Skip to main content

Con A Induced Suppressor Cell Activity in IBD and Other Inflammatory Diseases

  • Chapter
Recent Advances in Crohn’s Disease

Part of the book series: Developments in Gastroenterology ((DIGA,volume 1))

Abstract

During the past several years the regulation of the immune response, particularly regarding suppressor cell activity, has met with considerable interest, and a number of different suppressor cell systems, some specific, others nonspecific, have been described (Reviewed in 1,2). For the study of suppressor cell function in man, two test systems were mainly used: the measure of T cell controlled in vitro proliferation, differentiation, and immunoglobulin production of human B lymphocytes following polyclonal activation with pokeweed mitogen [PWM] and the investigation of the ability of in vitro concanavalin A [Con A] — activated lymphocytes to suppress proliferation responses of autologous or allogeneic responder cells (3,4).

Supported by Fonds zur Forderung der wissenschaftlichen Forschung in Österreich

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

References

  1. Gershon RK. (1974) T cell control of antibody production. Contemp.Top.Immunobiol. 3:1

    PubMed  CAS  Google Scholar 

  2. Waldmann TA, Broder S. (1977) Suppressor cells in the regulation of the immune response. Prog.Clin.Immunol. 3:155–199

    PubMed  CAS  Google Scholar 

  3. Waldmann TA, Broder S, Blaese RM, Durm M, Blackman M, Strober W. (1974) Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia. Lancet 2:609–613

    Article  PubMed  CAS  Google Scholar 

  4. Shou L, Schwartz SA, Good RA. (1976) Suppressor cell activity after concanavalin A treatment of lymphocytes from normal donors. J.Exp.Med. 143:1100–1110

    Article  PubMed  CAS  Google Scholar 

  5. Steinbrocker O, Traeger CH, Battermann RC. (1949) Therapeutic criteria in rheumatoid arthritis (1. Classification of progression of rheumatoid arthritis.) JAMA 140:659–662

    CAS  Google Scholar 

  6. Knapp W, Posch B. (1980) Concanavalin A-induced suppressor cell activity: opposing effects of hydrocortisone. J.Immunol. 124:168–172

    PubMed  CAS  Google Scholar 

  7. Sakane T, Steinberg AD, Green I. (1978) Studies of immune functions of patients with systemic lupus erythematosus. I. Dysfunction of suppressor T-cell activity related to impaired generation of, rather than response to, suppressor cells. Arthritis Rheum. 21:657–664

    Article  PubMed  CAS  Google Scholar 

  8. Hodgson HJF, Wands JR, Isselbacher KJ. (1978) Decreased suppressor cell activity in inflammatory bowel disease. Clin.Exp.Imm. 32:451–458

    CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1981 Martinus Nijhoff Publishers bv, The Hague

About this chapter

Cite this chapter

Knapp, W. et al. (1981). Con A Induced Suppressor Cell Activity in IBD and Other Inflammatory Diseases. In: Peña, A.S., Weterman, I.T., Booth, C.C., Strober, W. (eds) Recent Advances in Crohn’s Disease. Developments in Gastroenterology, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8273-4_84

Download citation

  • DOI: https://doi.org/10.1007/978-94-009-8273-4_84

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-8275-8

  • Online ISBN: 978-94-009-8273-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics