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The Importance of CYP2E1 in the Pathogenesis of Alcoholic Liver Disease and Drug Toxicity and the Role of the Proteasome

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Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism

Part of the book series: Subcellular Biochemistry ((SCBI,volume 67))

Abstract

The chapter discusses about the critical role of CYP2E1 in ethanol mediated liver injury and its association with NASH. Ethanol metabolism by CYP2E1 generates hydroxyethyl radicals which promote ethanol hepatotoxicity. Greater induction of CYP2E1 and hence greater liver injury occurs with co-administration of ethanol and drugs. Induction of CYP2E1 leads to prominent epigenetic effects and CYP2E1 polymorphism may be associated with alcoholic liver disease. These are some aspects of CYP2E1, amongst many others which account for its importance in the context of drug metabolism and disease development and have been reviewed in the chapter.

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Acknowledgement

The author thanks Adriana Flores for typing the manuscript and Barbara French for editing it.

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  1. Department of Pathology, Harbor-UCLA Medical Center, 1000 W. Carson St., Torrance, CA, 90502, USA

    Samuel W. French

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  1. Samuel W. French
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Correspondence to Samuel W. French .

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  1. , AU-KBC Research Centre, Anna University, MIT Campus, Chromepet, Chennai, 600044, India

    Aparajita Dey

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French, S.W. (2013). The Importance of CYP2E1 in the Pathogenesis of Alcoholic Liver Disease and Drug Toxicity and the Role of the Proteasome. In: Dey, A. (eds) Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism. Subcellular Biochemistry, vol 67. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5881-0_4

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