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Multipotent Progenitor Cells in Regenerative Cardiovascular Medicine

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Abstract

Regenerative therapies for heart diseases require the understanding of the molecular mechanisms that govern the fates and differentiation of the diverse muscle and nonmuscle cell lineages that form during heart development. During mouse cardiogenesis, the major lineages of the mature heart, cardiomyocytes, smooth muscle, endothelial cells, and cardiac mesenchyme, arise from multipotent cardiovascular progenitors expressing the transcription factors Mesp1, Isl1, Nkx2-5, and Tbx18. Recent identification of stem/progenitor cells of embryonic origin with intrinsic competence to differentiate into multiple lineages of the heart offers exciting new possibilities for cardiac regeneration. When combined with new advances in nuclear reprogramming, the prospect of achieving autologous, cardiomyogenic, stem-cell-based therapy might be within reach.

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Acknowledgments

The authors would like to thank members of the laboratory for their helpful discussions and comments. We apologize to those colleagues whose work is not mentioned here due to space limitations. The authors of this work are supported by a Marie Curie Excellence Team Grant from the European Research Council (MEXT-23208), the German Research Foundation (La 1238 3-1/4-1), and the Ministry for Research and Education (01 GN 0826).

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  1. Klinikum rechts der Isar and German Heart Center, Technical University of Munich, I. Medical Clinic, Molecular Cardiology, Ismaninger Strasse 22, 81675, Munich, Germany

    Jason T. Lam, Alessandra Moretti & Karl-Ludwig Laugwitz

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  1. Jason T. Lam
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Correspondence to Jason T. Lam.

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Lam, J.T., Moretti, A. & Laugwitz, KL. Multipotent Progenitor Cells in Regenerative Cardiovascular Medicine. Pediatr Cardiol 30, 690–698 (2009). https://doi.org/10.1007/s00246-009-9450-1

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