateful to Alison Kealey and Nyuk Sian Chong for invaluable assistance and are also grateful to an anonymous reviewer for insightful comments that greatly improved the manuscript. RS? is supported by an NSERC Discovery Grant. For citation purposes, please note that the question mark in “Smith?” is part of the author’s name.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert Smith .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer Nature Singapore Pte Ltd.

About this paper

Check for updates. Verify currency and authenticity via CrossMark

Cite this paper

Mosher, S.G., Costris-Vas, C., Smith, R. (2020). Modelling the Effects of Stigma on Leprosy. In: Roy, P., Cao, X., Li, XZ., Das, P., Deo, S. (eds) Mathematical Analysis and Applications in Modeling. ICMAAM 2018. Springer Proceedings in Mathematics & Statistics, vol 302. Springer, Singapore. https://doi.org/10.1007/978-981-15-0422-8_5

Download citation

Publish with us

Policies and ethics