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B cell responses in H. pylori infection

  • Chapter
Helicobacter pylori

Abstract

In the past the main impetus for investigating host B cell responses during H. pylori infection has been the need to develop accurate, non-invasive serodiagnostic tests. More recently the role of antibodies in the disease process, and the possibility of immunotherapy or vaccination, have become important research areas. In addition H. pylori has provided a unique opportunity for the immunologist to study immune responses to an infection at this unusual mucosal site.

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References

  1. Rathbone BJ, Wyatt JI, Worsley BW et al. Systemic and local antibody responses to gastric Campylobacter pyloridis in non-ulcer dyspepsia. Gut. 1986;27:642–7.

    Article  PubMed  CAS  Google Scholar 

  2. Steer HW, Hawtin PR, Newell DG. An ELISA technique for the serodiagnosis of Campylobacter pyloridis infection in patients with gastritis and benign duodenal ulceration. Serodiagn Immunotherapy. 1987;1:253–9.

    Article  Google Scholar 

  3. Czinn SJ, Carr HS, Speck WT. Diagnosis of gastritis caused by Helicobacter pylori in children by means of an ELISA. Rev Infect Dis. 1991;13(Supp1.8):S700–3.

    Article  PubMed  Google Scholar 

  4. Crabtree JE, Mahony MJ, Taylor JD, Heatley RV, Littlewood JM, Tompkins DS. Immune responses to Helicobacter pylori in children with recurrent abdominal pain. J Clin Pathol. 1991;44:768–71.

    Article  PubMed  CAS  Google Scholar 

  5. Morris A, Nicholson G. Ingestion of Campylobacter pyloridis causes gastritis and raised fasting pH. Am J Gastroenterol. 1987;82:192–9.

    PubMed  CAS  Google Scholar 

  6. Morris A, Nicholson G. Campylobacter pylori: human ingestion studies. In: Rathbone, BJ, Heatley RV, editors. Campylobacter pylori and gastroduodenal disease. Oxford: Blackwell Scientific Publications; 1989:185–9.

    Google Scholar 

  7. Sobala GM, Crabtree JE, Dixon MF. Acute Helicobacter pylori infection: clinical features, local and systemic immune responses, gastric mucosal histology and gastric juice ascorbic acid concentrations. Gut. 1991;32:1415–18.

    Article  PubMed  CAS  Google Scholar 

  8. Langenberg W, Rauws EAJ, Houthoff RI et al. Follow-up of individuals with untreated Campylobacter pylori-associated gastritis and of non-infected persons with non-ulcer dyspepsia. J Infect Dis. 1988;157:1245–8.

    Article  PubMed  CAS  Google Scholar 

  9. Stacey AR, Bell GD, Newell DG. The value of class and subclass ELISAs and antibody specificity in monitoring treatment of H. pylori. In: Gasbarrini G, Pretolani S, editors. Basic and clinical aspects of Helicobacter pylori infection. Berlin, Springer-Verlag; 1993:159–63.

    Google Scholar 

  10. Bonktes HJ, Veenend RA, Pena AS et al. IgG subclass response to Helicobacter pylori in patients with chronic active gastritis and duodenal ulcer. Scand J Gastroenterol. 1992;27:129–33.

    Article  Google Scholar 

  11. Van der Est MMC, Veenendaal RA, Pena AS, Van Duijn W, Kuiper I, Lamers CBHW. ELISA analysis of IgA subclass antibodies to Helicobacter pylori. Elevated serum IgAl antibodies in Helicobacter pylori infected patients. J Clin Nutr Gastroenterol. 1990;5:185–90.

    Google Scholar 

  12. Faulde M, Schroder JP, Sobe D. Serodiagnosis of Helicobacter pylori infections by detection of immunoglobulin G antibodies using an immunoblot technique and enzyme immunoassay. Eur J Clin Infect Dis. 1992;11:589–94.

    Article  CAS  Google Scholar 

  13. Kirchner T, Melber A, Fischbach W, Heilmann KL, Muller-Hermelink HK Immunohistochemical patterns of the local immune response in Helicobacter pylori gastritis. In: Malfertheiner P, Ditschuneit H, editors. Helicobacter pylori, gastritis and peptic ulcer. Berlin, Springer-Verlag; 1990:213–22.

