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The Evolution of Diversity within Tumors and Metastases

  • Chapter
Fundamental Aspects of Cancer

Part of the book series: Cancer Growth and Progression ((CAGP,volume 1))

Abstract

Despite advances in the use of aggressive adjuvant chemotherapy and radiotherapy, which in combination with surgery are often successful in the eradication of the primary tumor, most deaths in cancer patients result from metastasis. This chapter reviews the process of metastasis on a cellular basis and is approached using as a goal the improvement of therapeutic protocols. Excellent reviews on the mechanism of metastasis and the characteristics of metastatic cells are provided by L.A. Liotta elsewhere in this series.

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  1. James E. Talmadge
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  1. Pittsburgh Cancer Institute, 3343 Forbes Avenue, Pittsburgh, Pennsylvania, 15213, USA

    Ronald H. Goldfarb Ph.D.

  2. Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, USA

    Ronald H. Goldfarb Ph.D.

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Talmadge, J.E. (1989). The Evolution of Diversity within Tumors and Metastases. In: Goldfarb, R.H. (eds) Fundamental Aspects of Cancer. Cancer Growth and Progression, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-1089-8_8

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