Cardiovascular Stem Cells

  • Christoph Brenner
  • Robert David
  • Wolfgang-Michael Franz
Chapter

Abstract

Ischemic disorders are the main cause of death in the Western world. With more patients surviving their acute myocardial infarction and an aging population, congestive heart failure is the rising health problem. At present, heart transplantation remains the only curative treatment for end stage heart failure. The discrepancy between demand and supply of donor organs does not fill the clinical need. This explains the huge effort made in the field of stem cell research trying to establish alternative resources for tissue replacement. In contrast to adult stem cells mainly acting in a paracrine fashion pluripotent stem cells have the potential to generate transplantable myocardial and vascular tissue.

Due to the low percentage of cardiovascular progenitor cells in pluripotent stem cell cultures, various approaches using exogenous factors aim for their amplification and purification in vitro. However, one future key technology may be genetic forward programming based on profound understanding of differentiation pathways in order to direct stem cell differentiation towards cardiovascular fates. In this regard, subtype specific programming has already been achieved by overexpression of distinct early cardiovascular transcription factors leading to populations of either predominantly early/intermediate type cardiomyocytes or differentiated ventricular myocardial cells, respectively.

In addition, techniques for gentle purification of myocardial and vascular progenitor cells will have to be further refined in order to enable the generation of highly specific, pure and safe cell populations for transplantations and for tissue engineering.

Keywords

Enhanced Green Fluorescent Protein Pluripotent Stem Cell Cardiovascular Development Heart Field Biological Pacemaker 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Christoph Brenner
    • 1
  • Robert David
    • 1
  • Wolfgang-Michael Franz
    • 1
  1. 1.Department of Internal Medicine IUniversity of Munich – Campus GrosshadernMunichGermany

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