Skip to main content
SpringerLink
Log in

Secondary Metabolites of Mushrooms: A Potential Source for Anticancer Therapeutics with Translational Opportunities

  • Chapter
  • First Online:
Advancing Frontiers in Mycology & Mycotechnology

Abstract

Across the globe cancer is emerging as an overriding source of death raising enduring consequences all through the life period of patients. Chemotherapeutic drugs adopted for cancer therapy have grievous after-effects, and growth of resistance is a major downside for these agents. For decades natural products and medicine have been intimately connected through the usage of conventional medicines. Mushrooms own substantial antiquity of use in conventional medicine with no or minimal side effects. Mushrooms are considered as superfoods due to the presence of bioactive compounds and origin of medical drug and nutraceutical development for enhancing longevity of people. Recently there is an elevated interest found in people for the secondary metabolites of higher fungi in order to explore novel medical substance or lead compounds for cancer treatment. A number of novel fungal metabolites have been extracted from higher fungi which are likely to provide drugs with chemopreventive property. The researches involved the drug discovery from medicinal fungi mainly implicating multifaceted approach. Most of the isolated compounds have exhibited prominent in vitro cytotoxic effects in cancer cell lines from human tissue, and specifically selected compounds were used for in vivo experiments. This chapter cautiously deals with the review of low-molecular-weight compounds obtained from higher fungi with anticancer potential identified so far. In the near future, among these novel compounds many are presumed to enter human clinical trials.

Authors Sudeshna Nandi, Rimpa Sikder have been equally contrbuted to this chapter.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Akihisa T, Mizushina Y, Ukiya M, Oshikubo M, Kondo S, Kimura Y, Suzuki T, Tai T (2004) Dehydrotrametenonic acid and dehydroeburiconic acid from Poria cocos and their inhibitory effects on eukaryotic DNA polymerase alpha and beta. Biosci Biotechnol Biochem 68:448–450

    Article  CAS  PubMed  Google Scholar 

  • Akihisa T, Nakamura Y, Tagata M, Tokuda H, Yasukawa K, Uchiyama E, Suzuki T, Kimura Y (2007) Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum. Chem Biodivers 4:224–231

    Article  CAS  PubMed  Google Scholar 

  • Arora R, Yates C, Gary BD, McClellan S, Tan M, Xi Y, Reed E, Piazza GA, Owen LB, Dean-Colomb W (2014) Panepoxydone targets NF-kB and FOXM1 to inhibit proliferation, induce apoptosis and reverse epithelial to mesenchymal transition in breast cancer. PLoS One 9(6):e98370

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Arpha K, Phosri C, Suwannasai N, Mongkolthanaruk W, Sodngam S (2012) Astraodoric acids A-D: new lanostane triterpenes from edible mushroom Astraeus odoratus and their Mycobacterium tuberculosis H37Ra and cytotoxic activity. J Agric Food Chem 60:9834–9841

    Article  CAS  PubMed  Google Scholar 

  • Awadh Ali NA, Mothana RA, Lesnau A, Pilgrim H, Lindequist U (2003) Antiviral activity of Inonotus hispidus. Fitoterapia 74:483–485

    Article  CAS  PubMed  Google Scholar 

  • Azeem U, Dhingra GS, Shri R (2018) Pharmacological potential of wood inhabiting fungi of genus Phellinus Quél.: an overview. J Pharmacogn Phytochem 7:1161–1171

    CAS  Google Scholar 

  • Baby S, Johnson AJ, Balaji G (2015) Secondary metabolites from Ganoderma. Phytochemistry 114:66–101

    Article  CAS  PubMed  Google Scholar 

  • Batra P, Sharma AK, Khajuria R (2013) Probing Lingzhi or Reishi medicinal mushroom Ganoderma lucidum (higher Basidiomycetes): a bitter mushroom with amazing health benefits. Int J Med Mushrooms 15:127–143

    Article  CAS  PubMed  Google Scholar 

  • Berns H, Humar R, Hengerer B, Kiefer FN, Battegay EJ (2000) RACK1 is up-regulated in angiogenesis and human carcinomas. FASEB J 14:2549–2558

    Article  CAS  PubMed  Google Scholar 

  • Besl H, Hoefle G, Jendrny B, Jagers E, Steglich W (1977) Pilzpigmente, XXXI. Farnesylphenole aus Albatrellus-Arten (Basidiomycetes). Chem Ber 110:3770–3776

    Article  CAS  Google Scholar 

  • Bhattarai G, Lee YH, Lee NH, Lee IK, Yun BS, Hwang PH, Yi HK (2012) Fomitoside-K from Fomitopsis nigra induces apoptosis of human oral squamous cell carcinomas (YD-10B) via mitochondrial signaling pathway. Biol Pharm Bull 35:1711–1719

    Article  CAS  PubMed  Google Scholar 

  • Bok JW, Lermer L, Chilton J, Klingeman HG, Towers GH (1999) Antitumor sterols from the mycelia of Cordyceps sinensis. Phytochemistry 51:891–898

    Article  CAS  PubMed  Google Scholar 

  • Brakhage AA (2013) Regulation of fungal secondary metabolism. Nat Rev Microbiol 11:21–32

    Article  CAS  PubMed  Google Scholar 

  • Chang KL, Kung ML, Chow NH, Su SJ (2004) Genistein arrests hepatoma cells at G2/M phase: involvement of ATM activation and upregulation of p21waf1/cip1 and Wee1. Biochem Pharmacol 67:717–726

