Abstract
Cancer is the second leading cause of mortality according to the current WHO report, which states that 30–50% of cancer cases can be prevented by maintaining a healthy lifestyle. One of the ways to maintain a healthy lifestyle is by consumption of healthy food containing antioxidant molecules and enzymes. Curcumin and polyphenolic compounds are now proven as anticarcinogenic molecules. The structures of these molecules are the reason for their anticarcinogenic property. There are many compounds available in nature that may be used as anticancer or antioxidant molecules. Some of these molecules have similar chemical structures and some have different structures. Moreover, in the absence of the known 3D structure of the natural compound, design and optimization of lead molecules are based on physicochemical properties and quantitative structure activity relationships. In this chapter, ligand-based designing of naturally available anticarcinogenic molecules is discussed.
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Abbreviations
- EGCG:
-
Epigallocatechin gallate
- GSH:
-
Reduced glutathione
- GST:
-
Glutathione-S-transferase
- LPO:
-
Lipid peroxidation
- QSAR:
-
Quantitative structure activity relationship
- ROS:
-
Reactive oxygen species
- SOD:
-
Superoxide dismutase
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Singh, V. et al. (2019). Ligand-Based Designing of Natural Products. In: Sharma, A. (eds) Bioactive Natural Products for the Management of Cancer: from Bench to Bedside. Springer, Singapore. https://doi.org/10.1007/978-981-13-7607-8_8
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DOI: https://doi.org/10.1007/978-981-13-7607-8_8
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