Abstract
Helicobacter pylori causes duodenal ulcers (DU), and various lines of research are examining the roles of bacterial and host factors in this effect. We and others have examined whether the abnormalities of gastroduodenal physiology that were previously described in DU disease are actually due to H. pylori infection.
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References
Soll AH. Duodenal ulcer and drug therapy. In: Sleisenger MH, Fordtran JS, editors. Gastrointestinal disease, 4th edn. Philadelphia: Saunders; 1989: 814–79.
Blair AJ, Feldman M, Barnett C, Walsh JH, Richardson CT. Detailed comparison of basal and food-stimulated gastric acid secretion rates and serum gastrin concentrations in duodenal ulcer patients and normal subjects. J Clin Invest. 1987; 79: 582–7.
Walsh JH, Richardson CT, Fordtran JS. pH dependence of acid secretion and gastrin release in normal and ulcer subjects. J Clin Invest. 1975; 55: 462–8.
Malagelada JR, Longstreth GF, Deering TB, Summerskill WHJ, Go VLW. Gastric secretion and emptying after ordinary meals in duodenal ulcer. Gastroenterology. 1977; 73: 989–96.
Sjovall M, Lindstedt G, Olbe L, Lundell L. Defective inhibition of gastrin release by antral distension in duodenal ulcer patients. Digestion. 1992; 51: 1–9.
Kihl B, Olbe L. Inhibition of pentagastrin-stimulated gastric acid secretion by graded intraduodenal administration of oleic acid in man. Scand J Gastroenterol. 1981; 16: 121–8.
Taylor IL, Dockray GJ, Calam J, Walker RJ. Big and little gastrin responses to food in normal and ulcer subjects. Gut. 1979; 20: 957–62.
McHenry L, Vuyyuru L, Schubert ML. Helicobacter pylori and duodenal ulcer disease; the somatostatin link? (Selected summaries). Gastroenterology. 1993; 104: 1573–5.
Eysselein VE, Maxwell V, Reedy T, Wunsch E, Walsh JH. Similar potencies of synthetic big and little gastrins in man. J Clin Invest. 1984; 73: 1284–90.
Calam J, Dockray GJ, Walker RJ, Tracey HJ, Owens D. Molecular forms of gastrin in peptic ulcer: a comparison of serum and tissue concentrations of G17 and G34 in gastric and duodenal ulcer subjects. Eur J Clin Invest. 1980; 10: 241–7.
Levi S, Beardshall K, Playford R, Ghosh P, Haddad G, Calam J. Campylobacter pylori and duodenal ulcers: the gastrin link. Lancet. 1989; 1: 1167–8.
Moss SF, Calam J. Helicobacter pylori and peptic ulcers: the present position. Gut. 1992; 33: 289–92.
Beardshall K, Moss S, Gill J, Levi S, Ghosh P, Playford RJ, Calam J. Suppression of Helicobacter pylori reduces gastrin releasing peptide stimulated gastrin release in duodenal ulcer patients. Gut. 1992; 33: 601–3.
Graham DY, Opekun A, Lew GM, Klein PD, Walsh JH. Helicobacter pylori-associated exaggerated gastrin release in duodenal ulcer patients. The effect of bombesin infusion and urea ingestion. Gastroenterology. 1991; 100 (6): 1571–5.
Mulholland G, Ardill JES, Fillmore D, Chittajallu RS, Fullarton GM, McKoll KEL. Helicobacter pylori related hypergastrinaemia is the result of a selective increase in gastrin 17. Gut. 1993; 34: 757–61.
Kovaks TOG, Sytnik B, Calam J, Walsh JH. Helicobacter pylori infection impairs pH inhibition in non-duodenal ulcer subjects. Gastroenterology. 1993; 104: A123.
Yamada T, Chiba T. Somatostatin. In: Makhlouf GM, editor. Handbook of physiology–the gastrointestinal system, Section 6, vol 2. Bethesda: American Physiological Society; 1989: 431–53.
Karnick PS, Monahan SJ, Wolfe MM. Inhibition of gastrin gene expression by somatostatin. J Clin Invest. 1989; 83: 367–72.
Park J, Chiba T, Yamada T. Mechanism for direct inhibition of canine gastric pareital cells by somastostatin. J Biol Chem. 1987; 262: 14190.
