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Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism

  • Aparajita¬†Dey

Part of the Subcellular Biochemistry book series (SCBI, volume 67)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Arthur I. Cederbaum
    Pages 105-130
  3. Helmut K. Seitz, Xiang-Dong Wang
    Pages 131-143
  4. M. Raj Lakshman, Mamatha Garige, Maokai A. Gong, Leslie Leckey, Ravi Varatharajalu, Robert S. Redman et al.
    Pages 199-233
  5. Claire Heit, Hongbin Dong, Ying Chen, David C. Thompson, Richard A. Deitrich, Vasilis K. Vasiliou
    Pages 235-247
  6. Back Matter
    Pages 249-256

About this book

Introduction

The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1), which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities, which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of the central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.

Keywords

Cytochrome P4502E1 diseases drugs injury reactive oxygen species

Editors and affiliations

  • Aparajita¬†Dey
    • 1
  1. 1., AU-KBC Research CentreAnna UniversityChennaiIndia

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-5881-0
  • Copyright Information Springer Science+Business Media Dordrecht 2013
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-5880-3
  • Online ISBN 978-94-007-5881-0
  • Series Print ISSN 0306-0225
  • Buy this book on publisher's site