    Article  CAS  PubMed  Google Scholar 

  • Chen NH, Zhong JJ (2011) p53 is important for the anti-invasion of ganoderic acid T in human carcinoma cells. Phytomedicine 18:719–725

    Article  CAS  PubMed  Google Scholar 

  • Chen W, He FY, Li YQ (2006) The apoptosis effect of hispolon from Phellinus linteus (Berkeley & Curtis) Teng on human epidermoid KB cells. J Ethnopharmacol 105:280–285

    Article  CAS  PubMed  Google Scholar 

  • Chen NH, Liu JW, Zhong JJ (2008a) Ganoderic acid me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression. J Pharmacol Sci 108:–212, 216

    Article  CAS  PubMed  Google Scholar 

  • Chen W, Zhao Z, Li L, Wu B, Chen SF, Zhou H, Wang Y, Li YQ (2008b) Hispolon induces apoptosis in human gastric cancer cells through a ROS-mediated mitochondrial pathway. Free Radic Biol Med 45:60–72

    Article  PubMed  CAS  Google Scholar 

  • Chen Y, Chen YC, Lin YT, Huang SH, Wang SM (2010a) Cordycepin induces apoptosis of CGTH W-2 thyroid carcinoma cells through the calcium-calpain-caspase 7-PARP pathway. J Agric Food Chem 58:11645–11652

    Article  CAS  PubMed  Google Scholar 

  • Chen NH, Liu JW, Zhong JJ (2010b) Ganoderic acid T inhibits tumor invasion in vitro and in vivo through inhibition of MMP expression. Pharmacol Rep 62:150–163

    Article  CAS  PubMed  Google Scholar 

  • Chen YC, Chang HY, Deng JS, Chen JJ, Huang SS, Lin IH, Kuo WL, Chao W, Huang GJ (2013) Hispolon from Phellinus linteus induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells. Am J Chin Med 41:1439–1457

    Article  CAS  PubMed  Google Scholar 

  • Chen Y, Peng GF, Han XZ, Wang W, Zhang GQ, Li X (2015) Apoptosis prediction via inhibition of AKT signaling pathway by neogrifolin. Int J Clin Exp Pathol 8:1154–1164

    CAS  PubMed  PubMed Central  Google Scholar 

  • Chen HP, Zhao ZZ, Li ZH, Huang Y, Zhang SB, Tang Y, Yao JN, Chen L, Isaka M, Feng T, Liu JK (2018) Anti-proliferative and anti-inflammatory lanostane triterpenoids from the polish tdible mushroom Macrolepiota procera. J Agric Food Chem 66:3146–3154

    Article  CAS  PubMed  Google Scholar 

  • Cheng CR, Yue QX, Wu ZY, Song XY, Tao SJ, Wu XH, Xu PP, Liu X, Guan SH, Guo DA (2010) Cytotoxic triterpenoids from Ganoderma lucidum. Phytochemistry 71:1579–1585

    Article  CAS  PubMed  Google Scholar 

  • China PR (1986) Dictionary of traditional Chinese medicine. Jiangsu New Medical College (eds). Shanghai Scientific, Shanghai, pp 2191–2193

    Google Scholar 

  • Choi YH, Lee WH, Park KY, Zhang L (2000) p53-independent induction of p21 (WAF1/CIP1), reduction of cyclin B1 and G2/M arrest by the isoflavone genistein in human prostate carcinoma cells. Jpn J Cancer Res 91:164–173

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • De Silva DD, Rapior S, Fons F, Bahkali AH, Hyde KD (2012) Medicinal mushrooms in supportive cancer therapies: an approach to anticancer effects and putative mechanisms of action- a review. Fungal Divers 55:1–35

    Article  Google Scholar 

  • De Silva DD, Rapior S, Sudarman E, Stadler M, Xu J, Alias SA, Hyde KD (2013) Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry. Fungal Divers 62:1–40

    Article  Google Scholar 

  • Debbab A, Aly AH, Proksch P (2011) Bioactive secondary metabolites from endophytes and associated marine derived fungi. Fungal Divers 49:1–12

    Article  Google Scholar 

  • Debbab A, Aly AH, Proksch P (2012) Endophytes and associated marine derived fungi-ecological and chemical perspectives. Fungal Divers 57:45–83

    Article  Google Scholar 

  • Dias DA, Urban S, Roessner U (2012) A historical overview of natural products in drug discovery. Meta 2:303–336

    CAS  Google Scholar 

  • Didukh M, Wasser SP, Nevo E (2004) Impact of the family Agaricaceae (Fr.) Cohn on nutrition and medicine, Volz A (ed). ARG Ganter Verlag KG, Konigstein, Germany

    Google Scholar 

  • Ding JH, Li ZH, Feng T, Liu JK (2018) A new cadinane sesquiterpenoid from cultures of the basidiomycete Panus conchatus. Nat Prod Res 32:2333–2337

    Article  CAS  PubMed  Google Scholar 

  • Du YC, Wu TY, Chang FR, Lin WY, Hsu YM, Cheng FT, Lu CY, Yen MH, Tsui YT, Chen HL, Hou MF, Lu MC, Wu YC (2012) Chemical profiling of the cytotoxic triterpenoid-concentrating fraction and characterization of ergostane stereo-isomer ingredients from Antrodia camphorata. J Pharm Biomed Anal 58:182–192

    Article  CAS  PubMed  Google Scholar 

  • El Bohi KM, Sabik L, Muzandu K, Shaban Z, Soliman M, Ishizuka M, Kazusaka A, Fujita S (2005) Antigenotoxic effect of Pleurotus cornucopiae extracts on the mutagenesis of Salmonella typhimurium TA98 elicited by benzo[a]pyrene and oxidative DNA lesions in V79 hamster lung cells. Jpn J Vet Res 52:163–172

