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Inherited Neurodegenerative Disorders

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Pathology, Prevention and Therapeutics of Neurodegenerative Disease

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Abstract

Neurodegeneration is the progressive loss of function of neurons and an inescapable event in incurable diseases involving Huntington Disease (HD), Parkinson Disease (PD), and Alzheimer Disease (AD). These and other such diseases share similar pathogenic mechanisms including atypical protein assembly, oxidative pathway dysfunction, and apoptotic cellular death. Neuronal degeneration may be exhibited at different levels like neuronal circuitry aligning from molecular to systemic levels.

In this chapter, we focus on the inherited neurodegenerative diseases and their molecular pathogenesis. We will be looking into highly researched inherited neurodegenerative diseases including HD, PD, AD, and ALS and review the varied knowledge on inheritance patterns and disease mechanisms that have been documented.

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Authors and Affiliations

  1. Human Genetics Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka

    Dulika S. Sumathipala & Vajira H. W. Dissanayake

Authors
  1. Dulika S. Sumathipala
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  2. Vajira H. W. Dissanayake
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Editors and Affiliations

  1. Toxicology and Experimental Medicine Division, CSIR-Central Drug Research Institute, Lucknow, India

    Sarika Singh

  2. Department of Surgery, Samuel Oschin Comprehensive Cancer Institute, Cedar Sinai Medical Center, Los Angeles, CA, USA

    Neeraj Joshi

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Sumathipala, D.S., Dissanayake, V.H.W. (2019). Inherited Neurodegenerative Disorders. In: Singh, S., Joshi, N. (eds) Pathology, Prevention and Therapeutics of Neurodegenerative Disease. Springer, Singapore. https://doi.org/10.1007/978-981-13-0944-1_7

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  • DOI: https://doi.org/10.1007/978-981-13-0944-1_7

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  • Publisher Name: Springer, Singapore

  • Print ISBN: 978-981-13-0943-4

  • Online ISBN: 978-981-13-0944-1

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