    Chapter  Google Scholar 

  14. Valnes K, Brandtzaeg P, Elgjo K, Stave R. Quantitative distribution of immunoglobulinproducing cells in gastric mucosa: relation to chronic gastritis and glandular atrophy. Gut. 1986; 27:505–14.

    Article  PubMed  CAS  Google Scholar 

  15. Valnes K, Brandtzaeg P. Subclass distribution of mucosal IgG-producing cells in gastritis. Gut. 1989;30:322–6.

    Article  PubMed  CAS  Google Scholar 

  16. Mai UI, Perez-Perez GI, Allen JB, Wahl SM, Blaser MJ, Smith PD. Surface proteins from Helicobacter pylori exhibit chemostatic activity for human leukocytes and are present in gastric mucosa. J Exp Med. 1992;175:517–25.

    Article  PubMed  CAS  Google Scholar 

  17. Tytgat GNT. Does the stomach adapt to Helicobacter pylori? Scand J Gastroenterol. 1992;27(Supp1.193):28–32.

    Article  Google Scholar 

  18. Isaacson P. Immunoperoxidase study of the secretory immunoglobulin system and lysozyme in normal and diseased gastric mucosa. Gut. 1982;23:578–88.

    Article  PubMed  CAS  Google Scholar 

  19. Crabtree JE, Taylor JD, Wyatt JI et al. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration and gastric pathology. Lancet. 1991;338:332–5.

    Article  PubMed  CAS  Google Scholar 

  20. Newell DG, Stacey AR. Isotype and specificity of local and systemic anti-Helicobacter pylori antibodies. In: Menge H, Gregor M, Tytgat GNJ, Marshall BJ, McNulty CAM, editors. Helicobacter pylori 1990. Berlin: Springer-Verlag; 1991:83–9.

    Google Scholar 

  21. Wirth HP, Vogt P, Ammann R, Altorfer J. IgA antikorper gegan Helicobacter pylori in magensekret; gastrische sekretorische immunantwork oder specihelverunreinigung? Schweiz Med Wochschr. 1993;123:1106–10.

    CAS  Google Scholar 

  22. Crabtree JE, Shallcross TM, Wyatt JI et al. Mucosal humoral immune response to Helicobacter pylori in patients with duodenitis. Dig Dis Sci. 1991;44:768–71.

    CAS  Google Scholar 

  23. Newell DG. Human antibody responses to the surface protein antigens of Campylobacter pyloridis. Serodiagn Immunother. 1987;1:209–17.

    Article  Google Scholar 

  24. Hu LT, Mobley HLT. Purification and N-terminal analysis of urease from Helicobacter pylori. Infect Immun 1990;58:992–8.

    PubMed  CAS  Google Scholar 

  25. Hawtin PR, Stacey AR, Newell DG. Investigation of the structure and localization of the urease of Helicobacter pylori using monoclonal antibodies. J Gen Microbiol. 1990;136:1995–2000.

    Article  PubMed  CAS  Google Scholar 

  26. Perez-Perez GI, Olivares AZ, Cover TL, Blaser MJ. Characteristics of Helicobacter pylori variants selected for urease deficiency. Infect Immun. 1992;60:3658–63.

    PubMed  CAS  Google Scholar 

  27. Evans DJ, Evans DG, Engstrand L, Graham DY. Urease-associated heat shock protein of Helicobacter pylori. Infect Immun. 1992;60:2125–7.

    PubMed  CAS  Google Scholar 

  28. Dunn BE, Roop RM, Sung C-C, Sharma SA, Perez-Perez GI, Blaser MJ. Identification and purification of a cpn60 heat shock protein homolog from Helicobacter pylori. Infect Immun. 1992;60:1046–1051.

    Google Scholar 

  29. Macchia G, Massone A, Burroni D, Covacci A, Censini S, Rappuoli R. The Hsp60 protein of Helicobacter pylori: structure and immune response in patients with gastroduodenal diseases. Mol Microbiol. 1993;9:645–52.

    Article  PubMed  CAS  Google Scholar 

  30. Von Wulffen H, Grote HJ. Enzyme-linked immunosorbent assay for detection of immunoglobulin A and G antibodies to Campylobacter pylori. Eur J Clin Microbiol Infect Dis. 1988;7:559–65.

