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Imaging Techniques In Studies Of Neural Functions

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Advances in Metabolic Mapping Techniques for Brain Imaging of Behavioral and Learning Functions

Part of the book series: NATO ASI Series ((ASID,volume 68))

Abstract

Imaging of morphological and structural properties of the nervous system by visual and optical techniques has been employed for more than a century and has progressed from postmortem histological examination of tissues to computerized tomographic x-ray and proton magnetic resonance imaging in vivo. Techniques for imaging of dynamic physiological and biochemical processes has become available only recently. Imaging of function-related processes in brain was initially carried out by measurements of local cerebral blood flow, first in animals with a quantitative autoradiographic technique and subsequently in man with external detection of radioactivity by scintillation counting and single photon or positron emission tomography. More recently, the deoxyglucose method, which also employs quantitative autoradiography but measures local cerebral rates of glucose utilization rather than blood flow, has become available and has been widely used to study effects of altered physiological and pharmacological states. The deoxyglucose method has also been adapted for use in man with positron emission tomography. Both local blood flow and energy metabolism are markers for local functional activity in neural tissues, and these methods have been extensively used to map functional neural pathways and to relate altered local functional activities to behavioral states in both animals and man. Comparable methods for imaging local densities and occupancies for dopaminergic, muscarinic, and opiate receptors are under development.

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Authors and Affiliations

  1. Laboratory of Cerebral Metabolism, National Institute of Mental Health, Building 36, Room 1A-05, Bethesda, Maryland, 20892, USA

    L. Sokoloff

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  1. Department of Psychology, University of Texas, Austin, TX, USA

    F. Gonzalez-Lima

  2. Schering AG, Berlin, Germany

    Th. Finkenstädt

  3. Institute for Zoology, Technical University, Darmstadt, Germany

    H. Scheich

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© 1992 Kluwer Academic Publishers

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Sokoloff, L. (1992). Imaging Techniques In Studies Of Neural Functions. In: Gonzalez-Lima, F., Finkenstädt, T., Scheich, H. (eds) Advances in Metabolic Mapping Techniques for Brain Imaging of Behavioral and Learning Functions. NATO ASI Series, vol 68. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-2712-7_1

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