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Growth Factor Delivery Systems for Tissue Engineering and Regenerative Medicine

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Cutting-Edge Enabling Technologies for Regenerative Medicine

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1078))

Abstract

Growth factors (GFs) are often a key component in tissue engineering and regenerative medicine approaches. In order to fully exploit the therapeutic potential of GFs, GF delivery vehicles have to meet a number of key design criteria such as providing localized delivery and mimicking the dynamic native GF expression levels and patterns. The use of biomaterials as delivery systems is the most successful strategy for controlled delivery and has been translated into different commercially available systems. However, the risk of side effects remains an issue, which is mainly attributed to insufficient control over the release profile. This book chapter reviews the current strategies, chemistries, materials and delivery vehicles employed to overcome the current limitations associated with GF therapies.

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Authors and Affiliations

  1. Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) Group, Department of Orthopaedic Surgery and Musculoskeletal Medicine, University of Otago Christchurch, Christchurch, New Zealand

    Pau Atienza-Roca, Xiaolin Cui, Gary J. Hooper, Tim B. F. Woodfield & Khoon S. Lim

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  1. Pau Atienza-Roca
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  2. Xiaolin Cui
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  3. Gary J. Hooper
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  4. Tim B. F. Woodfield
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  5. Khoon S. Lim
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Correspondence to Khoon S. Lim .

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  1. The Catholic University of Korea, Seoul, Korea (Republic of)

    Heung Jae Chun

  2. Hallym University, Gangwon-do, Korea (Republic of)

    Chan Hum Park

  3. Kyung Hee University, Seoul, Korea (Republic of)

    Il Keun Kwon

  4. Chonbuk National University, Jeonju, Korea (Republic of)

    Gilson Khang

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Atienza-Roca, P., Cui, X., Hooper, G.J., Woodfield, T.B.F., Lim, K.S. (2018). Growth Factor Delivery Systems for Tissue Engineering and Regenerative Medicine. In: Chun, H., Park, C., Kwon, I., Khang, G. (eds) Cutting-Edge Enabling Technologies for Regenerative Medicine. Advances in Experimental Medicine and Biology, vol 1078. Springer, Singapore. https://doi.org/10.1007/978-981-13-0950-2_13

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