Abstract
As tissue engineering comes to the forefront as a cutting-edge discipline, one of the principle challenges is the need for new materials that are fully bioresorbable and biocompatible. To this extent, pseudo-poly(amino acid)s such as tyrosine-derived polycarbonates present themselves as a promising new class of degradable polymers. These materials offer a high degree of bone biocompatibility. Variations in pendent chain structure allow the generation of a series of materials with variations in key mechanical and cellular response properties. In addition, their chemical structure provides convenient attachment points for the covalent linkage of bioactive molecules to the polymer backbone. Tyrosine-derived polycarbonates can be shaped by commonly used processing and fabrication methods — another advantage over conventional poly(amino acid)s which are often non-processible .
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Abramson, S.D., Seyda, A., Sit, P.S., Kohn, J. (2002). Characterization of Degradable Polymers for Orthopedic Application. In: Reis, R.L., Cohn, D. (eds) Polymer Based Systems on Tissue Engineering, Replacement and Regeneration. NATO Science Series, vol 86. Springer, Dordrecht. https://doi.org/10.1007/978-94-010-0305-6_9
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DOI: https://doi.org/10.1007/978-94-010-0305-6_9
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