Holst JJ, Jensen SL, Knuhtsen S, Nielsen OV, Rehfeld JF. Effect of vagus, gastric inhibitory peptide and HCl on gastrin and somatostatin release from perfused pig antrum. Am J Physiol. 1983; 244: G515.
Brand SJ, Stone D. Reciprocal regulation of antral gastrin and somatostatin gene expression by omeprazole-induced achlorhydria. J Clin Invest. 1988; 82: 1059–66.
Wu V, Sumii K, Tari A, Sumii M, Walsh JH. Regulation of rat antral gastrin and somatostatin gene expression during starvation and after refeeding. Gastroenterology. 1991; 101: 1552–8.
Chiba T, Taminato T, Kadawaki S et al. Effects of glucagon, secretin and vasoactive intestinal polypeptide on gastric somatostatin and gastrin release from isolated perfused rat stomach. Gastroenterology. 1980; 79: 67–71.
Dockray GJ, Hamer C, Evans C, Varro A, Dimaline R. The secretory kinetics of the G-cell in omeprazole-treated rats. Gastroenterology. 1991; 100: 1187–94.
Moss SF, Legon S, Bishop AE, Polak JM, Calam J. Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease. Lancet. 1992; 340: 930–3.
Kekki M, Sipponen P, Siurala M. Progression of antral and body gastritis in active and healed duodenal ulcer and duodenitis. Scand J Gastroenterol. 1984; 19: 382–8.
Moss SF, Legon S, Calam J. Reciprocal changes in antral gastrin and somatostatin in pernicious anaemia. Dig Dis Sci. 1993 (in press).
Kaneko H, Nakada K, Mitsuma T et al. H. pylori infection induces a decrease in immunoreactive-somatostatin concentrations of the human stomach. Dig Dis Sci. 1992; 37: 409–16.
Graham DY, Alpert LC, Lacey-Smith J, Yoshimura HH. Iatrogenic Campylobacter infection is a cause of epidemic achlorhydria. Am J Gastroenterol. 1988; 83: 971–80.
Cave DR, Vargas M. Effect of a Campylobacter pylori protein on acid secretion by parietal cells. Lancet. 1989; 2: 187–9.
Hunt RH. Campylobacter pylori and spontaneous hypochlorhydria. In: Rathbone BJ, Heatley RV, editors. Campylobacter pylori and gastroduodenal disease. London: Blackwell Scientific; 1989: 175–84.
Saperas-ES, Yang-H, Rivier C, Tache Y. Central action of recombinant interleukin-1 to inhibit acid secretion in rats. Gastroenterology. 1990; 99: 1599–606.
Fong TL, Dooley CP, Dehesa M et al. Helicobacter pylori infection in pernicious anaemia: a prospective controlled study. Gastroenterology. 1991; 100: 328–32.
El-Omar E, Penman I, Dorrian CA, Ardill JES, McColl KEL. Eradicating Helicobacter pylori infection lowers gastrin-mediated acid secretion by two-thirds in duodenal ulcer patients. Gut. 1993; 34: 1060–5.
Schubert ML, Jong MJ, Maklouf GM. Bombesin/GRP-stimulated somatostatin secretion is mediated by gastrin in the antrum and intrinsic neurons in the fundus. Am J Physiol. 1991; 261: G885–90.
Moss SF, Calam J. Acid secretion and sensitivity to gastrin in duodenal ulcer patients: effect of eradication of H. pylori. Gut. 1993; 34: 888–92.
Khasawneh-SM, Affarah-HB. Morning versus evening dose: a comparison of three H2-receptor blockers in duodenal ulcer healing. Am J Gastroenterol. 1992; 87: 1180–2.
Achord JL. Gastric pepsin and acid secretion in patients with acute and healed duodenal ulcer. Gastroenterology. 1981; 81: 15–20.
Beardshall K, Adamson D, Gill J, Unwin R, Calam J. Helicobacter pylori raises the pH of the juxta epithelial region of the mucus layer of the gastric antrum and body. Gut. 1991; 32: A569.
Kelly SM, Crampton J, Hunter JO.Helicobater pylori increases the pH of the gastric mucosa in vivo. Gut. 1990;31:A1177–78(abstract).
Odera G, Kuvidi M, Garbo G et al. Antral and fundic surface mucosal pH in children with and without Helicobacter pylori. Gut. 1993; 34: S36.
Chittajallu RS, Neitherdutt WD, Macdonald AMI, McColl KEL. Effect of increasing Helicobacter pylori ammonia production by urea infusion on plasma gastrin concentrations. Gut. 1991; 32: 21–4.
