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Acid- and Redox-Responsive Smart Polymeric Nanomaterials for Controlled Drug Delivery

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In Vivo Self-Assembly Nanotechnology for Biomedical Applications

Part of the book series: Nanomedicine and Nanotoxicology ((NANOMED))

Abstract

In cancer therapy, the lack of selectivity of anticancer drug remains a major challenge for chemotherapy. Polymeric nanomaterials have enabled more effective drug design and development through tumor passive and active targeted drug delivery strategies. Considering the possible inefficient drug release at the tumor site, stimuli-responsive chemical bonds were introduced into the polymeric nanocarriers for controlled drug release and enhanced therapeutic efficacy toward tumor. Numerous external and internal stimuli were applied to trigger the chemical structure change of polymeric nanovehicles, causing microstructural rearrangement, hydrophilic/hydrophobic balance transformation, or disassembly into single polymer chains. Characteristic changes in tumor site such as pH (~pH 6.8 in tumor microenvironment and ~pH 5–6 in endosomes/lysosomes) or reductive/oxidative gradients in cytoplasm/mitochondria have been investigated extensively as internal stimuli for triggering drug release from polymeric nanocarriers. Therefore, it is important to develop acid- and redox-responsive polymeric nanomaterials as potential anticancer nanodrugs. In this review, we summarize recent progress in the preparation of these responsive polymers and their applications in anticancer drug delivery. We will focus on chemical structure, stimuli-responsive bond, self-assembly property, and drug release behavior of polymeric nanomaterials, which may offer a guide for optimal design of smart targeted nanodrugs in clinical cancer treatment.

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  1. CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), No. 11 Beiyitiao, Zhongguancun, Beijing, China

    Zeng-Ying Qiao & Yu-Juan Gao

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    Hao Wang

  2. CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing, China

    Li-Li Li

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Qiao, ZY., Gao, YJ. (2018). Acid- and Redox-Responsive Smart Polymeric Nanomaterials for Controlled Drug Delivery. In: Wang, H., Li, LL. (eds) In Vivo Self-Assembly Nanotechnology for Biomedical Applications. Nanomedicine and Nanotoxicology. Springer, Singapore. https://doi.org/10.1007/978-981-10-6913-0_5

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