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Herpes simplex virus vectors

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Molecular and Cell Biology of Human Gene Therapeutics

Part of the book series: Molecular and Cell Biology of Human Diseases Series ((Mol. Cell Biol. Hu. Dis.,volume 20))

Abstract

Advances in the methodology and practice of human gene therapy have been substantial in the past few years. In contrast to traditional palliative forms of therapy in which a therapeutic drug, protein or peptide product must be repeatedly administered to treat a disease, successful gene therapy would result in endogenous production of the therapeutic product in situ. Research on the design and application of gene transfer vehicles and genetically altered cells to the treatment of a variety of diseases has greatly expanded the dimension and scope of this field such that almost any genetic alteration of cells and tissues to effect a therapeutic outcome is now considered to employ the principles of gene therapy. Moreover, developments primarily in the use of novel viral vectors coupled with the rapid discovery of new disease-causing genes have driven the field with increasing vigor.

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Authors
  1. Joseph Glorioso
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  2. Mary Ann Bender
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  3. David Fink
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  4. Neal Deluca
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Editors and Affiliations

  1. Department of Biochemistry, Royal Holloway, University of London, Egham, Surrey, TW20 0EX, UK

    George Dickson

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Glorioso, J., Bender, M.A., Fink, D., Deluca, N. (1995). Herpes simplex virus vectors. In: Dickson, G. (eds) Molecular and Cell Biology of Human Gene Therapeutics. Molecular and Cell Biology of Human Diseases Series, vol 20. Springer, Dordrecht. https://doi.org/10.1007/978-94-011-0547-7_3

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  • DOI: https://doi.org/10.1007/978-94-011-0547-7_3

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