Abstract
Among the spectrum of diverse secondary metabolites produced by fungi are a group of compounds called tremorgens; so named because of their ability to cause tremors or similar nervous signs when administered to or ingested by animals. There is also a chemical relationship among most of the tremorgens, in that many possess an indole moiety [6]. The chemical classification of Cole [6] includes six groups of fungal tremorgens; the paspalitrem group, the penitrem group, the fumitremorgin-verruculogen group, the tryptoquivaline group, the janthitrem group, and the territrem group. The emphasis of this presentation will be on the penitrems of the penitrem group of tremorgens, the fungi that produce penitrems, and their effects on animals and animal systems.
No endorsements are herein implied.
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References
Arp, L.H. & Richard, J.L. 1979. Intoxication of dogs with the mycotoxin penitrem A. J. Am. Vet. Med. Assoc. 175:565–566.
Arp, L.H. & Richard, J.L. 1981. Experimental intoxication of guinea pigs with multiple doses of the mycotoxin, penitrem A. Mycopathologia 73:109–113.
Catovic, S., Filipovic, N. & Stern, P. 1975. The effect of penitrem A upon the level of glycine in the CNS. Bull. Scientifique 20:284–285.
Ciegler, A. 1969. Tremorgenic toxin from Penicillium palitans. Appl. Microbiol. 18:128–129.
Ciegler, A. & Pitt, J.I. 1970. Survey of the genus Penicillium for tremorgenic toxin production. Mycopathol. Mycol. Appl. 42:119–124.
Cole, R.J. 1981. Fungal tremorgens. J. Food Protect. 44:715–722.
Curtis, D. R., Duggan, A. W. & Johnston, G. A. R. 1971. The specificity of strychnine as a glycine antagonist in the mammalian spinal cord. Exp. Brain Res. 12:547–565.
Cysewski, S.J., Baetz, A.L. & Pier, A.C. 1975. Penitrem A intoxication of calves: Blood chemical and pathologic changes. Am. J. Vet. Res. 36:53–58.
Day, J.B. & Mantle, P.G. 1980. Tremorgenic forage and rye grass staggers. Vet. Rec. 106:463–464.
de Jesus, A.E., Steyn, P.S., Van Heerden, F.R., Vleggaar, R. & Wessels, P.L. 1981. Structure and biosynthesis of the penitrems A-F, Six novel tremorgenic mycotoxins from Penicilliumcrustosum. J. Chem. Soc. Chem. Comm. 6:289–291.
de Jesus, A.E., Steyn, P.S., Van Heerden, F.R., Vleggaar, R. & Wessels, P.L. 1983. Tremorgenic mycotoxins from Penicillium crustosum: Isolation of penitrems A-F and the structure elucidation and absolute configuration of penitrem A. J. Chem. Soc. Perkin Trans. 1:1847–1856.
DiMenna, M.E., Mantle, P.G. & Mortimer, P.H. 1976. Experimental production of a staggers syndrome in ruminants by a tremorgenic Penicillium from soil. N. Z. Vet. J. 24:45–46.
Dorner, J.W., Cole, R.J. & Hill, R.A. 1984.-Tremorgenic mycotoxins produced by Aspergillus fumigatus and Penicilliumcrustosum isolated from molded corn implicated in a natural intoxication of cattle. J. Agric. Food Chem. 32:411–413.
Hayes, A. W., Presley, D.B. & Neville, J. A. 1976. Acute toxicity of penitrem A in dogs. Toxicol. Appl. Pharmacol. 35:311–320.
Hayes, A.W., Phillips, R.D. & Wallace, L.C. 1977. Effect of penitrem A on mouse liver composition. Toxicon 15:293–300.
Hou, C.T., Ciegler, A. & Hesseltine, C.W. 1970. Tremorgenic toxins from penicillia I. Colorimetric determination of tremortins A and B. Anal. Biochem. 37:422–428.
Hou, C.T., Ciegler, A. & Hesseltine, C.W. 1971. Tremorgenic toxins from penicillia II. A new tremorgenic toxin, tremortin B, from Penicilliumpalitans. Can. J. Microbiol. 17:599–603.
Malaiyandi, M., Vesonder, R.F. & Ciegler, A. 1976. Large scale production, purification and a study of some spectral properties of penitrem A.J. Environ. Sci. Health B 11:139–164.
Mantle, P.G., Day, J.B., Haigh, C.R. & Penny, R.H.C. 1978. Tremorgenic mycotoxins and inco-ordination syndromes. Vet Rec. 103:403.