    PubMed  Google Scholar 

  • Erkel G, Anke T, Sterner O (1996) Inhibition of NF-kappa B activation by panepoxydone. Biochem Biophys Res Commun 226:214–221

    Article  CAS  PubMed  Google Scholar 

  • Erkel G, Wisser G, Anke T (2007) Influence of the fungal NF-kB inhibitor panepoxydone on inflammatory gene expression in MonoMac6 cells. Int Immunopharmacol 7:612–624

    Article  CAS  PubMed  Google Scholar 

  • Evidente A, Kornienko A, Cimmino A, Andolfi A, Lefranc F, Mathieud V, Kiss R (2014) Fungal metabolites with anticancer activity. Nat Prod Rep 31:617–627

    Article  CAS  PubMed  Google Scholar 

  • Ferreira ICFR, Vaz JA, Vasconcelos MH, Martins A (2010) Compounds from wild mushrooms with antitumor potential. Anti Cancer Agents Med Chem 10:424–436

    Article  CAS  Google Scholar 

  • Figueiredo L, Regis WCB (2017) Medicinal mushrooms in adjuvant cancer therapies: an approach to anticancer effects and presumed mechanisms of action. Figueiredo and Régis Nutrire 42:28

    Article  CAS  Google Scholar 

  • Friedman M (2015) Chemistry, nutrition, and health-promoting properties of (Lion’s mane) mushroom fruiting bodies and mycelia and their bioactive compounds. J Agr Food Chem 63(32):7108–7123

    Google Scholar 

  • Gan KH, Kuo SH, Lin C (1998) Steroidal constituents of Ganoderma applanatum and Ganoderma neo-japonicum. J Nat Prod 61:1421–1422

    Google Scholar 

  • Gao JJ, Min BS, Ahn EM, Nakamura N, Lee HK, Hattori M (2002) New triterpene aldehydes, lucialdehydes A-C, from Ganoderma lucidum and their cytotoxicity against murine and human tumor cells. Chem Pharmacol Bull 50:837–840

    Article  CAS  Google Scholar 

  • Gao JJ, Hirakawa A, Min BS, Nakamura N, Hattori M (2006) In vivo antitumor effects of bitter principles from the antlered form of fruiting bodies of Ganoderma lucidum. J Nat Med 60:42–48

    Article  CAS  Google Scholar 

  • Golak IS, KaÅ‚użewicz A, Spiżewski T, Siwulski M, Sobieralski K (2018) Bioactive compounds and medicinal properties of oyster mushrooms (Pleurotus sp.). A review Folia Hort 30(2)

    Google Scholar 

  • Gonindard C, Bergonzi C, Denier C, Sergheraert C, Klaebe A, Chavant L, Hollande E (1997) Synthetic hispidin, a PKC inhibitor, is more cytotoxic toward cancer cells than normal cells in vitro. Cell Biol Toxicol 13:141–153

    Article  CAS  PubMed  Google Scholar 

  • Handa N, Yamada T, Tanaka R (2010) An unusual lanostane-type triterpenoid, spiroinonotsuoxodiol, and other triterpenoids from Inonotus obliquus. Phytochemistry 71:1774–1779

    Article  CAS  PubMed  Google Scholar 

  • Haranaka K, Satomi N, Sakurai A, Yasukawa K, Takido M (1987) Antitumor activities of Zyuzen-taiho-to and Cinnamomi cortex. J Med Pharmaceut Soc Wakan-Yaku 4:49–58

    Google Scholar 

  • Harvey AL (2008) Natural products in drug discovery. Drug Discov Today 13:894–901

    Article  CAS  PubMed  Google Scholar 

  • Hirata Y, Nakanishi K (1950) Grifolin, an antibiotic from a basidiomycete. J Biol Chem 184:135–143

    CAS  PubMed  Google Scholar 

  • Holliday J, Cleaver M (2008) Medicinal value of the cterpillar fungi species of the genus Cordyceps (Fr.) link (ascomycetes)-a review. Int J Med Mushrooms 10:219–234

    Article  CAS  Google Scholar 

  • Hsu CL, Yu YS, Yen GC (2008) Lucidenic acid B induces apoptosis in human leukemia cells via a mitochondria-mediated pathway. J Agric Food Chem 56:3973–3980

    Article  CAS  PubMed  Google Scholar 

  • Huang GJ, Deng JS, Huang SS, Hu ML (2011) Hispolon induces apoptosis and cell cycle arrest of human hepatocellular carcinoma Hep3B cells by modulating ERK phosphorylation. J Agric Food Chem 59:7104–7113

    Article  CAS  PubMed  Google Scholar 

  • Huang HC, Liaw CC, Yang HL, Hseu YC, Kuo HT, Tsai YC, Chien SC, Amagaya S, Chen YC, Kuo YH (2012) Lanostane triterpenoids and sterols from Antrodia camphorata. Phytochemistry 84:177–183

    Article  CAS  PubMed  Google Scholar 

  • Isaka M, Palasarn S, Srikitikulchai P, Vichai V, Komwijit S (2016) Astraeusins AeL, lanostane triterpenoids from the edible mushroom Astraeus odoratus. Tetrahedron 72:3288–3295

    Article  CAS  Google Scholar 

  • Ito Y, Arita M, Adachi K, Shibata T, Sawai H, Ohno M (1981) Chirally selective synthesis of sugar moiety of nucleosides by chemicoenzymatic approach: L- and D-riboses, showdomycin, and cordycepin. Nucleic Acids Symp Ser 10:45–48

