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Role of Cancer Stem Cell in Mammary Carcinogenesis and Its Clinical Implication

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Stem Cells and Cancer Stem Cells, Volume 10

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 10))

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Abstract

Accumulating evidence shows the presence of a subpopulation of cancer stem cells in many cancers including breast cancer. The breast cancer stem cells are resistant to treatments and able to initiate tumorigenesis, these features suggest that they may contribute to therapy resistance and relapse and thus making them a promising target for improving outcome of treatments. The expression of specific markers in breast cancer stem cells and development of mouse model has facilitated the study and several intrinsic and extrinsic pathways maintaining breast cancer stem cell population have been exploited. The discovery of different states of breast cancer stem cells provides more insights in how cancer stem cells are maintained and regulated. Compounds targeting pathways maintaining cancer stem cells are under development and several have already entered clinical trials. Breast cancer stem cell studies deliver a potential and effective regimen for improving outcomes of breast cancer patients.

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Authors and Affiliations

  1. Comprehensive Cancer Center, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA

    Yajing Liu

  2. School of Life Sciences, University of Science and Technology of China, 443 Huangshan Rd, Hefei, Anhui, 230027, China

    Suling Liu

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  1. Yajing Liu
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  2. Suling Liu
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Correspondence to Suling Liu .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Liu, Y., Liu, S. (2013). Role of Cancer Stem Cell in Mammary Carcinogenesis and Its Clinical Implication. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 10. Stem Cells and Cancer Stem Cells, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6262-6_17

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