Abstract
Pineal parenchymal tumors (PPTs) are rare intracranial neoplasmatic growths in pineal region, affecting both children and adults. The current WHO classification of PPTs include: pineocytoma, pineoblastoma, pineal parenchymal tumor of intermediate differentiation (PPTID), and papillary tumor of pineal region (PTPR). However, the biology and prognosis of these tumors remains to be better understood. Immunohistochemistry is used to look at tissue-specific antigens, like neuronal and glial markers, as well as proliferation or apoptosis markers, specific pineal markers and others. This technique may greatly contribute to recognize PPTs biology and prognosis in individual cases. Identification of reliable diagnostic markers and prognostic factors for pineal region tumors is the key challenge for investigations in this field. In this section, the review of immunohistochemical studies on those tumors is presented.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Arivazhagan A, Anandh B, Santosh V, Chandramouli BA (2008) Pineal parenchymal tumors – utility of immunohistochemical markers in prognostication. Clin Neuropathol 27:325–333
Cuello AC (1993) Immunohistochemistry II, vol 14, IBRO handbook series: methods in the neurosciences. Wiley, Chichester, 474 p
Fèvre-Montange M, Szathmari A, Champier J, Mokhtari K, Chrétien F, Coulon A, Figarella-Branger D, Polivka M, Varlet P, Uro-Coste E, Fouchon F, Jouvet A (2008a) Pineocytoma and pineal parenchymal tumors of intermediate differentiation presenting cytologic pleomorphism: a multicenter study. Brain Pathol 18:354–359
Fèvre-Montange M, Champier J, Szathmari A, Brisson C, Reboul A, Mottolese C, Fouchon F, Claustrat B, Jouvet A (2008b) Histological features and expression of enzymes implicated in melatonin synthesis in pineal parenchymal tumours and in cultured tumoural pineal cells. Neuropathol Appl Neurobiol 34:296–305
Fukuda T, Akiyama N, Ikegami M, Takahashi H, Sasaki A, Oka H, Komori T, Tanaka Y, Nakazato Y, Akimoto J, Tanaka M, Okada Y, Saito S (2010) Expression of hydroxyindole-O-methyltransferase enzyme in the human central nervous system and in pineal parenchymal cell tumors. J Neuropathol Exp Neurol 69:498–510
Hasselblatt M, Blümcke I, Jeibmann A, Rickert CH, Jouvet A, van de Nes JA, Kuchelmeister K, Brunn A, Fèvre-Montange M, Paulus W (2006) Immunohistochemical profile and chromosomal imbalances in papillary tumours of the pineal region. Neuropathol Appl Neurobiol 32:278–283
Hirato J, Nakazato Y (2001) Pathology of pineal region tumors. J Neurooncol 54:239–249
Ikota H, Kinjo S, Yokoo H, Nakazato Y (2006) Systematic immunohistochemical profiling of 378 brain tumors with 37 antibodies using tissue microarray technology. Acta Neuropathol 111:475–482
Javois LC (1995) Immunocytochemical methods and protocols, vol 34, Methods in molecular biology. Humana Press, Totowa, 456 p
Jouvet A, Fèvre-Montange M, Besançon R, Derrington E, Saint-Pierre G, Belin MF, Pialat J, Lapras C (1994) Structural and ultrastructural characteristics of human pineal gland, and pineal parenchymal tumors. Acta Neuropathol 88:334–348
Kumar P, Tatke M, Sharma A, Singh D (2006) Histological analysis of lesions of the pineal region: a retrospective study of 12 years. Pathol Res Pract 202:85–92
Marcol W, Kotulska K, Larysz-Brysz M, Malinowska-Kołodziej I, Mandera M, Lewin-Kowalik J (2006) Expression of Bcl-2 and Bax protein in normal pineal gland in children and young adult. J Mol Histol 37:5–7
Marcol W, Mandera M, Grajkowska W, Malinowska-Kołodziej I, Olakowska E, Właszczuk A, Lewin-Kowalik J (2009) Apoptotic proteins and markers of differentiation in childhood pineal parenchymal tumors: relationships and prognostic value. Cen Eur Neurosurg 70:115–124
Nakazato Y (2008) Revised WHO classification of brain tumours. Brain Nerve 60:59–77
Sato K, Kubota T (2009) Pathology of pineal parenchymal tumors. Prog Neurol Surg 23:12–25
Schild SE, Scheithauer BW, Schomberg PJ, Hook CC, Kelly PJ, Frick L, Robinow JS, Buskirk SJ (1993) Pineal parenchymal tumors. Clinical, pathologic, and therapeutic aspects. Cancer 72:870–880
Sugawara K, Kurihara H, Negishi M, Saito N, Nakazato Y, Sasaki T, Takeuchi T (2002) Nestin as a marker for proliferative endothelium in gliomas. Lab Invest 82:345–351
Tsumanuma I, Sato M, Okazaki H, Tanaka R, Washiyama K, Kawasaki T, Kumanishi T (1995) The analysis of p53 tumor suppressor gene in pineal parenchymal tumors. Noshuyo Byori 12:39–43
Tsumanuma I, Tanaka R, Washiyama K (1999) Clinicopathological study of pineal parenchymal tumors: correlation between histopathological features, proliferative potential, and prognosis. Brain Tumor Pathol 16:61–68
Yamane Y, Mena H, Nakazato Y (2002) Immunohisto-chemical characterization of pineal parenchymal tumors using novel monoclonal antibodies to the pineal body. Neuropathology 22:66–76
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Marcol, W. et al. (2013). Pineal Parenchymal Tumors: Immunohistochemistry. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 10. Tumors of the Central Nervous System, vol 10. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-5681-6_4
Download citation
DOI: https://doi.org/10.1007/978-94-007-5681-6_4
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-5680-9
Online ISBN: 978-94-007-5681-6
eBook Packages: MedicineMedicine (R0)