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IPN Dendrimers in Drug Delivery

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Interpenetrating Polymer Network: Biomedical Applications

Abstract

Instead of enormous development in biomedical field, the treatment of severe ailments like tuberculosis, visceral leishmaniasis, systemic fungal infections, HIV and cancer still faces noteworthy confronts like severe toxicities, resistance and patient non-compliance, etc. To overcome these problems interpenetrating polymeric nanomaterials like liposomes, nanoparticles, dendrimers, carbon nanotubes and quantum dots are continuously being explored to improve therapeutic index of available medicine as well as new drug entity. This review exhaustively summarizes the dendrimer-mediated advancements in the drug delivery as well as possible avenues where dendrimers could be exploited to improve the therapeutic effectiveness of currently available treatment strategies. Dendrimers are a new class of interpenetrating polymer network (IPN) with unique properties like well-defined size and structure, versatility, water solubility, multivalency and internal hydrophobic cavities, which rendered these nanostructures an emerging carrier in biomedical and drug delivery applications. Classically, these well-defined nano-architectures have been explored as nanoscaffolds and nano-containers to conjugate and deliver drugs, genes, oligonucleopeptides, imaging agents, siRNA, aptamers, etc. In spite of tremendous research efforts over nearly three decades, the stakeholders are confronted with certain fundamental issues related to dendrimer applications. In this review, we propose to dwell upon the unexplored facets of dendrimer research with possible applications in drug delivery.

IPN: Interpenetrating polymer network

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Authors and Affiliations

  1. Department of Pharmaceutics, Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi, India

    Keerti Jain & Vineet Kumar Jain

  2. Sentiss Pharma Pvt. Ltd, Gurgaon, India

    Neelesh Kumar Mehra

  3. School of Pharmaceutical Sciences, Rajiv Gandhi Technical University, Bhopal, India

    Narendra Kumar Jain

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  1. Keerti Jain
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  2. Neelesh Kumar Mehra
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  3. Vineet Kumar Jain
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  4. Narendra Kumar Jain
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  1. Department of Pharmaceutics, Gupta College of Technological Sciences, Asansol, West Bengal, India, Department of Health and Family Welfare, Directorate of Health Services, Kolkata, India

    Sougata Jana

  2. Department of Chemistry, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh, India

    Subrata Jana

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Jain, K., Mehra, N.K., Jain, V.K., Jain, N.K. (2020). IPN Dendrimers in Drug Delivery. In: Jana, S., Jana, S. (eds) Interpenetrating Polymer Network: Biomedical Applications. Springer, Singapore. https://doi.org/10.1007/978-981-15-0283-5_6

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