    CAS  Google Scholar 

  • Ivanova TS, Krupodorova TA, Barshteyn VY, Artamonova AB, Shlyakhovenko VA (2014) Anticancer substances of mushroom origin. Exp Oncol 36:58–66

    CAS  PubMed  Google Scholar 

  • Jeong JW, Jin CY, Park C, Hong SH, Kim GY, Jeong YK, Lee JD, Yoo YH, Choi YH (2011) Induction of apoptosis by cordycepin via reactive oxygen species generation in human leukemia cells. Toxicol In Vitro 25:817–824

    Article  CAS  PubMed  Google Scholar 

  • Jiang J, Grieb B, Thyagarajan A, Sliva D (2008) Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-κB signaling. Int J Mol Med 21:577–584

    CAS  PubMed  Google Scholar 

  • Jiang J, Jedinak A, Sliva D (2011) Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA. Biochem Biophys Res Commun 415:325–329

    Article  CAS  PubMed  Google Scholar 

  • Jin S, Pang RP, Shen JN, Huang G, Wang J, Zhou JG (2007) Grifolin induces apoptosis via inhibition of PI3K/AKT signaling pathway in human osteosarcoma cells. Apoptosis 12:1317–1326

    Article  CAS  PubMed  Google Scholar 

  • Johnson BM, Doonan BP, Radwan FF, Haque A (2010) Ganoderic acid DM: an alternative agent for the treatment of advanced prostate cancer. Open Prostate Cancer J 3:78–85

    Article  CAS  Google Scholar 

  • Joseph TP, Chanda W, Padhiar AA, Batool S, LiQun S, Zhong M, Huang M (2018) A preclinical evaluation of the antitumor activities of edible and medicinal mushrooms: a molecular insight. Integr Cancer Ther 17:200–209

    Article  CAS  PubMed  Google Scholar 

  • Kadomatsu M, Nakajima S, Kato H, Gu L, Chi Y, Yao J, Kitamura M (2012) Cordycepin as a sensitizer to tumour necrosis factor (TNF)-α-induced apoptosis through eukaryotic translation initiation factor 2α (eIF2α)- and mammalian target of rapamycin complex 1 (mTORC1)-mediated inhibition of nuclear factor (NF)-κB. Clin Exp Immunol 168:325–332

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kanokmedhakul S, Lekphrom R, Kanomedhakul K, Hahnvajanawong C, Bua-art S, Saksirirat W, Prabpai S, Kongsaeree P (2012) Cytotoxic sesquiterpenes from luminescent mushroom Neonothopanus nambi. Tetrahedron 68:8261–8266

    Article  CAS  Google Scholar 

  • Kawagishi H, Li H, Tanno O, Inoue S, Ikeda S, Ohnishi-Kameyama M, Nagata T (1997) A lanostane-type triterpene from a mushroom Daedalea dickinsii. Phytochemistry 46:959–961

    Article  Google Scholar 

  • Kellof GJ, Sigman CC (2000) Intervention and chemoprevention of cancer. CCS Associates, Mountain View

    Google Scholar 

  • Kikuchi T, Uchiyama E, Ukiya M, Tabata K, Kimura Y, Suzuki T, Akihisa T (2011) Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos. J Nat Prod 74:137–144

    Article  CAS  PubMed  Google Scholar 

  • Kim H, Hall P, Smith M, Kirk M, Prasain JK, Barnes S, Grubbs C (2004) Chemoprevention by grape seed extract and Genistein in carcinogen- induced mammary cancer in rats is diet dependent. J Nutr 134:3445–3452

    Article  Google Scholar 

  • Kim DS, Jeong HJ, Bhat KP, Park SY, Kang SH, Yoo EH, Lee M, Lee HW, Krueger RJ (2000) Aromatse and sulfatase inhibitors from Lepiota americana. Planta Med 66:78–79

    Article  Google Scholar 

  • Kim YJ, Park J, Min BS, Shim SH (2011) Chemical constituents from the sclerotia of Inonotus obliquus. J Korean Soc Appl Biol Chem 54:287–294

    CAS  Google Scholar 

  • Kimura Y, Taniguchi M, Baba K (2002) Antitumor and antimetastatic effects on liver of triterpenoid fractions of Ganoderma lucidum: mechanism of action and isolation of an active substance. Anticancer Res 22:3309–3318

    CAS  PubMed  Google Scholar 

  • Kinge TR, Mih AM (2011) Secondary metabolites of oil palm isolates of Ganoderma zonatum Murill. From Cameroon and their cytotoxicity against five human tumour cell lines. Afr J Biotechnol 10:8440–8447

    Article  CAS  Google Scholar 

  • Kobori M, Yoshida M, Ohnishi-Kameyama M, Takei T, Shinmoto H (2006) 5alpha, 8alpha-epidioxy-22E-ergosta-6,9(11),22-trien-3betaol from an edible mushroom suppresses growth of HL60 leukemia and HT29 colon adenocarcinoma cells. Biol Pharm Bull 29:755–759

    Article  CAS  PubMed  Google Scholar 

  • Kozlovskii AG, Zhelifonova VP, Antipova TV (2013) Fungi of the genus Penicillium as producers of physiologically active compounds (review). Appl Biochem Microb 49:1–10

