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The antagonist analgesic concept

  • Chapter
The Dependence Phenomenon

Abstract

One of the prime objectives of medical research over the past 50 years has been the discovery and development of an analgesic agent having the efficacy of morphine without the liability to abuse which characterizes the narcotics. All the opioid drugs introduced during this period have claimed superiority over morphine in terms of abuse potential. Most of them have ultimately failed to live up to the full extent of the claims made; nevertheless several widely used drugs have been less abused than morphine.

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References

  • Aceto, M. D., Harris, L. S., Balster, R. L. and Dewey, W. L. In: Minutes of Thirty- Sixth Annual Scientific Meeting, Committee on Problems of Drug Dependence, Mexico City, pp. 77–87

    Google Scholar 

  • Adriaensen, H. and Van de Walle, J. (1976). Acta Anaesth. Belg., 27, 183

    Google Scholar 

  • Archer, S., Albertson, N. F., Harris, L. S., Pierson, A. K. and Bird, J. G. (1964). J. Med. Chem., 7, 123–127

    Article  Google Scholar 

  • Ariens, E. J., Simonis, A. M. and Van Rossum, J. M. (1964). Molecular Pharmacology: The Mode of Action of Biologically Active Compounds. ( New York: Academic Press )

    Google Scholar 

  • Brogden, R. N., Speight, T. M. and Avery, G. S. (1973). Drugs, 5, 6–91

    Article  Google Scholar 

  • De Castro, J. and Parmentier, P. (1976). In Huzler, E. (ed.) Anesthesiology, Proceedings of the Sixth World Congress of Anaesthesiology, Mexico City, pp. 103–105. ( Amersterdam: Excerpta Medica International Series No. 399 )

    Google Scholar 

  • Cowan, A. (1974). In: Narcotic Antagonists. Advances in Biochemical Psychopharmacology. Vol. 8. Braude, M. C., Harris, L. S., May, E. L., Smith, J. P. and Villarreal, J. E. (eds.) (New York: Raven Press )

    Google Scholar 

  • Deneau, G. A. (1956). Dessertation for PhD degree, University of Michigan

    Google Scholar 

  • Deneau, G., Yanagita, T. and Seevers, M. H. (1969). Psychopharmacologia (Berl.), 16, 30

    Article  Google Scholar 

  • Dum, J., Bläsig, J. and Herz, A. (1981). Eur. J. Pharmacol., 70, 293

    Article  Google Scholar 

  • Edge, W. G., Cooper, G. M. and Morgan, M. (1979). Anaesthesia, 34, 463

    Article  Google Scholar 

  • Elliott, H. W., Navarro, G. and Nomoff, N. (1970). J. Med., 1, 74

    Article  Google Scholar 

  • Forrest, W. H., Brown, C. R., Schrott, P. and Teutsch, G. (1972). J. Clin. Pharmacol., 12, 440

    Google Scholar 

  • Fraser, H. F. and Isbell, H. (1960a), Bull. Narcot., 12, 9

    Google Scholar 

  • Fraser, H. F. and Isbell, H. (1960b). Bull. Narcot., 12, 15

    Google Scholar 

  • Fraser, H. F., Van Horn, G. D., Martin, W. R., Wolbach, A. B. and Isbell, H. (1961). J. Pharmacol. Exp. Ther., 133, 371

    Google Scholar 

  • Gilbert, P. E. and Martin, W. R. (1976). J. Pharmacol. Exp. Ther., 198, 66

    Google Scholar 

  • Haertzen, C. A. (1966). Psychol. Rep., 18, 163

    Article  Google Scholar 

  • Haertzen, C. A. (1970). Psychopharmacologia (Berl.), 18, 366

    Article  Google Scholar 

  • Himmelsbach, C. K. (1934). J. Am. Med. Assoc., 103, 1420

    Article  Google Scholar 

  • Himmelsbach, C. K. (1942). J. Pharmacol. Exp. Ther., 75, 64

    Google Scholar 

  • Himmelsbach, C. K. (1943). J. Pharmacol. Exp. Ther., 79, 5

    Google Scholar 

  • Hoffmeister, F. and Wuttke, W. (1973). Psychopharmacologia [Berl.], 33, 247

    Article  Google Scholar 

  • Houde, R. W. and Wallenstein, S. L. (1956). Fed. Proc., 15, 440

    Google Scholar 

  • Houde, R. W. (1974). In Bonica, J. J. Advances in Neurology. Vol. 4, pp. 527–536. ( New York: Raven Press )

