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Role of Hysteroscopy in ART

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Manual of Fertility Enhancing Hysteroscopy

Abstract

The process of assisted reproductive technologies (ART) has evolved over a period of time, and hysteroscopy has become an integral part of it. Assessment of the uterine cavity before ART helps in finding and treating many conditions which can directly affect the outcome, and it also helps in ways not fully understood to improve the success rate. Most common findings on hysteroscopy are polyp, septum, and myoma, apart from many other significant findings. Endometrial polyp has been shown to significantly hamper the implantation rate, and its removal improves the ART outcome. Septum has more commonly been related to miscarriages, but its removal before ART can improve the take-home baby rate. Larger myomas close to uterine cavity have been shown to significantly hamper fertility, and myomectomy can significantly improve the success rate. Hysteroscopy through artificial endometrial injury prior to first IVF cycle or in previously failed cycles can enhance implantation rates. Recently, hysteroscopy has been utilized for tubal occlusion and cervical refashioning in difficult embryo transfers. Hysteroscopic embryo transfer is a concept which requires further evaluation and research.

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References

  1. Prevedourakis C, Loutradis D, Kalianidis C, Markis N, Asavantinos D. Hysterosalpingography and hysteroscopy in female infertility. Hum Reprod. 1994;9:2353–5.

    Article  CAS  PubMed  Google Scholar 

  2. Ait Benkaddour Y, Gervaise A, Fernandez H. Which is the method of choice for evaluating uterine cavity in infertility workup? Gynecol Obstet Biol Reprod. 2010;39(8):606–13.

    Article  CAS  Google Scholar 

  3. Fabres C, Alam V, Balmaceda J. Comparison of ultrasonography and hysteroscopy in the diagnosis of intrauterine lesions in infertile women. J Am Assoc Gynecol Laparosc. 1998;5:375–8.

    Article  CAS  PubMed  Google Scholar 

  4. Meizner I, Shokeir TA. Predictive value of TVUS performed before routine diagnostic hysteroscopy for evaluation of infertility. Fertil Steril. 2000;37:593–610.

    Google Scholar 

  5. Cunha-Filho JSL, Souza CAB, Salazar CC, Facin AC, Freitas FM, Passos EP. Accuracy of HSG and hysteroscopy for diagnosis of intrauterine lesions in infertile patients in an assisted fertilization programme. Gynecol Endosc. 2001;10:45–8.

    Article  Google Scholar 

  6. Bettocchi S, Nappi L, Ceci O. Office hysteroscopy. Obstet Gynecol Clin North Am. 2004;31:641–54.

    Article  PubMed  Google Scholar 

  7. Polisseni F, Bambirra EA, Camargos AF. Detection of chronic endometritis by diagnostic hysteroscopy in asymptomatic infertile patients. Gynecol Obstet Invest. 2003;55:205–10.

    Article  PubMed  Google Scholar 

  8. Doldi N, Prsico P, Di Sebastiano F, et al. Pathologic findings in hysteroscopy before in vitro fertilization-embryo transfer (IVF-ET). Gynecol Endocrinol. 2005;21:235–7.

    Article  PubMed  Google Scholar 

  9. Pellicano M, Guida M, Zullo F, Lavitola G, Cirillo D, Nappi C. Carbon dioxide versus normal saline as a uterine distention medium for diagnostic vaginoscopic hysteroscopy in infertile patients. Fertil Steril. 2003;79:418–21.

    Article  PubMed  Google Scholar 

  10. Di Spiezio Sardo A, Bettocchi S, Spinelli M, Guida M, Nappi L, Angioni S, Sosa Fernandez LM, Nappi C. Review of new office-based hysteroscopic procedures 2003-2009. J Minim Invasive Gynecol. 2010;17(4):436–48.

    Article  PubMed  Google Scholar 

  11. Oliveira FG, Abdelmassih VG, Diamond MP, Dozortsev D, Nagy ZP, Abdelmassih R. Uterine cavity findings and hysteroscopic interventions in patients undergoing in vitro fertilization-embryo transfer who repeatedly cannot conceive. Fertil Steril. 2003;80:1371–5.

