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Metal Complexes as Photochemical Probes of DNA Structure

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Photochemical Probes in Biochemistry

Part of the book series: NATO ASI Series ((ASIC,volume 272))

Abstract

Transition metal chemistry provides a versatile means to develop reagents which with photoactivation cleave DNA either in a sequence-specific or sequence-uniform fashion. In my laboratory we have exploited the photochemistry of tris(phenanthroline) metal complexes and their derivatives in developing such photocleaving molecules.1 The tris(phenanthroline) complexes are illustrated schematically below.

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References

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Author information

Authors and Affiliations

  1. Department of Chemistry, Columbia University, New York, New York, 10027, USA

    Jacqueline K. Barton

Authors
  1. Jacqueline K. Barton
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Editor information

Editors and Affiliations

  1. Department of Biochemistry B, University of Copenhagen The Panum Institute, Blegdamsvej 3c, 2200, Copenhagen, Denmark

    Peter E. Nielsen

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© 1989 Kluwer Academic Publishers

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Barton, J.K. (1989). Metal Complexes as Photochemical Probes of DNA Structure. In: Nielsen, P.E. (eds) Photochemical Probes in Biochemistry. NATO ASI Series, vol 272. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-0925-0_14

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  • DOI: https://doi.org/10.1007/978-94-009-0925-0_14

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-010-6905-2

  • Online ISBN: 978-94-009-0925-0

  • eBook Packages: Springer Book Archive

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