Dunn BE, Campbell GP, Perez Perez GI, Blaser MJ. Purification and characterization of urease from Helicobacter pylori. J Biol Chem. 1990; 256 (16): 9464–9.
El Nujumi AM, Dorian CA, Chitajallu RS, Neithercut WD, McColl KEL. Effect of inhibition of H. pylori urease activity by acetohydroxamic acid on serum gastrin in duodenal ulcer subjects. Gut. 1991; 32: 866–70.
Chittajallu RS, Dorrian CA, Neithercut WD, Dahill S, McColl KEL. Is Helicobacter pylori-associated hypergastrinaemia due to the bacterium’s urease activity or the antral gastritis? Gut. 1991; 32: 1286–90.
Fahrenkrug J, Schaffalitzky de Muckadell OB, Hornum I, Rehfeld JF. The mechanism of hypergastrinemia in achlorhydria. Effect of food, acid, and calcitonin on serum gastrin concentrations and component pattern in pernicious anemia, with correlation to endogenous secretin concentrations in plasma. Gastroenterology. 1976; 71 (1): 33–7.
Blaser MJ. Hypothesis on the pathogenesis and natural history of Helicobacter pylori-induced inflammation. Gastroenterology. 1992; 102: 720–7.
Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI. Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut. 1991; 32: 1473–7.
Gupta R, Moss S, Thomas DM, Abbott F, Rees A, Calam J. Helicobacter pylori increases release of interleukin-8: a potent attractant of neutrophils. Gut. 1991; 32: A1206.
Crabtree JE, Peichl P, Wyatt JI, Lindley U. Gastric interleukin-8 and anti-interleukin-8 IgA antibodies in Helicobacter pylori infection. Ir J Med Sci. 1992; 161 (Suppl. 10): 20.
Atherton JC, Hudson N, Hale TL, Kirk GE, Spiller RC, Hawkey CJ. Interleukin-1B in gastric biopsy samples: relationship with inflammation and epithelial hyperplasia. Ir J Med Sci. 1992; 161 (Suppl. 10): 57.
Nouch LA, Bosma NB, Jansen JE. Mucosal interleukin-1B and interleukin-8 production in patients with Helicobacter pylori infection. Ir J Med Sci. 1992; 161 (Suppl. 10): 57.
Fan XJ, Chua CN, Shahi CN et al. Tumour necrosis factor-alpha and gamma-interferon production by patients with Helicobacter pylori. Ir J Med Sci. 1992; 161 (Suppl.10): 58.
Denizot Y, Sobbani J, Rambaud JC, Lewin M, Thomas Y, Beneveniste J. Paf acether synthesis by Helicobacter pylori. Gut. 1990; 31: 1242–5.
Teichmann RK, Grab PJ, Hammer C, Brendel W. Gastrin release by interleukin-2 and gamma-interferon in vitro. Can J Phys Pharm. 1986; 64 (Suppl.): 62.
Teichmann RK, Kramling HJ, Merle Y, Merkle R. Opposite effects of interleukin-1 on gastrin and bombesin release in cell suspensions of antral mucosa. Digestion. 1990; 46 (Suppl.1): 114.
Teichmann RK, Utz E, Becker HD. Leukotrienes release gastrin and somatostatin from human antral mucosa in vitro. Digestion. 1990; 46 (Suppl.1): 114.
Weigert N, Stolley S, Schusdziarra V, Calssen M, Schepp W. Interleukin-1B but not leukotriene-B4 stimulates gastrin release from rat antral G-cells in primary culture. Ir J Med Sci. 1992; 161 (Suppl.10): 55.
Golodner EH, Territo MC, Walsh JH, Soll AH. Stimulation of gastrin release from cultured canine G cells by Helicobacter pylori and mononuclear cells. Gastroenterology. 1992; 102: A630.
Golodner EH, Soll AH, Walsh JH, Calam J. Release of gastrin from cultured canine G-cells by interferon-gamma and tumour necrosis factor-alpha. Gastroenterology. 1993; 104: A89.
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Calam, J., Moss, S., Toker, N., Legon, S. (1994). H. pylori, gastrin and somatostatin. In: Hunt, R.H., Tytgat, G.N.J. (eds) Helicobacter pylori. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-1418-9_22
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DOI: https://doi.org/10.1007/978-94-011-1418-9_22
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