    Article  PubMed  Google Scholar 

  12. Demirol A, Gurgan T. Effect of treatment of intrauterine pathologies with office hysteroscopy in patients with recurrent IVF failure. Reprod Biomed Online. 2004;8:590–4.

    Article  PubMed  Google Scholar 

  13. Hinckley MD, Milki AA. 1000 office-based hysteroscopies prior to in vitro fertilization: feasibility and findings. JSLS. 2004;8:103–7.

    PubMed  PubMed Central  Google Scholar 

  14. Rama Raju GA, Shashi KG, Krishna KM, Prakash GJ, Madan K. Assessment of uterine cavity by hysteroscopy in assisted reproduction programme and its influence on pregnancy outcome. Arch Gynecol Obstet. 2006;274:160–4.

    Article  CAS  PubMed  Google Scholar 

  15. Karayalcin R, Ozcan S, Moraloglu O, Ozyer S, Mollamahmutoglu L, Batıoglu S. Results of 2500 office-based diagnostic hysteroscopies before IVF. Reprod BioMedicine Online. 2010;20:689–93.

    Article  Google Scholar 

  16. Day Baird D, Dunson DB, Hill MC, Cousins D, Schectman JM. High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence. Am J Obstet Gynecol. 2003;188:100–7.

    Article  Google Scholar 

  17. Donnez J, Jadoul P. What are the implications of myomas on fertility? A need for a debate? Hum Reprod. 2002;17:1424–30.

    Article  CAS  PubMed  Google Scholar 

  18. Pritts EA. Fibroids and infertility: a systematic review of the evidence. Obstet Gynecol Surv. 2001;56:483–91.

    Article  CAS  PubMed  Google Scholar 

  19. Sudik R, Husch K, Steller J, Daume E. Fertility and pregnancy outcome after myomectomy in sterility patients. Eur J Obstet Gynecol Reprod Biol. 1996;65:209–14.

    Article  CAS  PubMed  Google Scholar 

  20. Matsuzaki S, Canis M, Darcha C, Pouly JL, Mage G. HOXA-10 expression in the mid-secretory endometrium of infertile patients with either endometriosis, uterine fibromas or unexplained infertility. Hum Reprod. 2009;24:3180–7.

    Article  CAS  PubMed  Google Scholar 

  21. Rackow BW, Taylor HS. Submucosal uterine leiomyomas have a global effect on molecular determinants of endometrial receptivity. Fertil Steril. 2010;93:2027–34.

    Article  CAS  PubMed  Google Scholar 

  22. Bosteels J, Kasius J, Weyers S, Broekmans FJ, Mol BWJ, D’Hooghe TM. Hysteroscopy for treating subfertility associated with suspected major uterine cavity abnormalities. Cochrane Database Syst Rev. 2015;2:CD009461.

    Google Scholar 

  23. Ben-Nagi J, Miell J, Yazbek J, Holland T, Jurkovic D. The effect of hysteroscopic polypectomy on the concentrations of endometrial implantation factors in uterine flushings. Reprod Biomed Online. 2009;19:737–44.

    Article  CAS  PubMed  Google Scholar 

  24. Peng X, Li T, Xia E, Xia C, Liu Y, Yu D. A comparison of oestrogen receptor and progesterone receptor expression in endometrial polyps and endometrium of premenopausal women. J Obstet Gynaecol. 2009;29:340–6.

    Article  CAS  PubMed  Google Scholar 

  25. Kim MR, Kim YA, Jo MY, Hwang KJ, Ryu HS. High frequency of endometrial polyps in endometriosis. J Am Assoc Gynecol Laparosc. 2003;10:46–8.

    Article  PubMed  Google Scholar 

  26. de Sa Rosa e de Silva AC, Rosa e Silva JC, Candido dos Reis FJ, Nogueira AA, Ferriani RA. Routine office hysteroscopy in the investigation of infertile couples before assisted reproduction. J Reprod Med. 2005;50:501–6.

    Google Scholar 

  27. Perez-Medina T, Bajo-Arenas J, Salazar F, Redondo T, Sanfrutos L, Alvarez P, Engels V. Endometrial polyps and their implication in the pregnancy rates of patients undergoing intrauterine insemination: a prospective, randomized study. Hum Reprod. 2005;20:1632–5.

