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Fibrin-Based Biomaterial Applications in Tissue Engineering and Regenerative Medicine

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Biomimetic Medical Materials

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1064))

Abstract

The fibrin matrix is fundamentally formed by the polymerization of fibrinogen and thrombin in blood plasma. It is a natural biopolymeric material to widely investigate for various tissue regenerations due to good biocompatibility, rapid biodegradability, and easy fabrication. In particular, the conjugated bioactive molecules with fibrinogen can promote tissue morphogenesis or maturation after cell adhesion on the matrices, migration, proliferation, or differentiation. Using these physiological properties with cell-material interactions, the fibrin matrices have been utilized in tissue engineering applications such as skin tissue, cardiovascular tissue, musculoskeletal tissue, or nerve tissue in preclinical and clinical situations. This chapter demonstrates the fibrin material and its tissue engineering applications as the therapeutic strategies.

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Authors and Affiliations

  1. Department of Dental Biomaterials, School of Dentistry, Kyungpook National University, Daegu, South Korea

    Chan Ho Park

  2. Department of Pharmacology & Dental Therapeutics, Dental Research Institute and BK21 Program, School of Dentistry, Seoul National University, Seoul, South Korea

    Kyung Mi Woo

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  1. Chan Ho Park
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Correspondence to Kyung Mi Woo .

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  1. Seoul National University, Seoul, Korea (Republic of)

    Insup Noh

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Park, C.H., Woo, K.M. (2018). Fibrin-Based Biomaterial Applications in Tissue Engineering and Regenerative Medicine. In: Noh, I. (eds) Biomimetic Medical Materials. Advances in Experimental Medicine and Biology, vol 1064. Springer, Singapore. https://doi.org/10.1007/978-981-13-0445-3_16

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