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Allele Re-sequencing Technologies

  • Stephen Byrne
  • Jacqueline D. Farrell
  • Torben Asp
Chapter

Abstract

The development of next-generation sequencing technologies has made sequencing an affordable approach for detection of genetic variations associated with various traits. However, the cost of whole genome re-sequencing still remains too high to be feasible for many plant species with large and complex genomes. Recent developments in strategies for target-enrichment, transcriptome re-sequencing, and partial genome re-sequencing allows for enrichment for regions of interest at a scale that is matched to the throughput of next-generation sequencing platforms, and has emerged as a promising alternative to whole genome re-sequencing to identify causative genetic variations in plants. One challenge, however, will be efficient bioinformatics strategies for data handling and analysis from the increasing amount of sequence information.

Keywords

Cloud Computing Sequencing Platform Selector Probe Roche NimbleGen Single Molecule Sequencing 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Stephen Byrne
    • 1
  • Jacqueline D. Farrell
    • 1
  • Torben Asp
    • 1
  1. 1.Department of Molecular Biology and Genetics, Faculty of Science and Technology, Research Centre FlakkebjergAarhus UniversitySlagelseDenmark

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