Abstract
Stem cells proliferate by undergoing self-renewal and differentiate into multiple cell lineages in response to biochemical and biophysical stimuli. Various biochemical cues such as growth factors, nucleic acids, chemical reagents, and small molecules have been used to induce stem cell differentiation or reprogramming or to maintain their pluripotency. Moreover, biophysical cues such as matrix stiffness, substrate topography, and external stress and strain play a major role in modulating stem cell behavior. In this chapter, we have summarized microenvironmental regulation of stem cell behavior through biochemical and biophysical stimulation.
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This work was supported by a grant from the National Research Foundation (NRF) of Korea funded by the Ministry of Science, ICT & Future Planning (MSIP) (No. NRF-2016R1A2A1A05004987) and the Ministry of Education, Science and Technology (MEST) (No. NRF-2014R1A6A3A04055123).
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Choi, B., Kim, D., Han, I., Lee, SH. (2018). Microenvironmental Regulation of Stem Cell Behavior Through Biochemical and Biophysical Stimulation. In: Noh, I. (eds) Biomimetic Medical Materials. Advances in Experimental Medicine and Biology, vol 1064. Springer, Singapore. https://doi.org/10.1007/978-981-13-0445-3_9
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