    Article  PubMed  Google Scholar 

  28. Varasteh NN, Neuwirth RS, Levin B, Keltz MD. Pregnancy rates after hysteroscopic polypectomy and myomectomy in infertile women. Obstet Gynecol. 1999;94:168–71.

    CAS  PubMed  Google Scholar 

  29. Spiewankiewicz B, Stelmachow J, Sawicki W, Cendrowski K, Wypych P, Swiderska K. The effectiveness of hysteroscopic polypectomy in cases of female infertility. Clin Exp Obstet Gynecol. 2003;30:23–5.

    CAS  PubMed  Google Scholar 

  30. Shokeir TA, Shalan HM, El-Shafei MM. Significance of endometrial polyps detected hysteroscopically in eumenorrheic infertile women. J Obstet Gynaecol Res. 2004;30:84–9.

    Article  PubMed  Google Scholar 

  31. Devi Wold AS, Pham N, Arici A. Anatomic factors in recurrent pregnancy loss. Semin Reprod Med. 2006;24:25–32.

    Article  PubMed  Google Scholar 

  32. Romero R, Espinoza J, Mazor M. Can endometrial infection/inflammation explain implantation failure, spontaneous abortion, and preterm birth after in vitro fertilization? Fertil Steril. 2004;82:799–804.

    Article  PubMed  Google Scholar 

  33. Feghali J, Bakar J, Mayenga JM, Segard L, Hamou J, Driguez P, Belaisch-Allart J. Systematic hysteroscopy prior to in vitro fertilization. Gynecol Obstet Fertil. 2003;31:127–31.

    Article  CAS  PubMed  Google Scholar 

  34. Varma TR. Genital tuberculosis and subsequent fertility. Int J Gynaecol Obstet. 1991;35:1–11.

    Article  CAS  PubMed  Google Scholar 

  35. Kodaman PH, Arici A. Intrauterine adhesions and fertility outcome: how to optimize success? Curr Opin Obstet Gynecol. 2007;19(3):207–14.

    Article  PubMed  Google Scholar 

  36. Garbin O, Ziane A, Castaigne V, Rongières C. Do hysteroscopic metroplasties really improve reproductive outcome? Gynecol Obstet Fertil. 2006;34(9):813–8.

    Article  CAS  PubMed  Google Scholar 

  37. Mollo A, De Franciscis P, Colacurci N, Cobellis L, Perino A, Venezia R, Alviggi C, De Placido G. Hysteroscopic resection of the septum improves the pregnancy rate of women with unexplained infertility: a prospective controlled trial. Fertil Steril. 2009;91(6):2628–31.

    Article  PubMed  Google Scholar 

  38. Taylor E, Gomel V. The uterus and fertility. Fertil Steril. 2008;89(1):1–16.

    Article  PubMed  Google Scholar 

  39. Bosteels J, Weyers S, Puttemans P, Panayotidis C, Van Herendael B, Gomel V, Mol BW, Mathieu C, D’Hooghe T. The effectiveness of hysteroscopy in improving pregnancy rates in subfertile women without other gynaecological symptoms: a systematic review. Hum Reprod Update. 2010;16:1–11.

    Article  PubMed  Google Scholar 

  40. El-Toukhy T, Sunkara SK, Coomarasamy A, Grace J, Khalaf Y. Outpatient hysteroscopy and subsequent IVF cycle outcome: a systematic review and meta-analysis. Reprod Biomed Online. 2008;16:712–9.

    Article  PubMed  Google Scholar 

  41. Nastri CO, Lensen SF, Gibreel A, Raine-Fenning N, Ferriani RA, Bhattacharya S, et al. Endometrial injury in women undergoing assisted reproductive techniques. Cochrane Database Syst Rev. 2015;3:CD009517.

    Google Scholar 

  42. Pundir J, Pundir V, Omanwa K, Khalaf Y, El-Toukhy T. Hysteroscopy prior to the first IVF cycle: a systematic review and meta-analysis. Reprod Biomed Online. 2014;28:151–61.

    Article  PubMed  Google Scholar 

  43. Dhulkotia J, Coughlan C, Li TC, Ola B. Effect of endometrial injury on subsequent pregnancy rates in women undergoing IVF after previous implantation failure: systematic review and meta-analysis. BJOG. 2012;119:132–3.