    Google Scholar 

  • Houde, R. W., Wallenstein, S. L., Rogers, A. and Kaiko, R. F. In Bonica, J. J. and Albe-Fessard, D. (eds.), Advances in Pain Research and Therapy, Vol. 1, pp. 647–751 (New York: Raven Press)

    Google Scholar 

  • Houde, R. W., Wallenstein, S. L., Rogers, A. and Kaiko, R. F. (1977). In: Minutes of Thirty-Ninth Scientific Meeting, Committee on Problems of Drug Dependence, Inc., pp. 183–216

    Google Scholar 

  • Houde, R. W. (1979). Br. J. Clin. Pharmacol., 7, 297S

    Google Scholar 

  • Hughes, J., Smith, T. W., Kosterlitz, H. W., Fothergill, L. A., Morgan, B. A. and Morris, H. R. (1975). Nature (London), 258, 577

    Article  Google Scholar 

  • Isbell, H. (1956). Fed. Proc., 15, 442

    Google Scholar 

  • Inciardi, J. A. and Chambers, C. D. (1971). N.Y. State J. Med., 71, 1727

    Google Scholar 

  • Jasinski, D. R., Martin, W. R. and Hoeldtke, R. D. (1970). Clin. Pharmacol. Ther., 11, 385

    Google Scholar 

  • Jasinski, D. R., Martin, W. R. and Hoeldtke, R. D. (1971). Clin. Pharmacol. Ther., 12, 613

    Google Scholar 

  • Jasinski, D. R. and Mansky, P. (1972). Clin. Pharmacol. Ther., 13, 78

    Google Scholar 

  • Jasinski, D. R., Pevnick, J. S. and Griffith, J. D. (1978). Arch. Gen. Psychiatry, 35, 501

    Article  Google Scholar 

  • Jasinski, D. R. (1977). In Martin, W. R. Drug Addiction I. pp. 197–258 ( Berlin, Heidelberg and New York: Springer-Verlag )

    Google Scholar 

  • Jasinski, D. R. (1979). Br. J. Clin. Pharmacol., 7, 287S

    Google Scholar 

  • Kay, B. (1978). Br. J. Anaesth., 50 (6), 605

    Google Scholar 

  • Kolb, L. and Himmelsbach, C. K. (1938). Am. J. Psychiatry, 94, 759

    Google Scholar 

  • Lasagna, L. and Beecher, H. K. (1954). J. Pharmacol. Exp. Ther., 112, 356

    Google Scholar 

  • Lewis, J. W. and Ranee, M. J. (1979). Pharmaceut. J., 222, 61

    Google Scholar 

  • Martin, W. R. and Gorodetsky, C. W. (1965). J. Pharmacol Exp. Ther., 150, 437

    Google Scholar 

  • Martin, W. R., Fräser, H. F., Gorodetsky, G. W. and Rosenberg, D. E. (1965). J. Pharmacol Exp. Ther., 150, 426

    Google Scholar 

  • Martin, W. R. (1967). Pharmacol Rev., 19, 463

    Google Scholar 

  • Martin, W. R. (1977). In Martin, W. R. (ed.) Drug Addiction I. pp. 3–40 ( Berlin, Heidelberg and New York: Springer-Verlag )

    Google Scholar 

  • Martin, W. R., Eades, C. G., Thompson, W. O., Thompson, J. A. and Flanary, H. G. (1974). J. Pharmacol Exp. Ther., 189, 759

    Google Scholar 

  • Martin, W. R., Eades, C. G. Thompson, J. A., Huppier, R. E. and Gilbert, P. E. (1976). J. Pharmacol Exp. Ther., 197, 517

    Google Scholar 

  • Mello, N. K. and Mendelson, J. H. (1980). Science, 207, 657

    Article  Google Scholar 

  • Mello, N. K., Bree, M. P. and Mendelson, J. H. (1981). Pharmacol Biochem. Behav. (In Press)

    Google Scholar 

  • Pert, C. B. and Snyder, S. (1973). Science, 179, 1011

    Article  Google Scholar 

  • Podilla, R. S., Becker, L. F., Hoffman, H. et al. (1978). Arch. Dermatol, 115, 975