    Article  Google Scholar 

  31. Apel I, Jacobs E, Kist M, Bredt W. Antibody response of patients against a 120 kDa surface protein of Campylobacter pylori. Zentralbi Bakteriol Microbiol Hyp. 1988; 268:271–6.

    CAS  Google Scholar 

  32. Crabtree JE, Figura N, Taylor JD, Bugnoli M, Armellini D, Tompkins DS. Expression of 120 kilodalton protein and cytotoxicity in Helicobacter pylori. J Clin Pathol. 1992;45:733–4.

    Article  PubMed  CAS  Google Scholar 

  33. Jones DM, Eldridge J, Fox AJ, Sethi P, Whorwell PJ. Antibody to the gastric Campylobacterlike organism (’Campylobacter pyloridis’) - clinical correlations and distribution in the normal population. J Med Microbiol. 1986;22:57–62.

    Article  PubMed  CAS  Google Scholar 

  34. Von Wulffen H, Grote Hi, Gaterman S, Loning T, Berger B, Buhl C Immunoblot analysis of immune response to Campylobacter pylori and its clinical associations. J Clin Pathol. 1988;41:653–9.

    Article  Google Scholar 

  35. Geis G, Suerbaum S, Forsthoff B, Leying H, Opferkuch W. Ultrastructure and biochemical studies of the flagellar sheath of Helicobacter pylori. J Med Microbiol. 1993;38:371–7.

    Article  PubMed  CAS  Google Scholar 

  36. Suerbaum S, Josenhans C, Labigne A. Cloning and genetic characterisation of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of mutants by electroporation-mediated allelic exchange. J Bacteriol. 1993;175:3278–88.

    PubMed  CAS  Google Scholar 

  37. Newell DG, Nuijten PJM, Stacey AR, Hazell SL. The cloning and partial sequence analysis of the catalse gene of Helicobacter pylori. In: Gasbarrini G, Pretolani S, editors. Basic and clinical aspects of Helicobacter pylori infection. Berlin: Springer-Verlag; 1993:223–6.

    Google Scholar 

  38. Wyatt JI, Rathbone BJ, Heatley RV. Local immune response to gastric Campylobacter in non-ulcer dyspepsia. J Clin Microbiol. 1986;39:86370.

    Google Scholar 

  39. Langenberg W, Rauws EAJ, Widjojokusumo A, Tytgat GNJ, Zanen HC. Identification of Campylobacter pyloridis isolates by restriction endonuclease DNA analysis. J Clin Microbiol. 1986;24:414–17.

    PubMed  CAS  Google Scholar 

  40. Langenberg W, Rauws EAJ, Oudbier JH, Tytgat GNJ. Patient-to-patient transmission of Campylobacter pylori infection by fiber optic gastroduodenoscopy and biopsy. J Infect Dis. 1990;167:507–11.

    Article  Google Scholar 

  41. Das SS, Karin QN, Easmon CSF. Opsonophagocytosis of Campylobacter pylori. J Med Microbiol. 198;27:125–30.

    Google Scholar 

  42. Pruul H, Lee PC, Goodwin CS, McDonald PJ, Interaction of Campylobacter pyloridis with human immune defence mechanisms. J Med Microbiol. 1987;23:233–8.

    Article  PubMed  CAS  Google Scholar 

  43. Pruul H, Lee PC, Goodwin CS, McDonald PJ, Interaction of Campylobacter pyloridis with human immune defence mechanisms. J Med Microbiol. 1987;23:233–8.

    Article  PubMed  CAS  Google Scholar 

  44. Neilsen N, Andersen LP. Chemotactic activity of Helicobacter pylori sonicate for human polymorphonuclear leucocytes and monocytes. Gut. 1992;33:738–42.

    Article  Google Scholar 

  45. Steer HW. Ultrastructure of Helicobacter pylori in vivo. In: Rathbone Bi, Heatley RV, editors. Helicobacter pylori and gastroduodenal disease, 2nd edn. Oxford: Blackwell Scientific Publications; 1992:42–50.

    Google Scholar 

  46. McKinlay AW, Young A, Russell RI, Gemmell CG. Opsonic requirements of Helicobacter pylori. J Med Microbiol. 1993;38:209–15.

    Article  PubMed  CAS  Google Scholar 

  47. Evans DJ, Evans DG, Smith KE, Graham DY. Serum antibody responses to the Nacetylneuraminyllactose-binding hemagglutinin of Campylobacter pylori. Infect Immun 1989;57:664–7.