    Article  CAS  Google Scholar 

  • Kubo K, Aoki H, Naba N (1994) Anti-diabetic activities present in the fruit body of Grifola frondosa (maitake). Biol pharm bull. 17: 1106-1110.Lee IK, Jung JY, Yeom JH, Ki DW, Lee MS, yeo WH & Yun BS (2012). Fomitoside K, a new lanostane triterpene glycoside from the fruiting body of Fomitopsis nigra. Mycobiology 40:76–78

    Google Scholar 

  • Lee WY, Park Y, Ahn JK, Park SY, Lee HJ (2005) Cytotoxic activity of ergosta-4,6, 8(14),22-tetraen-3-one from the sclerotia of Polyporus umbellatus. Bull Kor Chem Soc 26:1464–1466

    Article  CAS  Google Scholar 

  • Lee SJ, Moon GS, Jung KH, Kim WJ, Moon SK (2010) C-Jun N-terminal kinase 1 is required for cordycepin-mediated induction of G2/M cell-cycle arrest via p21WAF1 expression in human colon cancer cells. Food Chem Toxicol 48:277–283

    Article  PubMed  CAS  Google Scholar 

  • Lee HJ, Burger P, Vogel M, Friese K, Bruning A (2012) The nucleoside antagonist cordycepin causes DNA double strand breaks in breast cancer cells. Investig New Drugs 30:1917–1925

    Article  CAS  Google Scholar 

  • Lee HH, Jeong JW, Lee JH, Kim GY, CHEONG J, Jeong YK, Yoo YH, Choi YH (2013a) Cordycepin increases sensitivity of Hep3B human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by inactivating the JNK signaling pathway. Oncol Rep 30:1257–1264

    Article  CAS  PubMed  Google Scholar 

  • Lee HH, Park C, Jeong JW, Kim MJ, Seo MJ, Kang BW, Park JU, Kim GY, Choi BT, Choi YH, Jeong YK (2013b) Apoptosis induction of human prostate carcinoma cells by cordycepin through reactive oxygen species-mediated mitochondrial death pathway. Int J Oncol 42:1036–1044

    Article  CAS  PubMed  Google Scholar 

  • Levin RM, Juan YS, Schuler C, Leggett RE, Lin AD (2012) Medicinal properties of Antrodia Camphorata - a review. Curr Top Nutraceutical Res 10:53–60

    Google Scholar 

  • Li Y, Mi C (2003) Proliferation inhibition and apoptosis onset in human ovarian carcinoma cell line SKOV3 induced by genistein. Ai Zheng 22:586–591

    CAS  PubMed  Google Scholar 

  • Li CH, Chen PY, Chang UM, Kan LS, Fang WH, Tsai KS, Lin SB (2005) Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases and induces apoptosis of cancer cells. Life Sci 77:252–265

    Article  CAS  PubMed  Google Scholar 

  • Li F, Wang Y, Wang X, Li J, Cui H, Niu M (2012) Ganoderic acids suppress growth and angiogenesis by modulating the Nf-kappab signaling pathway in breast cancer cells. Int J Clin Pharmacol Ther 50:712–721

    Article  CAS  PubMed  Google Scholar 

  • Li YB, Liu RM, Zhong JJ (2013) A new ganoderic acid from Ganoderma lucidum mycelia and its stability. Fitoterapia 84:115–122

    Article  CAS  PubMed  Google Scholar 

  • Li F, Zhao C, Wang L (2014) Molecular-targeted agents combination therapy for cancer: developments and potentials. Int J Cancer 134:1257–1269

    Article  CAS  PubMed  Google Scholar 

  • Li X, Wu Q, Xie Y, Ding Y, Du WW, Sdiri M, Yang BB (2015) Ergosterol purified from medicinal mushroom Amauroderma rude inhibits cancer growth in vitro and in vivo by up-regulating multiple tumor suppressors. Oncotarget 6:17832–17846

    Google Scholar 

  • Liao Z, Cox JD, Komaki R (2007) Radiochemotherapy of esophageal cancer. J Thorac Oncol 2:553–568

    Article  PubMed  Google Scholar 

  • Liu RM, Zhong JJ (2010) Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. Phytomedicine 18:349–355

    Article  PubMed  CAS  Google Scholar 

  • Liu J, Shiono J, Shimizu K, Kukita A, Kukita T, Kondo R (2009) Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor. Bioorg Med Chem Lett 19:2154–2157

    Article  CAS  PubMed  Google Scholar 

  • Liu RM, Li YB, Zhong JJ (2012a) Cytotoxic and pro-apoptotic effects of novel ganoderic acid derivatives on human cervical cancer cells in vitro. Eur J Pharmacol 68:23–33

    Article  CAS  Google Scholar 

  • Liu RM, Li YB, Zhong JJ (2012b) Ganoderic acid Mk from Ganoderma lucidum mycelia in cervical cancer HeLa cells. Lat Am J Pharm 31:43–50

    Google Scholar 

  • Liu J, Shimizu K, Tanaka A, ShinobuW OK, Nakamura T, Kondo R (2012c) Target proteins of ganoderic acid DM provides clues to various pharmacological mechanisms. Sci Rep 2:905

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lu TL, Huang GJ, Lu TJ, Wu JB, Wu CH, Yang TC, Iizuka A, Chen YF (2009) Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells. Food Chem Toxicol 47:2013–2021

    Article  CAS  PubMed  Google Scholar 

  • Lung MY, Hsieh CW (2011) Antioxidant property and production of exopolysaccharide from Armillaria mellea in submerged cultures: effect of culture aeration rate. Eng Life Sci 11:482–490

    Article  CAS  Google Scholar 

  • Manasseh AT, Godwin JTA, Ubleni EE, Borisde OO (2012) Phytochemical properties of Ganoderma applanatum as potential agents in the application of nanotechnology in modern day medical practice. Asian Pac J Trop Biomed 2:580–583

