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The Maturation of Megakaryocytes and their Precursors

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Blood cells in nuclear medicine, part I

Part of the book series: Developments in Nuclear Medicine ((DNUM,volume 6))

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Abstract

Maturation and amplification of the thrombocytic cells is achieved by a sequence of cells which are termed megakaryocyte progenitors, promegakaryoblasts and megakaryoblasts and finally promegakaryocytes and megakaryocytes. Amplification in these cells follows distinct mechanisms. Cellular multiplication occurs only at the progenitor stage. In promegakaryoblasts and megakaryoblasts a second amplification process does not yield any increase in cell number but rather consists of a series of endoduplications resulting in a polyploid cell whose nuclear and cytoplasmic volume are roughly proportional to ploidy level. Finally arrest of DNA synthesis and endoduplications marks the transition to the megakaryocyte stage. The present paper will briefly review the physiology of these cells.

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Authors
  1. J. M. Paulus
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Editors and Affiliations

  1. Department of Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Max R. Hardeman PhD

  2. Department of Nuclear Medicine, Hôpital Saint Louis, Paris, France

    Yves Najean MD

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© 1984 Martinus Nijhoff Publishers, The Hague

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Paulus, J.M. (1984). The Maturation of Megakaryocytes and their Precursors. In: Hardeman, M.R., Najean, Y. (eds) Blood cells in nuclear medicine, part I. Developments in Nuclear Medicine, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-6027-5_5

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  • DOI: https://doi.org/10.1007/978-94-009-6027-5_5

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-009-6029-9

  • Online ISBN: 978-94-009-6027-5

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