    PubMed  CAS  Google Scholar 

  48. Stacey AR, Hawtin PR, Newell DG. Antigenicity of fractions of Helicobacter pylori prepared by fast protein liquid chromatography and urease captured by monoclonal antibodies. Eur J Clin Microbiol Infect Dis. 1990;9:732–7.

    Article  PubMed  CAS  Google Scholar 

  49. Hawtin PR, Stacey AR, Newell DG. Investigation of the structure and localization of the urease of Helicobacter pylori using monoclonal antibodies. J Gen Microbiol. 1990;136:1995–2000.

    Article  PubMed  CAS  Google Scholar 

  50. Cover TL, Cao P, Murthy UK, Sipple MS, Blaser MJ. Serum neutralizing antibody response to the vacuolating cytotoxin of Helicobacter pylori. J Clin Invest. 1992;90:913–18.

    Article  PubMed  CAS  Google Scholar 

  51. Chen M, Lee A, Hazell S Immunisation against gastric helicobacter infection in a mouse/Helicobacter fells model. Lancet. 1992;339:1120–1.

    Article  PubMed  CAS  Google Scholar 

  52. Czinn SJ, Cai A, Negrud JG. Protection of germ-free mice from infection by Helicobacter fells after active oral or passive IgA immunization. Vaccine. 1993;11:637–42.

    Article  PubMed  CAS  Google Scholar 

  53. Newell DG, Stacey AR. Isotype and specificity of local and systemic anti-Helicobacter pylori antibodies. In: Menge H, Gregor M, Tytgat GNJ, Marchall BJ, McNulty CAM, editors. Helicobacter pylori 1990. Berlin: Springer-Verlag; 1991:83–8.

    Google Scholar 

  54. Rautelin H, Kosunen TU. Helicobacter pylori and associated gastroduodenal diseases. APMIS. 1991;99:677–95.

    Article  PubMed  CAS  Google Scholar 

  55. Blaser MJ. Hypotheses on the pathogenesis and natural history of Helicobacter pylori-induced inflammation. Gastroenterology. 1992;102:720–7.

    PubMed  CAS  Google Scholar 

  56. Aalberse RC, Van der Gaag R, Leeuwen J. Serologic aspects of IgG4 antibodies. 1. Prolonged immunization results in an IgG4 restricted response. J Immunol. 1993;130:722–6.

    Google Scholar 

  57. Negrini R, Lisato L, Cavazzini L et al. Monoclonal antibodies for specific immunoperoxidase detection of Campylobacter pylori. Gastroenterology. 1989;96:414–20.

    PubMed  CAS  Google Scholar 

  58. Rathbone BJ, Trejdosiewicz LK. A strain-restricted monoclonal antibody to Campylobacter pyloridis. In Kaijser B, Falsen E, editors. Campylobacter IV. Goteborg: University of Goteborg; 1988:426–7.

    Google Scholar 

  59. Palley LS, Murphy J, Yan L, Taylor N, Polidoro D, Fox J. The effects of an oral immunisation scheme using muramyl dipeptide as an adjuvant to prevent gastric Helicobacter mustelae infection of ferrets. Acta Gastroenterol Belg. 1993;56(Suppl.):54.

    Google Scholar 

  60. Eaton KA, Krakowka S. Chronic gastritis due to Helicobacter pylori in immunized gnotobiotic piglets. Gastroenterology. 1992;103:1580–6.

    PubMed  CAS  Google Scholar 

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Authors
  1. D. G. Newell
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  2. A. R. Stacey
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Editor information

Editors and Affiliations

  1. Division of Gastroenterology, McMaster University Medical Centre, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada

    Richard H. Hunt (Professor of Medicine, Director) (Professor of Medicine, Director)

  2. Department of Gastroenterology and Hepatology, Academic Medical Centre, 9 Meibergdreef, 1105 AZ, Amsterdam, The Netherlands

    Guido N. J. Tytgat (Professor) (Professor)

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© 1994 Springer Science+Business Media Dordrecht

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Newell, D.G., Stacey, A.R. (1994). B cell responses in H. pylori infection. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1418-9_28

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  • DOI: https://doi.org/10.1007/978-94-011-1418-9_28

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-4620-6

  • Online ISBN: 978-94-011-1418-9

  • eBook Packages: Springer Book Archive

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