    Article  Google Scholar 

  • Mcmorris TC, Kelner MJ, Wang W, Yu J, Estes LA, Taetle R (1996) (Hydroxymethyl) acylfulvene: an illudin derivative with superior antitumor properties. J Nat Prod 59:896–899

    Article  CAS  PubMed  Google Scholar 

  • McMorris TC, Yu J, Lira R, Dawe R, MacDonald JR, Waters SJ, Estes LA, Kelner MJ (2001) Structure-activity of antitumor agent irofulven (hydroxymethylacylfulvene) and analogues. J Org Chem 66:6158–6163

    Article  CAS  PubMed  Google Scholar 

  • Mizuno T (1999a) Bioactive substances in Hericium erinaceus (bull.:Fr.) Pers. (Yamabushitake) and its medicinal utilization. Int J Med Mushrooms 1:105–119

    Article  CAS  Google Scholar 

  • Mizuno T (1999b) Extraction and development of antitumor-active polysaccharides from medicinal mushrooms in Japan. Int J Med Mushrooms 1:9–29

    Article  CAS  Google Scholar 

  • Mizuno T, Zhuang C (1995) Maitake, Grifola frondosa: pharmacological effects. Food Rev Int 11:135–149

    Article  CAS  Google Scholar 

  • Mizushina Y, Takahashi N, Hanashima L, Koshino H, Esumi Y, Uzawa J, Sugawara F, Sakaguchi K (1997) Lucidenic acid O and lactone, new terpene inhibitors of eukaryotic DNA polymerases from a basidiomycete Ganoderma lucidum. Bioorg Med Chem 7:2047–2052

    Article  Google Scholar 

  • Mizushina Y, Iida A, Ohta K, Sugawara F, Sakaguchi K (2000) Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase. Biochem J 350:757–763

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mizushina Y, Akihisa T, Ukiya M, Murakami C, Kuriyama I, Xu X, Yoshida H, Sakaguchi K (2004) A novel DNA topoisomerase inhibitor: dehydroebriconic acid, one of the lanostane-type triterpene acids from Poria cocos. Cancer Sci 95:354–360

    Article  CAS  PubMed  Google Scholar 

  • Moradali MF, Mostafavi H, Ghods S, Hedjaroude GA (2007) Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi). Int Immunopharmacol 7:701–724

    Article  CAS  PubMed  Google Scholar 

  • Nakata T, Yamada T, Taji S, Ohishi H, Wada S, Tokuda H, Sakuma K, Tanaka R (2007) Structure determination of inonotsuoxides a and B and in vivo antitumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem 15:257–264

    Article  CAS  PubMed  Google Scholar 

  • Nomura M, Takahashi T, Uesugi A, Tanaka R, Kobayashi S (2008) Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis. Anticancer Res 28:2691–2696

    CAS  PubMed  Google Scholar 

  • Nonaka Y, Ishibashi H, Nakai M, Shibata H, Kiso Y, Abe S (2008) Effects of the antlered form of Ganoderma lucidum on tumor growth and metastasis in cyclophosphamide-treated mice. Biosci Biotechnol Biochem 72:1399–1408

    Article  CAS  PubMed  Google Scholar 

  • Ohsawa T, Yukawa M, Takao C, Murayama M, Bando H (1992) Studies on constituents of fruit body of Polyporus umbellatus and their cytotoxic activity. Chem Pharm Bull 40:143–147

    Article  CAS  Google Scholar 

  • Panda AK, Swain KC (2011) Traditional uses and medicinal potential of Cordyceps sinensis of Sikkim. J Ayurveda Integr Med 2:9–13

    Article  PubMed  PubMed Central  Google Scholar 

  • Park HG, Shim YY, Choi SO, Park WM (2009) New method development for nanoparticle extraction of water-soluble β-(1–3)-D-glucan from edible mushrooms, Sparassis crispa and Phellinus linteus. J Agric Food Chem 57:2147–2154

    Article  CAS  PubMed  Google Scholar 

  • Paterson RRM (2001) Ganoderma- a therapeutic funfal biofactor. Phytochemistry 67:1985–2001

    Article  CAS  Google Scholar 

  • Paterson RRM (2006) Ganoderma - a therapeutic fungal biofactory. Phytochemistry 67:1985–2001

    Article  CAS  PubMed  Google Scholar 

  • Peng X, Liu J, Xia J, Wang C, Li X, Deng Y, Bao N, Zhang Z, Qiu M (2015) Lanostane triterpenoids from Ganoderma hainanense J. D. Zhao. Phytochemistry 114:137–145

    Article  CAS  PubMed  Google Scholar 

  • Petrova RD, Reznick AZ, Wasser SP, Denchev CM, Nevo E, Mahajna J (2008) Fungal metabolites modulating NF-κB activity: an approach to cancer therapy and chemoprevention (review). Oncol Rep 19:299–308

    CAS  PubMed  Google Scholar 

  • Pillai TG, Nair CKK, Janardhanan KK (2010) Enhancement of repair of radiation induced DNA strand breaks in human cells by Ganoderma mushroom polysaccharides. Food Chem 19:1040–1043

    Article  CAS  Google Scholar 

  • PleszczyÅ„ska M, Lemieszek MK, Siwulski M, Wiater A, Rzeski W, Szczodrak J (2017) Fomitopsis betulina (formerly Piptoporus betulinus): the Iceman’s polypore fungus with modern biotechnological potential. World J Microbiol Biotechnol 33:83

