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Acceleration of Metastatic Growth after Surgical Excision of the Primary Tumor in the Experimental Animals

  • Chapter
Metastasis / Dissemination

Part of the book series: Cancer Growth and Progression ((CAGP,volume 8))

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Abstract

Metastatic cells originate in the primary tumor and spread widely into a variety of tissues and organs. Entering of tumor cells into the bloodstream is just the initial step in the metastatic cascade and does not necessarily result in metastatic growth. The presence of tumor cells in the circulation did not correlate with the probability of developing distant metastases in cancer patients (48). In order to establish metastatic tumors, cells also have to extravasate, survive in the new environment and proliferate there. The metastatic potency of tumor cells vary over a substantial range. In some cancer patients, highly metastatic tumor cells can develop distant metastases from very small or just histologically detectable primary tumors. Conversely, some patients bearing a huge tumor mass for years can be free from disseminated tumor nodules (58).

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Authors
  1. Elizier Gorelik
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Editors and Affiliations

  1. Pittsburgh Cancer Institute, Pittsburgh, Pa, USA

    Elizier L. Gorelik

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© 1989 Kluwer Academic Publishers, Dordrecht

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Gorelik, E. (1989). Acceleration of Metastatic Growth after Surgical Excision of the Primary Tumor in the Experimental Animals. In: Gorelik, E.L. (eds) Metastasis / Dissemination. Cancer Growth and Progression, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-2534-2_10

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  • DOI: https://doi.org/10.1007/978-94-009-2534-2_10

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-7645-6

  • Online ISBN: 978-94-009-2534-2

  • eBook Packages: Springer Book Archive

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