Mantle, P.G. & Penny, R.H.C. 1981. Tremorgenic mycotoxins and neurological disorders — A review. In: The Veterinary Annual, Grunsell, G.S., Hill, G. & F.W.G. (eds.). John Wright and Sons, Ltd., Bristol, England, p. 51–62.
Mantle, P.G., Laws, I., Tan, M.J.L. & Tizand, M. 1984. A novel process for the production of penitrem mycotoxins by submerged fermentation of Pénicilliumnigricans. J. Gen. Microbiol. 130:1293–1298.
Patterson, D.S.P., Roberts, B.A., Shreeve, B.J., MacDonald, S.M. & Hayes, A.W. 1979. Tremorgenic toxins produced by soil fungi. Appl. Environ. Microbiol. 37:172–173.
Penny, R.H.C., O’Sullivan, B.M., Mantle, P.G. & Shaw, B.I. 1979. Clinical studies on tremorgenic mycotoxicoses in sheep. Vet. Rec. 105:392–393.
Peterson, D.W., Penny, R.H.C., Day, J.B. & Mantle, P.G. 1982. A comparative study of sheep and pigs given the tremorgenic mycotoxins verruculogen and penitrem A. Res. Vet. Sci. 33:183–187.
Pitt, J.I. 1979. Penicilliumcrustosum and P. simplicissimum, the correct names for two common species producing tremorgenic mycotoxins. Mycologia. 71:1166–1176.
Pitt, J.I. 1979. The Genus Penicillium and Its Teleomorphic States Eupenicillium and Talaromyces, Academic Press, New York.
Ramirez, C. 1982. Manual and Atlas of the Penicillia, Elsevier Biomedical Press, New York.
Raper, K.B. & Thom, C. 1968. A Manual of the Penicillia, Hafner Publishing Co., Inc., New York.
Richard, J.L. & Arp, L.H. 1979. Natural occurrence of the mycotoxin penitrem A in moldy cream cheese. Mycopathologia 67:107–109.
Richard, J.L., Bacchetti, P. & Arp, L.H. 1981. Moldy walnut toxicosis in a dog, caused by the mycotoxin, penitrem A. Mycopathologia 76:55–58.
Shreeve, B.J., Patterson, D.S.P., Roberts, B.A. & MacDonald, S.M. 1979. The occurrence of soil-borne tremorgenic fungi in England and Wales. Vet. Ree. 104:509.
Stern, P. 1971. Pharmacological analysis of the tremor induced by cyclopium toxin. Jugoslav Physiol. Pharmacol. Acta 7:187–196.
Stern, P. & Catovic, S. 1974. Mechanism of mephenesine action. Naunyn Schmiedebergs Arch. Pharmacol. 285:76R.
Toussoun, T.A. & Nelson, P.E. 1976. A pictorial guide to the identification of Fusarium species. Second edit. The Pennsylvania State Univ. Press, University Park, PA.
Ueno, Y. & Ueno, I. 1978. Toxicology and biochemistry of mycotoxins. In: Toxicology Biochemistry and Pathology of Mycotoxins, Uraguchi, K. & M. Yamazaki, M. (eds.). John Wiley & Sons, New York, p. 107–188.
Wagener, R.E., David, N.D. & Diener, U.L. 1980. Penitrem A and roquefortini production by Penicillium commune. Appl. Environ. Microbiol. 39:882–887.
Wells, J.M. & Cole, R.J. 1977. Production of penitrem A and of an unidentified toxin by Penicillium lanoso-coeraleum isolated from weevil-damaged pecans. Phytopath 67:779–782.
Wilson, B.J., Wilson, C.A. & Hayes, A.W. 1968. Tremorgenic toxin from Penicilliumcyclopium grown on food materials. Nature 220:77–78.
Wyatt, R.D., Hamilton, P.B., Colwell, W.M. & Ciegler, A. 1972. The effect of tremortin A on chickens. Avian Dis. 16:461–464.
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© 1986 Martinus Nijhoff Publishers, Dordrecht
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Richard, J.L., Peden, W.M., Thurston, J.R. (1986). Occurrence of penitrem mycotoxins and clinical manifestations of penitrem intoxications. In: Richard, J.L., Thurston, J.R. (eds) Diagnosis of Mycotoxicoses. Current Topics in Veterinary Medicine and Animal Science, vol 33. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4235-6_5
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DOI: https://doi.org/10.1007/978-94-009-4235-6_5
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