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Fundamental Aspects of Cancer

  • Book
  • © 1989

Overview

Editors:
  1. Ronald H. Goldfarb

    1. Pittsburgh Cancer Institute, Pittsburgh, USA
      Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, USA

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Part of the book series: Cancer Growth and Progression (CAGP, volume 1)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-x
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  2. The Biology of Human Cancer, and the Development of a Rational Basis for Treatment

    • Arthur S. Levine
    Pages 1-22

  3. Organ Culture: Use in Experimental Oncology for Comparisons Among Species

    • David G. Kaufman, Gene P. Siegal
    Pages 23-27

  4. Overview of Current Understanding of Tumor Spread

    • Ronald H. Goldfarb, Kenneth W. Brunson
    Pages 28-32

  5. Intraspecies and Interspecies Comparison

    • H. E. Kaiser
    Pages 33-34

  6. The Life Span of Mammals: A Comparison

    • H. E. Kaiser, J. Paradiso, M. Jones
    Pages 35-40

  7. The Culmination of Neoplastic Development in the Mammal

    • H. E. Kaiser
    Pages 41-42

  8. The Influence of the Body Structure on Tumor Development

    • H. E. Kaiser
    Pages 43-46

  9. The Evolution of Diversity within Tumors and Metastases

    • James E. Talmadge
    Pages 47-64

  10. Neoplastic Heterogeneity and Clinical Chemotherapy

    • Stephen K. Carter
    Pages 65-72

  11. The Attraction of Wandering Metastatic Cells

    • James Varani, J. Philip McCoy, Peter A. Ward
    Pages 73-83

  12. Tumor-Cell Interactions with Blood Vessels during Cancer Metastasis

    • Peter A. Netland, Bruce R. Zetter
    Pages 84-97

  13. Comparative Importance of the Lymphatic System during Neoplastic Progression: Lymphohematogenous Spreading

    • H. E. Kaiser
    Pages 98-133

  14. Immunological Control of Tumor Metastases

    • E. L. Gorelik, R. B. Herberman
    Pages 134-143

  15. Role of Macrophages in Recognition and Destruction of Metastatic Cells

    • Rajiv Nayar, Isaiah J. Fidler
    Pages 144-155

  16. Metastases from Metastasis: Clinical Relevance in Human Cancer

    • John D. Crissman
    Pages 156-161

  17. Treatment Research in Cancer

    • Gregory A. Curt, Bruce A. Chabner
    Pages 162-170

  18. Chemotherapy from Animals to Man

    • Takao Ohnuma, James F. Holland
    Pages 171-191

  19. Therapy of Metastasis in Animal Models

    • Vincent A. Pollack
    Pages 192-200

  20. Back Matter

    Pages 201-211
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Keywords

About this book

Individual neoplastic diseases often show discrete growth direct effect of tumor metastases or to adverse consequences patterns subject to many modifications according to the associated with these therapeutic modes (e.g., complications stage of the disease, the species involved and the tumor type of immunosuppression which can lead to mortality arising concerned. Primary neoplasms are less difficult to treat in from infectious disease). contrast to secondary neoplasms. The chief type of secon­ It is therefore quite clear that there is a crucial need for dary neoplastic growth, metastasis, is also comparatively new methods for the detection of micrometastases and the development of new modalities for the treatment of estab­ less well understood. Phylogenetically, metastasis attains its highest level of development in the mammal and is best lished metastases. It is likely that such modalities must known in man, but is still far from being understood. overcome tumor heterogeneity and drug resistance to yield new therapeutic modalities with improved margin of safety The process of cancer growth and progression, from the initiation of neoplastic transformation of normal cells to the and efficacy over currently available anti-neoplastic drugs.

Editors and Affiliations

  • Pittsburgh Cancer Institute, Pittsburgh, USA

    Ronald H. Goldfarb

  • Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, USA

    Ronald H. Goldfarb

Bibliographic Information

  • Book Title: Fundamental Aspects of Cancer

  • Editors: Ronald H. Goldfarb

  • Series Title: Cancer Growth and Progression

  • DOI: https://doi.org/10.1007/978-94-009-1089-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Springer Book Archive

  • Copyright Information: Kluwer Academic Publishers 1989

  • Softcover ISBN: 978-94-010-6980-9Published: 26 September 2011

  • eBook ISBN: 978-94-009-1089-8Published: 06 December 2012

  • Series ISSN: 1871-3238

  • Edition Number: 1

  • Number of Pages: 214

  • Topics: Oncology, Pathology, Veterinary Medicine/Veterinary Science

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