    Google Scholar 

  • Rance, M. J. and Dickens, J. M. (1978). In Van Ree, J. M. and Terenius, L. (ed.) Characteristics and Function of Opioids, pp. 65–66. ( Amsterdam: North Holland )

    Google Scholar 

  • Rance, M. J. (1979). Br. J. Clin. Pharmacol, 7, 281S

    Google Scholar 

  • Schuster, C. R., Smith, B. B. and Jaffe, J. H. (1971). Arch. Gen. Psychiatry, 24, 359

    Article  Google Scholar 

  • Schlicting, U. U. and Hoffmeister, F. (1971). Naunyn-Schmiedebergs Arch. Exp. Pathol Pharmacol, Suppl. to Vol. 270, R123

    Google Scholar 

  • Showalter, G. V. (1980). J. Am. Med. Assoc., 244, 1224

    Article  Google Scholar 

  • Simon, E. J., Hiller, J. M. and Edelman, I. (1973). Proc. Natl Acad. Sci., USA, 70, 1947

    Article  Google Scholar 

  • Smith, G. M. and Beecher, H. K. (1962). J. Pharmacol Exp. Ther., 136, 47

    Google Scholar 

  • Swain, H. H. and Seevers, M. H. (1975). In Minutes of Thirty-Seventh Scientific Meeting. Committee on Problems of Drug Dependence, pp. 773–795

    Google Scholar 

  • Swanson, D. W., Weddige, R. L. and Morse, R. M. (1973). Mayo Clin. Proc., 48, 85–93

    Google Scholar 

  • Teiger, D. G. (1974). J. Pharmacol Exp. Ther., 190, 408

    Google Scholar 

  • Terenius, L. (1973). Acta Pharmacol Toxicol, 32, 317

    Article  Google Scholar 

  • Von Braun, J., Kuhn, M. and Siffiqui, S. (1926). Ber. Dtsch. Chem. Ges., 59, 1081

    Article  Google Scholar 

  • Van Felsinger, J. M., Lasagna, L. and Beecher, H. K. (1955). J. Am. Med. Assoc., 157, 1113

    Article  Google Scholar 

  • Villarreal, J. E. (1972). In Kosterlitz, H. W., Collier, H. O. J. and Villarreal, J. E. (eds.) Agonist and Antagonist Actions of Narcotic Analgesic Drugs. (Proceedings of Symposium of the British Pharmacological Society, Aberdeen, July 1971 ), ( London: Macmillan Press )

    Google Scholar 

  • Villarreal, J. E. and Karbowski, M. G. (1974). In Braude, M. C., Harris, L. S., May, E. L., Smith, J. P. and Villarreal, J. E. (eds.) Narcotics Antagonists. Advances in Biochemical Psychopharmacology. Vol 8 ( New York: Raven Press )

    Google Scholar 

  • Wetli, C. V. and Bednorczyk, L. R. (1980). S. Afr. Med. J., 73, 1205

    Google Scholar 

  • Woods, J. H. (1977). In Minutes of Thirty-Ninth Annual Scientific Meeting, Committee on Problems of Drug Dependence, Inc., pp. 420–437

    Google Scholar 

  • Woods, J. H. (1978). In: Minutes of Fortieth Annual Scientific Meeting, Committee on Problems of Drug Dependence, Inc., p. 658

    Google Scholar 

  • Woods, J. H., Medzihradsky, F., Smith, G. B., Young, A. M. and Swain, H. H. (1980). Reported to Forty-Second Scientific Meeting, Committee on Problems of Drug Dependence, Inc.

    Google Scholar 

  • Wikler, A., Fräser, H. F. and Isbell, H. (1953). J. Pharmacol Exp. Ther., 109, 8

    Google Scholar 

  • Yanagita, T. (1973). Bull. Narcot., 25 (4), 57

    Google Scholar 

  • Yanagita, T. (1975). Pharmacol. Rev., 27, 503

    Google Scholar 

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Lewis, J.W. (1982). The antagonist analgesic concept. In: Glatt, M.M., Marks, J. (eds) The Dependence Phenomenon. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-7457-2_4

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  • DOI: https://doi.org/10.1007/978-94-011-7457-2_4

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