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Some aspects of the transport of glucose and ketone bodies into the brain and retina

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Transport and Inherited Disease

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Abstract

This chapter, based on work in vivo, is restricted essentially to transport at the blood-tissue interface. The kinetic characteristics of transport at the blood-brain and blood-retinal interfaces will determine the quantities of the metabolites (in this case glucose or ketone bodies) which become available to the cells of the tissue and will therefore play an important role in the regulation of metabolism. Indeed, experimental evidence suggests that, at least for the brain, metabolism can be restricted by the activity of the transport process. This particularly applies to the ketone bodies1,2 and also under certain circumstances e.g. hypoglycae-mia, to glucose3–5.

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  1. E. R. Love
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Editors and Affiliations

  1. Department of Child Life and Health, University of Edinburgh, 17, Hatton Place, Edinburgh, UK

    N. R. Belton

  2. Department of Chemical Pathology, Old Medical School, Thoresby Place, Leeds, UK

    C. Toothill

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Love, E.R. (1981). Some aspects of the transport of glucose and ketone bodies into the brain and retina. In: Belton, N.R., Toothill, C. (eds) Transport and Inherited Disease. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-7316-9_6

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  • DOI: https://doi.org/10.1007/978-94-009-7316-9_6

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