    Google Scholar 

  44. El-Toukhy T, Sunkara S, Khalaf Y. Local endometrial injury and IVF outcome: a systematic review and meta-analysis. Reprod Biomed Online. 2012;25:345–54.

    Article  PubMed  Google Scholar 

  45. Potdar N, Gelbaya T, Nardo LG. Endometrial injury to overcome recurrent embryo implantation failure: a systematic review and meta-analysis. Reprod Biomed Online. 2012;25:561–71.

    Article  PubMed  Google Scholar 

  46. Li R, Hao G. Local injury to the endometrium: its effect on implantation. Cur Opin. Obstet Gynecol. 2009;21:236–9.

    Article  CAS  Google Scholar 

  47. Haider S, Knöfler M. Human tumor necrosis factor: physiological and pathological roles in placenta and endometrium. Placenta. 2009;30:111–23.

    Article  CAS  PubMed  Google Scholar 

  48. Gnainsky Y, Granot I, Aldo PB, Barash A, Or Y, Schechtman E, et al. Local injury of the endometrium induces an inflammatory response that promotes successful implantation. Fertil Steril. 2010;94:2030–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Díaz-Gimeno P, Horcajadas JA, Martínez-Conejero JA, Esteban FJ, Alama P, Pellicer A, et al. A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature. Fertil Steril. 2011;95:50–60.

    Article  PubMed  Google Scholar 

  50. Díaz-Gimeno P, Ruiz-Alonso M, Blesa D, Bosch N, Martínez-Conejero JA, Alama P, et al. The accuracy and reproducibility of the endometrial receptivity array is superior to histological dating as diagnostic method for the endometrial factor. Fertil Steril. 2013;99:508–17.

    Article  PubMed  Google Scholar 

  51. Kilani Z. Live birth after hysteroscopic-guided embryo transfer: a case report. Fertil Steril. 2009;91:2733.e1–2.

    Article  Google Scholar 

  52. Abou-Setta AM, Al-Inany HG, Mansour RT, Serour GI, Aboulghar MA. Effectiveness of hysteroscopic embryo transfer: a systematic review and meta-analysis with an indirect comparison of randomized trials. Fertil Steril. 2005;84:S363.

    Article  Google Scholar 

  53. Strandell A, Lindhard A, Waldenström U, Thorburn J, Janson PO, Hamberger L. Hydrosalpinx and IVF outcome: a prospective, randomized multicentre trial in Scandinavia on salpingectomy prior to IVF. Hum Reprod. 1999;14(11):2762–9.

    Article  CAS  PubMed  Google Scholar 

  54. Darwish AM, El Saman AM. Is there a role for hysteroscopic tubal occlusion of functionless hydrosalpinges prior to IVF/ICSI in modern practice. Acta Obstet Gynecol Scand. 2007;86(12):1484–9.

    Article  PubMed  Google Scholar 

  55. Visser DS, Fourie F, Kruger HF. Multiple attempts at embryo transfer: effect on pregnancy outcome in an in vitro fertilization and embryo transfer program. J Assist Reprod Genet. 1993;10:37–43.

    Article  CAS  PubMed  Google Scholar 

  56. Noyes N. Hysteroscopic cervical canal shaving: a new therapy for cervical stenosis before embryo transfer in patients undergoing in vitro fertilization. Fertil Steril. 1999;71:965–6.

    Article  CAS  PubMed  Google Scholar 

  57. Mahajan N, Gupta I. Use of Versapoint to refashion the cervical canal to overcome unusually difficult embryo transfers and improve in-vitro fertilization-embryo transfer outcome: a case series. J Hum Reprod Sci. 2011;4(1):12–6.

    Article  PubMed  PubMed Central  Google Scholar 

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Hitnalikar, P. (2018). Role of Hysteroscopy in ART. In: Jain, S., Inamdar, D. (eds) Manual of Fertility Enhancing Hysteroscopy. Springer, Singapore. https://doi.org/10.1007/978-981-10-8028-9_9

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  • DOI: https://doi.org/10.1007/978-981-10-8028-9_9

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