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Popovic V, Zivkovic J, Davidovic S, Stevanovic M, Stojkovic D (2013) Mycotherapy of Cancer: an update on cytotoxic and antitumor activities of mushrooms, bioactive principles and molecular mechanisms of their action. Curr Top Med Chem 13:2791–2806

    Article  CAS  PubMed  Google Scholar 

  • Poucheret P, Fons F, Rapior S (2006) Biological and pharmacological activity of higher fungi: 20-year retrospective analysis. Mycologie 27:311–333

    Google Scholar 

  • Quang DN, Hashimoto T, Asakawa Y (2006) Inedible mushrooms: a good source of biologically active substances. Chem Rec 6:79–99

    Article  CAS  PubMed  Google Scholar 

  • Rao A, Coan A, Welsh JE, Barclay WW, Koumenis C, Cramer SD (2004) Vitamin D receptor and p21/WAF1 are targets of genistein and 1,25-dihydroxyvitamin D3 in human prostate cancer cells. Cancer Res 64:2143–2147

    Article  CAS  PubMed  Google Scholar 

  • Rao YK, Fang SH, Wu WS, Tzeng YM (2010) Constituents isolated from Cordyceps militaris suppress enhanced inflammatory mediator’s production and human cancer cell proliferation. J Ethnopharmacol 131:363–367

    Article  CAS  PubMed  Google Scholar 

  • Sanodiya BS, Thakur GS, Baghel RK, Prasad GBKS, Bisen PS (2009) Ganoderma lucidum: A Potent Pharmacological Macrofungus. Curr Pharm Biotechnol 10:717–742

    Article  CAS  PubMed  Google Scholar 

  • Sharma JR, Das K, Mishra D (2013) The genus Inonotus and its related species in India. Mycosphere 4:809–818

    Article  Google Scholar 

  • Shervington A, Lu C (2008) Expression of multidrug resistance genes in normal and cancer stem cells. Cancer Investig 26:535–542

    Article  CAS  Google Scholar 

  • Silva S, Martins S, Karmali A, Rosa E (2012) Production, purification and characterisation of polysaccharides from Pleurotus ostreatus with antitumour activity. J Sci Food Agric 92:1826–1832

    Article  CAS  PubMed  Google Scholar 

  • Sporn MB, Suh N (2002) Chemoprevention of cancer. Carcinogenesis 21:524–530

    Google Scholar 

  • Suarez-Arroyo IJ, Loperena-Alvarez Y, Rosario-Acevedo R, Martínez-Montemayor MM (2017) Ganoderma spp.: a promising adjuvant treatment for breast cancer – a review. Molecules 4:15:1–23

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Sun Y, Zhao Z, Feng Q, Xu Q, Lu L, Liu JK, Zhang L, Wu B, Li YQ (2013) Unusual spirodecane sesquiterpenes and a fumagillol analogue from Cordyceps ophioglossoides. Helv Chim Acta 96:76–84

    Article  CAS  Google Scholar 

  • Takaku T, Kimura Y, Okuda H (2001) Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action. J Nutr 131:1409–1413

    Article  CAS  PubMed  Google Scholar 

  • Tan WC, Kuppusamy UR, Phan CW, Tan YS, Raman J, Anuar AM, Sabaratnam V (2015) Ganoderma neo-japonicum Imazeki revisited: domestication study and antioxidant properties of its basidiocarps and mycelia. Sci Rep 5:12515

    Article  PubMed  PubMed Central  Google Scholar 

  • Tang W, Liu JW, Zhao WM, Wei DZ, Zhong JJ (2006) Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells. Life Sci 80:205–211

    Article  CAS  PubMed  Google Scholar 

  • Thomas H, Coley HM (2003) Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting p-glycoprotein. Cancer Control 10:159–165

    Article  PubMed  Google Scholar 

  • Vrkoc J, Budesinsky M, Dolejs L (1977) Phenolic meroterpenoids from the basidiomycete Albatrellus ovinus. Phytochemistry 16:1409–1411

    Article  CAS  Google Scholar 

  • Wang CJ, Chau CF, Hsich YS, Yang SF, Yen GC (2008) Lucidenic acid inhibits PMA-induced invasion of human hepatoma cells through inactivating MAPK/ERK signal transduction pathway and reducing binding activities of NF-κB and AP-1. Carcinogenesis 29:147–156

    Article  CAS  Google Scholar 

  • Wang S, Bao L, Zhao F, Wang Q, Li S, Ren J, Li L, Wen H, Guo L, Liu H (2013) Isolation, identification and bioactivity of monoterpenoids and sesquiterpenoids from the mycelia of edible mushroom Pleurotus cornucopiae. J Agric Food Chem 61:5122–5129

    Article  CAS  PubMed  Google Scholar 

  • Wasser SP (2011) Current findings, future trends, and unsolved problems in studies of medicinal mushrooms. Appl Microbiol Biotechnol 89:1323–1332

    Article  CAS  PubMed  Google Scholar 

  • Wasser SP (2014) Medicinal mushroom science: current perspectives, advances, evidences, and challenges. Biom J 37:345–356

    Google Scholar 

  • Watanabe K, Shuto T, Sato M, Onuki K, Mizunoe S, Suzuki S, Sato T, Koga T, Suico MA, Kai H, Ikeda T (2011) Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK. Biochem Biophys Res Commun 408:18–24

    Article  CAS  PubMed  Google Scholar 

  • Weng CJ, Chau CF, Chen KD, Chen DH, Yen GC (2007) The antiinvasive effect of lucidenic acids isolated from a new Ganoderma lucidum strain. Mol Nutr Food Res 51:1472–1477

