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Current Approaches of Anti-inflammatory-Dependent Antiaging Strategies

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Molecular Basis and Emerging Strategies for Anti-aging Interventions

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Abstract

Inflammation plays a role in the etiology of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s diseases, which have the highest mortality rates. It has been argued that the lifetime of macromolecular damage caused by chronic inflammation can be the cause of aging process. There are studies indicating that aging is also closely related with low-grade chronic inflammation, defined as sterile inflammation. Another definition of sterile inflammation is pathogen-free inflammation resulting from various environmental conditions such as mechanical trauma, ischemia, stress, or ultraviolet radiation. The combined effects of inflammation on genome, epigenome, mitochondria, a variety of intracellular structures, and cellular membranes need to be defied for diverse areas of eventual antiaging interventions. These interventions include specific exercise programs, caloric restriction, anti-inflammatory diets and nutritional supplements, and specific cell-based therapies including platelet-rich plasma (PRP) and stem cells as both mitigating agents in the aging process. Inflammation suppression is one of the most important factors for healthy longevity. This chapter will focus on the current approaches of anti-inflammatory-dependent antiaging strategies.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey

    Hafize Uzun

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  1. Department of Biochemistry, University of Allahabad, Allahabad, Uttar Pradesh, India

    Syed Ibrahim Rizvi

  2. Medical Biochemistry, Istanbul University, Cerrahpasa, Istanbul, Turkey

    Ufuk Çakatay

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Uzun, H. (2018). Current Approaches of Anti-inflammatory-Dependent Antiaging Strategies. In: Rizvi, S., Çakatay, U. (eds) Molecular Basis and Emerging Strategies for Anti-aging Interventions. Springer, Singapore. https://doi.org/10.1007/978-981-13-1699-9_23

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