    Article  CAS  PubMed  Google Scholar 

  • Wong YY, Moon A, Duffin R, Barthet-Barateig A, Meijer HA, Clemens MJ, de Moor CH (2010) Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. J Biol Chem 285:2610–2621

    Article  CAS  PubMed  Google Scholar 

  • Wu SJ, Leu YI, Chen CH, Chao CH, Shen DY, Chan HH, Lee EJ, Wu TS, Wang YH, Shen YC, Qian K, Bastow KF, Lee KH (2010) Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from fruiting body of Taiwanofungus camphoratus. J Nat Prod 73:1756–1762

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wu GS, Lu JJ, Guo JJ, Li YB, TanW DYY, Zhong ZF, Xu ZT, Chen XP, Wang YT (2012) Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia 83:408–414

    Article  CAS  PubMed  Google Scholar 

  • Xu TT, Beelman RB, Lambert JD (2012) The cancer preventive effects of edible mushrooms. Anti-cancer Agent Me 12:1255–1263

    Article  CAS  Google Scholar 

  • Yasukawa K, Yu S-Y, Takido M (1996) Inhibitory effect of oral administration of Rikkunshito on tumor promotion in two-stage carcinogenesis in mouse skin. Journal of Traditional Medicines 13:180–184

    Google Scholar 

  • Yazawa Y, Yokota M, Sugiyama K (2000) Antitumor promoting effect of an active component of polyporus, ergosterol and related compounds on rat urinary bladder carcinogenesis in a short-term test with concanavalin a. Biol Pharm Bull 23:1298–1302

    Article  CAS  PubMed  Google Scholar 

  • Ye M, Liu JK, Lu ZX, Zhao Y, Liu SF, Li LL, Tan M, Weng XX, Li W, Cao Y (2005) Grifolin, a potential antitumor natural product from the mushroom Albatrellus confluens inhibits tumor cell growth by inducing apoptosis in vitro. FEBS Lett 579:3437–3443

    Article  CAS  PubMed  Google Scholar 

  • Yeh CT, Rao YK, Yao CJ, Yeh CF, Li CH, Chuang SE, Luong JH, Lai GM, Tzeng YM (2009) Cytotoxic triterpenes from Antrodia camphorata and their mode of action in HT-29 human colon cancer cells. Cancer Lett 285:73–79

    Article  CAS  PubMed  Google Scholar 

  • Yin X, Feng T, Li ZH, Dong ZJ, Li Y, Liu JK (2013) Highly oxygenated meroterpenoids from fruiting bodies of the mushroom Tricholoma terreum. J Nat Prod 76:1365–1368

    Article  CAS  PubMed  Google Scholar 

  • Yoshiji H, Kuriyama S, Ways DK, Yoshii J, Miyamoto Y, Kawata M, Ikenaka Y, Tsujinoue H, Nakatani T, Shibuya M, Fukui H (1999) Protein kinase C lies on the signaling pathway for vascular endothelial growth factor-mediated tumor development and angiogenesis. Cancer Res 59:4413–4418

    CAS  PubMed  Google Scholar 

  • Zaidman B, Yassin M, Mahajana J, Wasser SP (2005) Medicinal mushroom modulators of molecular targets as cancer therapeutics. Appl Microbiol Biotechnol 67:453–468

    Article  CAS  PubMed  Google Scholar 

  • Zhang Z, Liu RN, Tang QJ, Zhang JS, Yang Y, Shang XD (2015) A new diterpene from the fungal mycelia of Hericium erinaceus. Phytochem Lett 11:151–156

    Article  CAS  Google Scholar 

  • Zhao YY, Chao X, Zhang Y, Lin RC, Sun WJ (2010) Cytotoxic steroids from Polyporus Umbellatus. Planta Med 76:1755–1758

    Article  CAS  PubMed  Google Scholar 

  • Zhao YY, Shen X, Chao X, Ho CC, Cheng XL, Zhang Y, Lin RC, Du KJ, Luo WJ, Chen JY (2011) Ergosta-4, 6, 8 (14), 22-tetraen-3-one induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Biochim Biophys Acta 1810:384–390

    Article  CAS  PubMed  Google Scholar 

  • Zhou L, Shi P, Chen NH, Zhong JJ (2011) Ganoderic acid Me induces apoptosis through mitochondria dysfunctions in human colon carcinoma cells. Process Biochem 46:219–225

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, University of Calcutta, Kolkata, West Bengal, India

    Sudeshna Nandi, Rimpa Sikder & Krishnendu Acharya

Authors
  1. Sudeshna Nandi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Rimpa Sikder
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Krishnendu Acharya
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Biological Science and Engineering, Netaji Subhas University of Technology, New Delhi, Delhi, India

    Tulasi Satyanarayana

  2. Biotech & Management of Bioresources Div, The Energy and Resources Institute, New Delhi, Delhi, India

    Sunil Kumar Deshmukh

  3. Division of Biological Sciences, CSIR-National Chemical Laboratory, Pune, Maharashtra, India

    Mukund V. Deshpande

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Nandi, S., Sikder, R., Acharya, K. (2019). Secondary Metabolites of Mushrooms: A Potential Source for Anticancer Therapeutics with Translational Opportunities. In: Satyanarayana, T., Deshmukh, S., Deshpande, M. (eds) Advancing Frontiers in Mycology & Mycotechnology. Springer, Singapore. https://doi.org/10.1007/978-981-13-9349-5_23

Download citation

Publish with us

Policies and ethics

Search

Navigation